Longitudinal associations of cumulative average GL (each 20 unit) with yearly weight regain and changes in markers of glycemic status during WLM. Analyses were performed with use of a linear mixed model with repeated measurements. Model 1 was adjusted for age, sex, ethnicity, weight- or glycemic status–related outcomes at the start of WLM (8 weeks), BMI at 8 weeks, and time as fixed effects and intervention center and participant identifier as random effects. Model 2 was additionally adjusted for time-varying accelerometry-measured PA and time-varying self-reported energy intake (kcal ⋅ day−1) and dietary components including intake of fat, protein, fiber, and alcohol (all in E%). Model 3 was additionally adjusted for time-varying yearly changes in BW. *Yearly mean change and 95% CI of main effects indicating the amount of increase in anthropometric outcomes or body composition or markers of glycemic status increased per year by 20-unit increment in GL. †P values for main effects.