A: Relationship between AR difference (ΔIR in Table 1) and base risk rate (= IRPlb in Table 1) for several clinically relevant outcomes in five recent CVOTs (listed in Table 1). The darker-shaded area includes the 95% CI of the fit and the lighter-shaded area the 95% CI of individual points. The arrows connect data from the same trial in which the analysis of major adverse CV events (MACE) was reported separately for patients with established atherosclerotic CVD (higher risk) or multiple CV risk factors (lower risk). B: Relationship between RR difference (HR in Table 1) and base risk rate (= IRPlb in Table 1) for several clinically relevant outcomes in five recent CVOTs (listed in Table 1). HHF, hospitalization for heart failure; ΔIR, change in absolute incident event rate.