eGFRcr-cys trajectories in T1D patients with NA and progressive renal decline (loss ≥3.3% per year) during 4–10 years of follow-up. The trajectories are plotted in patients with baseline eGFRcr-cyst ≥105 mL/min (A) and in patients with baseline eGFRcr-cys <105 mL/min (B). Lines in red indicate presence of macroalbuminuria. E, ESRD.