A: Rates of insulin independence after allogeneic islet infusion (islet transplant alone and IAK), annually after last infusion. Left: By era (P = 0.02). Right: By induction immunosuppression category (P < 0.01). B: Durability of graft function (basal C-peptide ≥0.3 ng/mL) after the last infusion, by era (P < 0.001; left). The immediate drop at time 0 is occurrences of primary nonfunction (i.e., C-peptide never ≥0.3 ng/mL). In the most recent era, 95% of those who ever achieved insulin independence (II) retained graft function through 3 years after last infusion compared with 70% for those who never achieved II (P < 0.001; right). C: Percentage of patients with HbA1c <6.5% or drop by two percentage points (P = 0.03; left); and absence of severe hypoglycemic events regardless of complete graft failure (P = NS by era; there were insufficient data from 2007–2010; right). D: The percentage with HbA1c <6.5% or drop by 2% increases with increasing C-peptide level (P < 0.001; left), as does absence of severe hypoglycemic events (P < 0.001; right), annually after the last infusion. (A high-quality color representation of this figure is available in the online issue.)