Time to T1D in patients’ relatives who were initially without diabetes and islet autoantibody–positive (Ab+), by DPT-1 Risk Score (≤7 vs. >7), number of positive autoantibodies (i.e., single vs. multiple autoantibody positivity), and T1D GRS (<0.250 vs. ≥0.250) (P < 0.0001). While the T1D GRS did not further increase the predictive ability in the group with DPT-1 Risk Score >7, which already had high risk of T1D, it was able to stratify risk in individuals with DPT-1 Risk Score <7, with either a single positive autoantibody or multiple positive autoantibodies. DPTRS, DPT-1 Risk Score.