Five-year glycemic response (change from baseline in HbA1c) and weight change (percentage change from baseline) with thiazolidinediones (TZD) and sulfonylureas (SU) by sex- and obesity-defined subgroup. Data are presented as means ± SE at each study visit from mixed-effects models. A reduction (improvement) in HbA1c is represented as a negative value. For AUC and treatment difference estimates, positive values favor SU and negative values favor TZD. For RECORD weight change data, see Supplementary Fig. 7. A: ADOPT trial: absolute glycemic response (mmol/mol). B: RECORD trial: absolute glycemic response (mmol/mol). C: ADOPT trial: weight change from baseline (%).