Adjusted HRs and 95% CIs for heart failure according to a 1-SD increment in the biomarker. Model 1 was adjusted for age, sex, randomized blood pressure–lowering intervention, and randomized glucose-control intervention. Model 2 was additionally adjusted for duration of diabetes, current smoking, history of myocardial infarction, history of hospitalization for heart failure, BMI, systolic blood pressure, heart rate, current or previous atrial fibrillation, pathological Q-wave on ECG, left ventricular hypertrophy on ECG, aspirin or other antiplatelet agent use, β-blocker use, calcium channel blocker use, diuretic use, ACE inhibitor or angiotensin II receptor blocker use, total cholesterol, HDL cholesterol, triglyceride, statin or other lipid-lowering agent, HbA1c, thiazolidinedione use, insulin use, urinary ACR, and eGFR. Model 3 was additionally adjusted for the other biomarkers.