Severe (A) and confirmed (B) hypoglycemia over time among patients treated with liraglutide or placebo. Severe hypoglycemia was defined according to American Diabetes Association criteria as hypoglycemia requiring the assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions (16). Confirmed hypoglycemia was defined as severe hypoglycemia or minor hypoglycemia (defined as plasma glucose <3.1 mmol/L [<56 mg/dL] with or without symptoms). The number of episodes was analyzed using a negative binomial regression model with a log link and the logarithm of the observation time (100 years) as offset.