Class . | Compound(s) . | Dosage strength/product (if applicable) . | Median AWP (min, max)† . | Median NADAC (min, max)† . | Maximum approved daily dose* . |
---|---|---|---|---|---|
Biguanides | • Metformin | 850 mg (IR) | $106 ($5, $189) | $2 | 2,550 mg |
1,000 mg (IR) | $87 ($3, $144) | $2 | 2,000 mg | ||
1,000 mg (ER) | $242 ($242, $7,214) | $32 ($32, $160) | 2,000 mg | ||
Sulfonylureas (2nd generation) | • Glimepiride | 4 mg | $74 ($71, $198) | $3 | 8 mg |
• Glipizide | 10 mg (IR) | $70 ($67, $91) | $6 | 40 mg | |
10 mg (XL/ER) | $48 ($46, $48) | $11 | 20 mg | ||
• Glyburide | 6 mg (micronized) | $52 ($48, $71) | $12 | 12 mg | |
5 mg | $79 ($63, $93) | $9 | 20 mg | ||
Thiazolidinedione | • Pioglitazone | 45 mg | $345 ($7, $349) | $4 | 45 mg |
α-Glucosidase inhibitors | • Acarbose | 100 mg | $106 ($104, $106) | $29 | 300 mg |
• Miglitol | 100 mg | $241 ($241, $346) | NA | 300 mg | |
Meglitinides | • Nateglinide | 120 mg | $155 | $27 | 360 mg |
• Repaglinide | 2 mg | $878 ($58, $897) | $31 | 16 mg | |
DPP-4 inhibitors | • Alogliptin | 25 mg | $234 | $154 | 25 mg |
• Saxagliptin | 5 mg | $565 | $452 | 5 mg | |
• Linagliptin | 5 mg | $606 | $485 | 5 mg | |
• Sitagliptin | 100 mg | $626 | $500 | 100 mg | |
SGLT2 inhibitors | • Ertugliflozin | 15 mg | $390 | $312 | 15 mg |
• Dapagliflozin | 10 mg | $659 | $527 | 10 mg | |
• Canagliflozin | 300 mg | $684 | $548 | 300 mg | |
• Empagliflozin | 25 mg | $685 | $547 | 25 mg | |
GLP-1 RAs | • Exenatide (extended release) | 2 mg powder for suspension or pen | $936 | $726 | 2 mg** |
• Exenatide | 10 μg pen | $961 | $770 | 20 μg | |
• Dulaglutide | 4.5 mg mL pen | $1,064 | $852 | 4.5 mg** | |
• Semaglutide | 1 mg pen | $1,070 | $858 | 2 mg** | |
14 mg (tablet) | $1,070 | $858 | 14 mg | ||
• Liraglutide | 1.8 mg pen | $1,278 | $1,022 | 1.8 mg | |
• Lixisenatide | 20 μg pen | $814 | NA | 20 μg | |
GLP-1/GIP dual agonist | • Tirzepatide | 15 mg pen | $1,169 | $935 | 15 mg** |
Bile acid sequestrant | • Colesevelam | 625 mg tabs | $711 ($674, $712) | $83 | 3.75 g |
3.75 g suspension | $674 ($673, $675) | $177 | 3.75 g | ||
Dopamine-2 agonist | • Bromocriptine | 0.8 mg | $1,118 | $899 | 4.8 mg |
Amylin mimetic | • Pramlintide | 120 μg pen | $2,783 | NA | 120 μg/injection†† |
Class . | Compound(s) . | Dosage strength/product (if applicable) . | Median AWP (min, max)† . | Median NADAC (min, max)† . | Maximum approved daily dose* . |
---|---|---|---|---|---|
Biguanides | • Metformin | 850 mg (IR) | $106 ($5, $189) | $2 | 2,550 mg |
1,000 mg (IR) | $87 ($3, $144) | $2 | 2,000 mg | ||
1,000 mg (ER) | $242 ($242, $7,214) | $32 ($32, $160) | 2,000 mg | ||
Sulfonylureas (2nd generation) | • Glimepiride | 4 mg | $74 ($71, $198) | $3 | 8 mg |
• Glipizide | 10 mg (IR) | $70 ($67, $91) | $6 | 40 mg | |
10 mg (XL/ER) | $48 ($46, $48) | $11 | 20 mg | ||
• Glyburide | 6 mg (micronized) | $52 ($48, $71) | $12 | 12 mg | |
5 mg | $79 ($63, $93) | $9 | 20 mg | ||
Thiazolidinedione | • Pioglitazone | 45 mg | $345 ($7, $349) | $4 | 45 mg |
α-Glucosidase inhibitors | • Acarbose | 100 mg | $106 ($104, $106) | $29 | 300 mg |
• Miglitol | 100 mg | $241 ($241, $346) | NA | 300 mg | |
Meglitinides | • Nateglinide | 120 mg | $155 | $27 | 360 mg |
• Repaglinide | 2 mg | $878 ($58, $897) | $31 | 16 mg | |
DPP-4 inhibitors | • Alogliptin | 25 mg | $234 | $154 | 25 mg |
• Saxagliptin | 5 mg | $565 | $452 | 5 mg | |
• Linagliptin | 5 mg | $606 | $485 | 5 mg | |
• Sitagliptin | 100 mg | $626 | $500 | 100 mg | |
SGLT2 inhibitors | • Ertugliflozin | 15 mg | $390 | $312 | 15 mg |
• Dapagliflozin | 10 mg | $659 | $527 | 10 mg | |
• Canagliflozin | 300 mg | $684 | $548 | 300 mg | |
• Empagliflozin | 25 mg | $685 | $547 | 25 mg | |
GLP-1 RAs | • Exenatide (extended release) | 2 mg powder for suspension or pen | $936 | $726 | 2 mg** |
• Exenatide | 10 μg pen | $961 | $770 | 20 μg | |
• Dulaglutide | 4.5 mg mL pen | $1,064 | $852 | 4.5 mg** | |
• Semaglutide | 1 mg pen | $1,070 | $858 | 2 mg** | |
14 mg (tablet) | $1,070 | $858 | 14 mg | ||
• Liraglutide | 1.8 mg pen | $1,278 | $1,022 | 1.8 mg | |
• Lixisenatide | 20 μg pen | $814 | NA | 20 μg | |
GLP-1/GIP dual agonist | • Tirzepatide | 15 mg pen | $1,169 | $935 | 15 mg** |
Bile acid sequestrant | • Colesevelam | 625 mg tabs | $711 ($674, $712) | $83 | 3.75 g |
3.75 g suspension | $674 ($673, $675) | $177 | 3.75 g | ||
Dopamine-2 agonist | • Bromocriptine | 0.8 mg | $1,118 | $899 | 4.8 mg |
Amylin mimetic | • Pramlintide | 120 μg pen | $2,783 | NA | 120 μg/injection†† |
AWP, average wholesale price; DPP-4, dipeptidyl peptidase 4; ER and XL, extended release; GIP, glucose-dependent insulinotropic polypeptide; GLP-1 RA, glucagon-like peptide 1 receptor agonist; IR, immediate release; max, maximum; min, minimum; NA, data not available; NADAC, National Average Drug Acquisition Cost; SGLT2, sodium-glucose cotransporter 2.
Calculated for 30-day supply (AWP [72] or NADAC [73] unit price × number of doses required to provide maximum approved daily dose × 30 days); median AWP or NADAC listed alone when only one product and/or price.
Utilized to calculate median AWP and NADAC (min, max); generic prices used, if available commercially.
Administered once weekly.
AWP and NADAC calculated based on 120 μg three times daily.