Class . | Compound(s) . | Dosage strength/product (if applicable) . | Median AWP (min, max)† . | Median NADAC (min, max)† . | Maximum approved daily dose* . |
---|---|---|---|---|---|
Biguanides | • Metformin | 850 mg (IR) | $108 ($5, $109) | $3 | 2,550 mg |
1,000 mg (IR) | $87 ($5, $88) | $2 | 2,000 mg | ||
1,000 mg (ER) | $242 ($242, $7,214) | $102 ($102, $430) | 2,000 mg | ||
Sulfonylureas (2nd generation) | • Glimepiride | 4 mg | $74 ($71, $198) | $3 | 8 mg |
• Glipizide | 10 mg (IR) | $68 ($67, $70) | $3 | 40 mg | |
10 mg (XL/ER) | $48 | $12 | 20 mg | ||
• Glyburide | 6 mg (micronized) | $52 ($48, $71) | $11 | 12 mg | |
5 mg | $82 ($63, $93) | $12 | 20 mg | ||
Thiazolidinediones | • Pioglitazone | 45 mg | $348 ($7, $349) | $5 | 45 mg |
• Rosiglitazone | 4 mg | N/A | $324 | 8 mg | |
α-Glucosidase inhibitors | • Acarbose | 100 mg | $106 ($104, $106) | $26 | 300 mg |
• Miglitol | 100 mg | $284 ($241, $346) | N/A | 300 mg | |
Meglitinides (glinides) | • Nateglinide | 120 mg | $155 | $28 | 360 mg |
• Repaglinide | 2 mg | $878 ($58, $897) | $34 | 16 mg | |
DPP-4 inhibitors | • Alogliptin | 25 mg | $234 | $166 | 25 mg |
• Saxagliptin | 5 mg | $549 | $438 | 5 mg | |
• Linagliptin | 5 mg | $583 | $466 | 5 mg | |
• Sitagliptin | 100 mg | $596 | $477 | 100 mg | |
SGLT2 inhibitors | • Ertugliflozin | 15 mg | $372 | $297 | 15 mg |
• Dapagliflozin | 10 mg | $639 | $511 | 10 mg | |
• Canagliflozin | 300 mg | $652 | $521 | 300 mg | |
• Empagliflozin | 25 mg | $658 | $526 | 25 mg | |
GLP-1 RAs | • Exenatide (extended release) | 2 mg powder for suspension or pen | $909 | $727 | 2 mg** |
• Exenatide | 10 µg pen | $933 | $746 | 20 µg | |
• Dulaglutide | 4.5 mg mL pen | $1,013 | $811 | 4.5 mg** | |
• Semaglutide | 1 mg pen | $1,022 | $822 | 1 mg** | |
14 mg (tablet) | $1,022 | $819 | 14 mg | ||
• Liraglutide | 1.8 mg pen | $1,220 | $975 | 1.8 mg | |
• Lixisenatide | 20 µg pen | $814 | N/A | 20 µg | |
Bile acid sequestrant | • Colesevelam | 625 mg tabs | $710 ($674, $712) | $75 | 3.75 g |
3.75 g suspension | $674 | $222 | 3.75 g | ||
Dopamine-2 agonist | • Bromocriptine | 0.8 mg | $1,036 | $833 | 4.8 mg |
Amylin mimetic | • Pramlintide | 120 µg pen | $2,702 | N/A | 120 µg/injection†† |
Class . | Compound(s) . | Dosage strength/product (if applicable) . | Median AWP (min, max)† . | Median NADAC (min, max)† . | Maximum approved daily dose* . |
---|---|---|---|---|---|
Biguanides | • Metformin | 850 mg (IR) | $108 ($5, $109) | $3 | 2,550 mg |
1,000 mg (IR) | $87 ($5, $88) | $2 | 2,000 mg | ||
1,000 mg (ER) | $242 ($242, $7,214) | $102 ($102, $430) | 2,000 mg | ||
Sulfonylureas (2nd generation) | • Glimepiride | 4 mg | $74 ($71, $198) | $3 | 8 mg |
• Glipizide | 10 mg (IR) | $68 ($67, $70) | $3 | 40 mg | |
10 mg (XL/ER) | $48 | $12 | 20 mg | ||
• Glyburide | 6 mg (micronized) | $52 ($48, $71) | $11 | 12 mg | |
5 mg | $82 ($63, $93) | $12 | 20 mg | ||
Thiazolidinediones | • Pioglitazone | 45 mg | $348 ($7, $349) | $5 | 45 mg |
• Rosiglitazone | 4 mg | N/A | $324 | 8 mg | |
α-Glucosidase inhibitors | • Acarbose | 100 mg | $106 ($104, $106) | $26 | 300 mg |
• Miglitol | 100 mg | $284 ($241, $346) | N/A | 300 mg | |
Meglitinides (glinides) | • Nateglinide | 120 mg | $155 | $28 | 360 mg |
• Repaglinide | 2 mg | $878 ($58, $897) | $34 | 16 mg | |
DPP-4 inhibitors | • Alogliptin | 25 mg | $234 | $166 | 25 mg |
• Saxagliptin | 5 mg | $549 | $438 | 5 mg | |
• Linagliptin | 5 mg | $583 | $466 | 5 mg | |
• Sitagliptin | 100 mg | $596 | $477 | 100 mg | |
SGLT2 inhibitors | • Ertugliflozin | 15 mg | $372 | $297 | 15 mg |
• Dapagliflozin | 10 mg | $639 | $511 | 10 mg | |
• Canagliflozin | 300 mg | $652 | $521 | 300 mg | |
• Empagliflozin | 25 mg | $658 | $526 | 25 mg | |
GLP-1 RAs | • Exenatide (extended release) | 2 mg powder for suspension or pen | $909 | $727 | 2 mg** |
• Exenatide | 10 µg pen | $933 | $746 | 20 µg | |
• Dulaglutide | 4.5 mg mL pen | $1,013 | $811 | 4.5 mg** | |
• Semaglutide | 1 mg pen | $1,022 | $822 | 1 mg** | |
14 mg (tablet) | $1,022 | $819 | 14 mg | ||
• Liraglutide | 1.8 mg pen | $1,220 | $975 | 1.8 mg | |
• Lixisenatide | 20 µg pen | $814 | N/A | 20 µg | |
Bile acid sequestrant | • Colesevelam | 625 mg tabs | $710 ($674, $712) | $75 | 3.75 g |
3.75 g suspension | $674 | $222 | 3.75 g | ||
Dopamine-2 agonist | • Bromocriptine | 0.8 mg | $1,036 | $833 | 4.8 mg |
Amylin mimetic | • Pramlintide | 120 µg pen | $2,702 | N/A | 120 µg/injection†† |
AWP, average wholesale price; DPP-4, dipeptidyl peptidase 4; ER and XL, extended release; GLP-1 RA, glucagon-like peptide 1 receptor agonist; IR, immediate release; max, maximum; min, minimum; N/A, data not available; NADAC, National Average Drug Acquisition Cost; SGLT2, sodium–glucose cotransporter 2.
Calculated for 30-day supply (AWP [70] or NADAC [71] unit price × number of doses required to provide maximum approved daily dose × 30 days); median AWP or NADAC listed alone when only one product and/or price.
Utilized to calculate median AWP and NADAC (min, max); generic prices used, if available commercially.
Administered once weekly.
AWP and NADAC calculated based on 120 μg three times daily.