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TABLE 1

Comparison of Select AID Systems in the United States (24,31–33)

AID SystemOnboardingAID StrategyAutomation AdaptivityAdjustable ParametersSystem Features
Insulet Omnipod 5 System,* automated mode Automation begins with first Pod; maximum delivery is more constrained with first Pod for safety
Estimates TDI based on the programmed total basal insulin 
TDI-based insulin automation
Adjustable glucose targets of 110–150 mg/dL in 10-mg/dL increments, personalized for different times of day 
TDI updated with every Pod change (approximately every 72 hours) ICR, ICF, glucose targets, duration of insulin action (DIA) Automated Mode: Limited: Static basal rate determined by system without any adjustments based on CGM values; activates when CGM values are missing (e.g., during sensor warm-up) and resumes full automated mode automatically once CGM values return.
Activity: Set for 1- to 24-hour duration, with glucose target of 150 mg/dL and reduced insulin delivery 
Medtronic MiniMed 670G/770G, auto mode 48-Hour warm-up period with insulin delivery in manual mode required before user can activate auto mode TDI-based insulin automation
Glucose target: 120 mg/dL; nonadjustable 
TDI updated every 6 days at midnight ICR, DIA Safe Basal: Static basal rate determined by system without any adjustments based on CGM values
Temp Target: Set for 2- to 12-hour duration with glucose target of 150 mg/dL 
t:slim X2 with Control-IQ Weight and TDI programmed into pump before activating automation; used at onboarding to initiate automation
Programmed TDI used primarily for 2-hour maximum delivery constraints (50% TDI in 2-hour period) built into system for safety purposes 
Adjusts pre-programmed basal rates
Target glucose range: 112.5– 160 mg/dL; nonadjustable
Auto-correction boluses: maximum 1/hour only if there is no user-initiated bolus in the past hour; 60% of calculated correction dose using a fixed target of 110 mg/dL 
Actual TDI tracked by algorithm and primarily used to scale basal adjustments ICR, ICF, basal rates Sleep Activity: Narrows target glucose range to 112.5–120 mg/dL with no automated correction boluses; can program a sleep schedule or start/stop manually
Exercise Activity: Changes glucose target to 140–160 mg/dL; manual start/stop—cannot program a duration of use 
Medtronic MiniMed 780G,* auto mode 48-hour warm-up period with insulin delivery in manual mode before user can activate auto mode TDI-based insulin automation
Glucose target: 100 or 120 mg/dL
Auto-correction boluses: maximum every 5 minutes 
TDI updated every 6 days at midnight ICR, DIA, glucose target Safe Basal: Static basal rate determined by system without any adjustments based on CGM values
Temp Target: Set for 2- to 12-hour duration with glucose target of 150 mg/dL 
AID SystemOnboardingAID StrategyAutomation AdaptivityAdjustable ParametersSystem Features
Insulet Omnipod 5 System,* automated mode Automation begins with first Pod; maximum delivery is more constrained with first Pod for safety
Estimates TDI based on the programmed total basal insulin 
TDI-based insulin automation
Adjustable glucose targets of 110–150 mg/dL in 10-mg/dL increments, personalized for different times of day 
TDI updated with every Pod change (approximately every 72 hours) ICR, ICF, glucose targets, duration of insulin action (DIA) Automated Mode: Limited: Static basal rate determined by system without any adjustments based on CGM values; activates when CGM values are missing (e.g., during sensor warm-up) and resumes full automated mode automatically once CGM values return.
Activity: Set for 1- to 24-hour duration, with glucose target of 150 mg/dL and reduced insulin delivery 
Medtronic MiniMed 670G/770G, auto mode 48-Hour warm-up period with insulin delivery in manual mode required before user can activate auto mode TDI-based insulin automation
Glucose target: 120 mg/dL; nonadjustable 
TDI updated every 6 days at midnight ICR, DIA Safe Basal: Static basal rate determined by system without any adjustments based on CGM values
Temp Target: Set for 2- to 12-hour duration with glucose target of 150 mg/dL 
t:slim X2 with Control-IQ Weight and TDI programmed into pump before activating automation; used at onboarding to initiate automation
Programmed TDI used primarily for 2-hour maximum delivery constraints (50% TDI in 2-hour period) built into system for safety purposes 
Adjusts pre-programmed basal rates
Target glucose range: 112.5– 160 mg/dL; nonadjustable
Auto-correction boluses: maximum 1/hour only if there is no user-initiated bolus in the past hour; 60% of calculated correction dose using a fixed target of 110 mg/dL 
Actual TDI tracked by algorithm and primarily used to scale basal adjustments ICR, ICF, basal rates Sleep Activity: Narrows target glucose range to 112.5–120 mg/dL with no automated correction boluses; can program a sleep schedule or start/stop manually
Exercise Activity: Changes glucose target to 140–160 mg/dL; manual start/stop—cannot program a duration of use 
Medtronic MiniMed 780G,* auto mode 48-hour warm-up period with insulin delivery in manual mode before user can activate auto mode TDI-based insulin automation
Glucose target: 100 or 120 mg/dL
Auto-correction boluses: maximum every 5 minutes 
TDI updated every 6 days at midnight ICR, DIA, glucose target Safe Basal: Static basal rate determined by system without any adjustments based on CGM values
Temp Target: Set for 2- to 12-hour duration with glucose target of 150 mg/dL 
*

This system was not commercially available in the United States but was undergoing FDA review at the time of writing.

Both systems used the same AID algorithm.

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