Comparison of Select AID Systems in the United States (24,31–33)
| AID System . | Onboarding . | AID Strategy . | Automation Adaptivity . | Adjustable Parameters . | System Features . |
|---|---|---|---|---|---|
| Insulet Omnipod 5 System,* automated mode | Automation begins with first Pod; maximum delivery is more constrained with first Pod for safety Estimates TDI based on the programmed total basal insulin | TDI-based insulin automation Adjustable glucose targets of 110–150 mg/dL in 10-mg/dL increments, personalized for different times of day | TDI updated with every Pod change (approximately every 72 hours) | ICR, ICF, glucose targets, duration of insulin action (DIA) | Automated Mode: Limited: Static basal rate determined by system without any adjustments based on CGM values; activates when CGM values are missing (e.g., during sensor warm-up) and resumes full automated mode automatically once CGM values return. Activity: Set for 1- to 24-hour duration, with glucose target of 150 mg/dL and reduced insulin delivery |
| Medtronic MiniMed 670G/770G,† auto mode | 48-Hour warm-up period with insulin delivery in manual mode required before user can activate auto mode | TDI-based insulin automation Glucose target: 120 mg/dL; nonadjustable | TDI updated every 6 days at midnight | ICR, DIA | Safe Basal: Static basal rate determined by system without any adjustments based on CGM values Temp Target: Set for 2- to 12-hour duration with glucose target of 150 mg/dL |
| t:slim X2 with Control-IQ | Weight and TDI programmed into pump before activating automation; used at onboarding to initiate automation Programmed TDI used primarily for 2-hour maximum delivery constraints (50% TDI in 2-hour period) built into system for safety purposes | Adjusts pre-programmed basal rates Target glucose range: 112.5– 160 mg/dL; nonadjustable Auto-correction boluses: maximum 1/hour only if there is no user-initiated bolus in the past hour; 60% of calculated correction dose using a fixed target of 110 mg/dL | Actual TDI tracked by algorithm and primarily used to scale basal adjustments | ICR, ICF, basal rates | Sleep Activity: Narrows target glucose range to 112.5–120 mg/dL with no automated correction boluses; can program a sleep schedule or start/stop manually Exercise Activity: Changes glucose target to 140–160 mg/dL; manual start/stop—cannot program a duration of use |
| Medtronic MiniMed 780G,* auto mode | 48-hour warm-up period with insulin delivery in manual mode before user can activate auto mode | TDI-based insulin automation Glucose target: 100 or 120 mg/dL Auto-correction boluses: maximum every 5 minutes | TDI updated every 6 days at midnight | ICR, DIA, glucose target | Safe Basal: Static basal rate determined by system without any adjustments based on CGM values Temp Target: Set for 2- to 12-hour duration with glucose target of 150 mg/dL |
| AID System . | Onboarding . | AID Strategy . | Automation Adaptivity . | Adjustable Parameters . | System Features . |
|---|---|---|---|---|---|
| Insulet Omnipod 5 System,* automated mode | Automation begins with first Pod; maximum delivery is more constrained with first Pod for safety Estimates TDI based on the programmed total basal insulin | TDI-based insulin automation Adjustable glucose targets of 110–150 mg/dL in 10-mg/dL increments, personalized for different times of day | TDI updated with every Pod change (approximately every 72 hours) | ICR, ICF, glucose targets, duration of insulin action (DIA) | Automated Mode: Limited: Static basal rate determined by system without any adjustments based on CGM values; activates when CGM values are missing (e.g., during sensor warm-up) and resumes full automated mode automatically once CGM values return. Activity: Set for 1- to 24-hour duration, with glucose target of 150 mg/dL and reduced insulin delivery |
| Medtronic MiniMed 670G/770G,† auto mode | 48-Hour warm-up period with insulin delivery in manual mode required before user can activate auto mode | TDI-based insulin automation Glucose target: 120 mg/dL; nonadjustable | TDI updated every 6 days at midnight | ICR, DIA | Safe Basal: Static basal rate determined by system without any adjustments based on CGM values Temp Target: Set for 2- to 12-hour duration with glucose target of 150 mg/dL |
| t:slim X2 with Control-IQ | Weight and TDI programmed into pump before activating automation; used at onboarding to initiate automation Programmed TDI used primarily for 2-hour maximum delivery constraints (50% TDI in 2-hour period) built into system for safety purposes | Adjusts pre-programmed basal rates Target glucose range: 112.5– 160 mg/dL; nonadjustable Auto-correction boluses: maximum 1/hour only if there is no user-initiated bolus in the past hour; 60% of calculated correction dose using a fixed target of 110 mg/dL | Actual TDI tracked by algorithm and primarily used to scale basal adjustments | ICR, ICF, basal rates | Sleep Activity: Narrows target glucose range to 112.5–120 mg/dL with no automated correction boluses; can program a sleep schedule or start/stop manually Exercise Activity: Changes glucose target to 140–160 mg/dL; manual start/stop—cannot program a duration of use |
| Medtronic MiniMed 780G,* auto mode | 48-hour warm-up period with insulin delivery in manual mode before user can activate auto mode | TDI-based insulin automation Glucose target: 100 or 120 mg/dL Auto-correction boluses: maximum every 5 minutes | TDI updated every 6 days at midnight | ICR, DIA, glucose target | Safe Basal: Static basal rate determined by system without any adjustments based on CGM values Temp Target: Set for 2- to 12-hour duration with glucose target of 150 mg/dL |
This system was not commercially available in the United States but was undergoing FDA review at the time of writing.
Both systems used the same AID algorithm.