Time (min) . | No exogenous insulin . | . | . | Regular insulin . | . | . | Insulin aspart . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | Glucose (mg/dl) . | Insulin (μU/ml) . | C-peptide (ng/ml) . | Glucose (mg/dl) . | Insulin (μU/ml) . | C-peptide (ng/ml) . | Glucose (mg/dl) . | Insulin (μU/ml) . | C-peptide (ng/ml) . | ||||||
−30 | 93.7 ± 3.1 | 14.4 ± 3.6 | 2.5 ± 0.4 | 93.0 ± 2.5 | 16.7 ± 3.1 | 2.3 ± 0.2 | 94.3 ± 2.7 | 15.2 ± 2.9 | 2.6 ± 0.4 | ||||||
0 | 93.5 ± 3.4 | 14.6 ± 3.3 | 2.5 ± 0.4 | 89.6 ± 2.5 | 18.2 ± 3.8* | 2.5 ± 0.4 | 93.0 ± 2.6 | 14.6 ± 3.1† | 2.6 ± 0.4 | ||||||
15 | 91.7 ± 2.7 | 16.0 ± 2.8 | 2.5 ± 0.3 | 87.3 ± 3.0‡ | 28.1 ± 6.9‡ | 2.5 ± 0.4 | 90.5 ± 2.6 | 20.0 ± 2.9‡ | 2.6 ± 0.3 | ||||||
30 | 101.7 ± 2.9 | 37.4 ± 3.9 | 4.0 ± 0.4 | 101.8 ± 2.9 | 51.5 ± 7.4‡ | 4.2 ± 0.4 | 102.2 ± 3.8 | 56.1 ± 6.5* | 4.2 ± 0.4 | ||||||
60 | 122.8 ± 3.0 | 72.3 ± 9.7 | 6.8 ± 0.7 | 115.8 ± 2.9‡ | 84.7 ± 10.8‡ | 5.8 ± 0.4 | 111.6 ± 3.9* | 95.9 ± 10.9* | 5.5 ± 0.3‡ | ||||||
90 | 112.8 ± 2.8 | 53.9 ± 8.6 | 6.2 ± 0.6 | 108.4 ± 2.6‡ | 68.2 ± 10.4‡ | 5.8 ± 0.5 | 103.3 ± 4.3‡ | 77.4 ± 8.8* | 5.4 ± 0.5 | ||||||
120 | 102.5 ± 2.5 | 35.6 ± 6.2 | 5.4 ± 0.7 | 100.6 ± 2.5 | 55.2 ± 9.4* | 5.4 ± 0.6 | 93.1 ± 3.5* | 51.7 ± 9.8* | 4.8 ± 0.7 | ||||||
180 | 85.1 ± 2.1 | 20.0 ± 4.1 | 3.9 ± 0.5 | 79.9 ± 2.6‡ | 26.9 ± 4.5‡ | 3.1 ± 0.4 | 72.5 ± 3.4*† | 24.6 ± 4.6 | 2.7 ± 0.4*† | ||||||
240 | 74.7 ± 1.7 | 11.2 ± 3.0 | 2.6 ± 0.5 | 66.7 ± 2.0* | 18.8 ± 3.3* | 1.8 ± 0.4* | 65.5 ± 2.0* | 15.4 ± 1.9‡ | 1.5 ± 0.2*† |
Time (min) . | No exogenous insulin . | . | . | Regular insulin . | . | . | Insulin aspart . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | Glucose (mg/dl) . | Insulin (μU/ml) . | C-peptide (ng/ml) . | Glucose (mg/dl) . | Insulin (μU/ml) . | C-peptide (ng/ml) . | Glucose (mg/dl) . | Insulin (μU/ml) . | C-peptide (ng/ml) . | ||||||
−30 | 93.7 ± 3.1 | 14.4 ± 3.6 | 2.5 ± 0.4 | 93.0 ± 2.5 | 16.7 ± 3.1 | 2.3 ± 0.2 | 94.3 ± 2.7 | 15.2 ± 2.9 | 2.6 ± 0.4 | ||||||
0 | 93.5 ± 3.4 | 14.6 ± 3.3 | 2.5 ± 0.4 | 89.6 ± 2.5 | 18.2 ± 3.8* | 2.5 ± 0.4 | 93.0 ± 2.6 | 14.6 ± 3.1† | 2.6 ± 0.4 | ||||||
15 | 91.7 ± 2.7 | 16.0 ± 2.8 | 2.5 ± 0.3 | 87.3 ± 3.0‡ | 28.1 ± 6.9‡ | 2.5 ± 0.4 | 90.5 ± 2.6 | 20.0 ± 2.9‡ | 2.6 ± 0.3 | ||||||
30 | 101.7 ± 2.9 | 37.4 ± 3.9 | 4.0 ± 0.4 | 101.8 ± 2.9 | 51.5 ± 7.4‡ | 4.2 ± 0.4 | 102.2 ± 3.8 | 56.1 ± 6.5* | 4.2 ± 0.4 | ||||||
60 | 122.8 ± 3.0 | 72.3 ± 9.7 | 6.8 ± 0.7 | 115.8 ± 2.9‡ | 84.7 ± 10.8‡ | 5.8 ± 0.4 | 111.6 ± 3.9* | 95.9 ± 10.9* | 5.5 ± 0.3‡ | ||||||
90 | 112.8 ± 2.8 | 53.9 ± 8.6 | 6.2 ± 0.6 | 108.4 ± 2.6‡ | 68.2 ± 10.4‡ | 5.8 ± 0.5 | 103.3 ± 4.3‡ | 77.4 ± 8.8* | 5.4 ± 0.5 | ||||||
120 | 102.5 ± 2.5 | 35.6 ± 6.2 | 5.4 ± 0.7 | 100.6 ± 2.5 | 55.2 ± 9.4* | 5.4 ± 0.6 | 93.1 ± 3.5* | 51.7 ± 9.8* | 4.8 ± 0.7 | ||||||
180 | 85.1 ± 2.1 | 20.0 ± 4.1 | 3.9 ± 0.5 | 79.9 ± 2.6‡ | 26.9 ± 4.5‡ | 3.1 ± 0.4 | 72.5 ± 3.4*† | 24.6 ± 4.6 | 2.7 ± 0.4*† | ||||||
240 | 74.7 ± 1.7 | 11.2 ± 3.0 | 2.6 ± 0.5 | 66.7 ± 2.0* | 18.8 ± 3.3* | 1.8 ± 0.4* | 65.5 ± 2.0* | 15.4 ± 1.9‡ | 1.5 ± 0.2*† |
Data are means ± SE.
P = 0.01;
P < 0.05 vs. meal using regular human insulin;
P < 0.05 vs. meal with no exogenous insulin.