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Table 2—

Glucose, insulin, and C-peptide during three meal tests

Time (min)No exogenous insulin
Regular insulin
Insulin aspart
Glucose (mg/dl)Insulin (μU/ml)C-peptide (ng/ml)Glucose (mg/dl)Insulin (μU/ml)C-peptide (ng/ml)Glucose (mg/dl)Insulin (μU/ml)C-peptide (ng/ml)
−30 93.7 ± 3.1 14.4 ± 3.6 2.5 ± 0.4 93.0 ± 2.5 16.7 ± 3.1 2.3 ± 0.2 94.3 ± 2.7 15.2 ± 2.9 2.6 ± 0.4 
93.5 ± 3.4 14.6 ± 3.3 2.5 ± 0.4 89.6 ± 2.5 18.2 ± 3.8* 2.5 ± 0.4 93.0 ± 2.6 14.6 ± 3.1 2.6 ± 0.4 
15 91.7 ± 2.7 16.0 ± 2.8 2.5 ± 0.3 87.3 ± 3.0 28.1 ± 6.9 2.5 ± 0.4 90.5 ± 2.6 20.0 ± 2.9 2.6 ± 0.3 
30 101.7 ± 2.9 37.4 ± 3.9 4.0 ± 0.4 101.8 ± 2.9 51.5 ± 7.4 4.2 ± 0.4 102.2 ± 3.8 56.1 ± 6.5* 4.2 ± 0.4 
60 122.8 ± 3.0 72.3 ± 9.7 6.8 ± 0.7 115.8 ± 2.9 84.7 ± 10.8 5.8 ± 0.4 111.6 ± 3.9* 95.9 ± 10.9* 5.5 ± 0.3 
90 112.8 ± 2.8 53.9 ± 8.6 6.2 ± 0.6 108.4 ± 2.6 68.2 ± 10.4 5.8 ± 0.5 103.3 ± 4.3 77.4 ± 8.8* 5.4 ± 0.5 
120 102.5 ± 2.5 35.6 ± 6.2 5.4 ± 0.7 100.6 ± 2.5 55.2 ± 9.4* 5.4 ± 0.6 93.1 ± 3.5* 51.7 ± 9.8* 4.8 ± 0.7 
180 85.1 ± 2.1 20.0 ± 4.1 3.9 ± 0.5 79.9 ± 2.6 26.9 ± 4.5 3.1 ± 0.4 72.5 ± 3.4* 24.6 ± 4.6 2.7 ± 0.4* 
240 74.7 ± 1.7 11.2 ± 3.0 2.6 ± 0.5 66.7 ± 2.0* 18.8 ± 3.3* 1.8 ± 0.4* 65.5 ± 2.0* 15.4 ± 1.9 1.5 ± 0.2* 
Time (min)No exogenous insulin
Regular insulin
Insulin aspart
Glucose (mg/dl)Insulin (μU/ml)C-peptide (ng/ml)Glucose (mg/dl)Insulin (μU/ml)C-peptide (ng/ml)Glucose (mg/dl)Insulin (μU/ml)C-peptide (ng/ml)
−30 93.7 ± 3.1 14.4 ± 3.6 2.5 ± 0.4 93.0 ± 2.5 16.7 ± 3.1 2.3 ± 0.2 94.3 ± 2.7 15.2 ± 2.9 2.6 ± 0.4 
93.5 ± 3.4 14.6 ± 3.3 2.5 ± 0.4 89.6 ± 2.5 18.2 ± 3.8* 2.5 ± 0.4 93.0 ± 2.6 14.6 ± 3.1 2.6 ± 0.4 
15 91.7 ± 2.7 16.0 ± 2.8 2.5 ± 0.3 87.3 ± 3.0 28.1 ± 6.9 2.5 ± 0.4 90.5 ± 2.6 20.0 ± 2.9 2.6 ± 0.3 
30 101.7 ± 2.9 37.4 ± 3.9 4.0 ± 0.4 101.8 ± 2.9 51.5 ± 7.4 4.2 ± 0.4 102.2 ± 3.8 56.1 ± 6.5* 4.2 ± 0.4 
60 122.8 ± 3.0 72.3 ± 9.7 6.8 ± 0.7 115.8 ± 2.9 84.7 ± 10.8 5.8 ± 0.4 111.6 ± 3.9* 95.9 ± 10.9* 5.5 ± 0.3 
90 112.8 ± 2.8 53.9 ± 8.6 6.2 ± 0.6 108.4 ± 2.6 68.2 ± 10.4 5.8 ± 0.5 103.3 ± 4.3 77.4 ± 8.8* 5.4 ± 0.5 
120 102.5 ± 2.5 35.6 ± 6.2 5.4 ± 0.7 100.6 ± 2.5 55.2 ± 9.4* 5.4 ± 0.6 93.1 ± 3.5* 51.7 ± 9.8* 4.8 ± 0.7 
180 85.1 ± 2.1 20.0 ± 4.1 3.9 ± 0.5 79.9 ± 2.6 26.9 ± 4.5 3.1 ± 0.4 72.5 ± 3.4* 24.6 ± 4.6 2.7 ± 0.4* 
240 74.7 ± 1.7 11.2 ± 3.0 2.6 ± 0.5 66.7 ± 2.0* 18.8 ± 3.3* 1.8 ± 0.4* 65.5 ± 2.0* 15.4 ± 1.9 1.5 ± 0.2* 

Data are means ± SE.

*

P = 0.01;

P < 0.05 vs. meal using regular human insulin;

P < 0.05 vs. meal with no exogenous insulin.

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