. | Mutation inherited from . | . | P . | |
---|---|---|---|---|
. | Mother . | Father . | . | |
All carriers | ||||
n | 56 | 45 | ||
Diabetes diagnosed by age 20 years (%) | 64 | 33 | 0.001 | |
Autoantibodies (%)* | 4 | 10 | NS | |
Insulin-treated diabetes (%) | 52 | 29 | 0.02 | |
Carriers treated with insulin | ||||
n | 26† | 10† | ||
Insulin dose (units/kg) | 0.44 ± 0.24 | 0.39 ± 0.16 | NS | |
Fasting C-peptide <0.2 ng/ml (%)‡ | 15 | 10 | NS | |
Remaining carriers | ||||
n | 27 | 32 | ||
Fasting glucose (mg/dl) | 116 ± 42 | 134 ± 45 | NS | |
2-h glucose (mg/dl) | 273 ± 102 | 234 ± 89 | NS | |
Fasting insulin (μU/ml) | 6.1 ± 2.1 | 6.8 ± 2.5 | NS§ | |
2-h insulin (μU/ml) | 10.3 ± 6.3 | 13.4 ± 7.6 | NS§ | |
2-h insulin sensitivity index | 93 ± 73 | 103 ± 110 | NS§ | |
Non carriers | ||||
n | 17 | 27 | ||
Fasting glucose (mg/dl) | 89 ± 10‖ | 85 ± 13‖ | NS | |
2-h glucose (mg/dl) | 100 ± 21‖ | 92 ± 26‖ | NS | |
Fasting insulin (μU/ml) | 8.9 ± 4.8‖ | 12.0 ± 9.0‖ | NS§ | |
2-h insulin (μU/ml) | 38.6 ± 29.0‖ | 30.4 ± 38.5‖ | NS§ | |
2-h insulin sensitivity index | 109 ± 146 | 148 ± 133 | NS§ |
. | Mutation inherited from . | . | P . | |
---|---|---|---|---|
. | Mother . | Father . | . | |
All carriers | ||||
n | 56 | 45 | ||
Diabetes diagnosed by age 20 years (%) | 64 | 33 | 0.001 | |
Autoantibodies (%)* | 4 | 10 | NS | |
Insulin-treated diabetes (%) | 52 | 29 | 0.02 | |
Carriers treated with insulin | ||||
n | 26† | 10† | ||
Insulin dose (units/kg) | 0.44 ± 0.24 | 0.39 ± 0.16 | NS | |
Fasting C-peptide <0.2 ng/ml (%)‡ | 15 | 10 | NS | |
Remaining carriers | ||||
n | 27 | 32 | ||
Fasting glucose (mg/dl) | 116 ± 42 | 134 ± 45 | NS | |
2-h glucose (mg/dl) | 273 ± 102 | 234 ± 89 | NS | |
Fasting insulin (μU/ml) | 6.1 ± 2.1 | 6.8 ± 2.5 | NS§ | |
2-h insulin (μU/ml) | 10.3 ± 6.3 | 13.4 ± 7.6 | NS§ | |
2-h insulin sensitivity index | 93 ± 73 | 103 ± 110 | NS§ | |
Non carriers | ||||
n | 17 | 27 | ||
Fasting glucose (mg/dl) | 89 ± 10‖ | 85 ± 13‖ | NS | |
2-h glucose (mg/dl) | 100 ± 21‖ | 92 ± 26‖ | NS | |
Fasting insulin (μU/ml) | 8.9 ± 4.8‖ | 12.0 ± 9.0‖ | NS§ | |
2-h insulin (μU/ml) | 38.6 ± 29.0‖ | 30.4 ± 38.5‖ | NS§ | |
2-h insulin sensitivity index | 109 ± 146 | 148 ± 133 | NS§ |
Five subjects were GAD+ and one was IA2+. One was normoglycemic (age 14 years), whereas the remaining five had insulin-treated diabetes (one of the five had undetectable insulin secretion). Diabetes duration was very long (30–50 years), except for one with only 7 years’ duration. Antibody results were not available for 13 subjects.
Insulin dose and C-peptide values are unavailable for three subjects in each group.
No endogenous insulin secretion.
Significance test performed on log-transformed data,
difference between carriers and noncarriers significant (P < 0.05).