Land cover class . | Area radius* . | Multiple autoantibody positivity . | Type 1 diabetes . | |||
---|---|---|---|---|---|---|
OR (95% CI) . | P value . | OR (95% CI) . | P value . | |||
CORINE 2012 data | ||||||
Agriculture | ||||||
50 m | 0.17 (0.03–1.13) | 0.07 | 0.16 (0.02–1.52) | 0.11 | ||
100 m | 0.64 (0.28–1.44) | 0.28 | 0.49 (0.18–1.37) | 0.18 | ||
250 m | 0.64 (0.34–1.23) | 0.18 | 0.46 (0.20–1.04) | 0.06 | ||
500 m | 0.68 (0.36–1.27) | 0.23 | 0.51 (0.24–1.12) | 0.09 | ||
1,500 m | 0.54 (0.27–1.06) | 0.08 | 0.37 (0.16–0.87) | 0.02 | ||
Built environment | ||||||
50 m | 1.21 (0.63–2.30) | 0.57 | 1.04 (0.49–2.22) | 0.91 | ||
100 m | 1.15 (0.75–1.77) | 0.53 | 1.06 (0.64–1.76) | 0.83 | ||
250 m | 1.30 (0.85–1.98) | 0.22 | 1.18 (0.72–1.94) | 0.52 | ||
500 m | 1.32 (0.85–2.04) | 0.22 | 1.30 (0.77–2.18) | 0.33 | ||
1,500 m | 1.69 (1.03–2.79) | 0.04 | 1.66 (0.92–3.02) | 0.09 | ||
CORINE 2000 data | ||||||
Agriculture | ||||||
50 m | 0.37 (0.12–1.10) | 0.07 | 0.39 (0.11–1.39) | 0.15 | ||
100 m | 0.44 (0.21–0.94) | 0.03 | 0.39 (0.16–0.98) | 0.045 | ||
250 m | 0.51 (0.28–0.95) | 0.03 | 0.43 (0.20–0.91) | 0.03 | ||
500 m | 0.56 (0.31–1.02) | 0.06 | 0.50 (0.24–1.04) | 0.06 | ||
1,500 m | 0.56 (0.29–1.08) | 0.08 | 0.44 (0.20–0.99) | 0.046 | ||
Built environment | ||||||
50 m | 2.00 (1.17–3.41) | 0.01 | 1.52 (0.85–2.72) | 0.16 | ||
100 m | 1.55 (1.01–2.37) | 0.045 | 1.43 (0.87–2.36) | 0.16 | ||
250 m | 1.29 (0.88–1.90) | 0.19 | 1.20 (0.77–1.89) | 0.42 | ||
500 m | 1.37 (0.92–2.03) | 0.12 | 1.33 (0.83–2.12) | 0.24 | ||
1,500 m | 1.67 (1.07–2.62) | 0.02 | 1.61 (0.95–2.74) | 0.08 |
Land cover class . | Area radius* . | Multiple autoantibody positivity . | Type 1 diabetes . | |||
---|---|---|---|---|---|---|
OR (95% CI) . | P value . | OR (95% CI) . | P value . | |||
CORINE 2012 data | ||||||
Agriculture | ||||||
50 m | 0.17 (0.03–1.13) | 0.07 | 0.16 (0.02–1.52) | 0.11 | ||
100 m | 0.64 (0.28–1.44) | 0.28 | 0.49 (0.18–1.37) | 0.18 | ||
250 m | 0.64 (0.34–1.23) | 0.18 | 0.46 (0.20–1.04) | 0.06 | ||
500 m | 0.68 (0.36–1.27) | 0.23 | 0.51 (0.24–1.12) | 0.09 | ||
1,500 m | 0.54 (0.27–1.06) | 0.08 | 0.37 (0.16–0.87) | 0.02 | ||
Built environment | ||||||
50 m | 1.21 (0.63–2.30) | 0.57 | 1.04 (0.49–2.22) | 0.91 | ||
100 m | 1.15 (0.75–1.77) | 0.53 | 1.06 (0.64–1.76) | 0.83 | ||
250 m | 1.30 (0.85–1.98) | 0.22 | 1.18 (0.72–1.94) | 0.52 | ||
500 m | 1.32 (0.85–2.04) | 0.22 | 1.30 (0.77–2.18) | 0.33 | ||
1,500 m | 1.69 (1.03–2.79) | 0.04 | 1.66 (0.92–3.02) | 0.09 | ||
CORINE 2000 data | ||||||
Agriculture | ||||||
50 m | 0.37 (0.12–1.10) | 0.07 | 0.39 (0.11–1.39) | 0.15 | ||
100 m | 0.44 (0.21–0.94) | 0.03 | 0.39 (0.16–0.98) | 0.045 | ||
250 m | 0.51 (0.28–0.95) | 0.03 | 0.43 (0.20–0.91) | 0.03 | ||
500 m | 0.56 (0.31–1.02) | 0.06 | 0.50 (0.24–1.04) | 0.06 | ||
1,500 m | 0.56 (0.29–1.08) | 0.08 | 0.44 (0.20–0.99) | 0.046 | ||
Built environment | ||||||
50 m | 2.00 (1.17–3.41) | 0.01 | 1.52 (0.85–2.72) | 0.16 | ||
100 m | 1.55 (1.01–2.37) | 0.045 | 1.43 (0.87–2.36) | 0.16 | ||
250 m | 1.29 (0.88–1.90) | 0.19 | 1.20 (0.77–1.89) | 0.42 | ||
500 m | 1.37 (0.92–2.03) | 0.12 | 1.33 (0.83–2.12) | 0.24 | ||
1,500 m | 1.67 (1.07–2.62) | 0.02 | 1.61 (0.95–2.74) | 0.08 |
The bold data are statistically significant (P < 0.05). The proportion of agricultural area and built area around the dwelling was analyzed as a predictor of autoantibody positivity and type 1 diabetes using land cover data from the year 2012 and 2000 (CORINE 2012 and CORINE 2000 data, respectively). Children who developed multiple biochemical islet autoantibodies (n = 384) and type 1 diabetes (n = 271) were compared with autoantibody-negative children using logistic regression (n = 10,279).
Radius of the analyzed area around the home.