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Table 1

Baseline characteristics of the DCCT/EDIC participants by status of CVD or MACE over the combined DCCT/EDIC follow-up

 Any CVD*MACE**
Baseline characteristicsOverall (n = 1,441)No CVD (n = 1,202)With CVD (n = 239)P value^No MACE (n = 1,321)With MACE (n = 120)P value^
Age (years) 26.8 (7.1) 26.2 (7.1) 29.9 (6.3) <0.0001 26.5 (7.1) 30.3 (6.1) <0.0001 
Sex (% female) 47.2 47.8 43.9 0.1875 47.9 39.2 0.0419 
T1D duration (months) 69.8 (49.7) 67.9 (49.0) 79.4 (51.9) 0.0048 68.6 (49.1) 82.7 (54.3) 0.0103 
Family history of MI (%) 48.9 46.8 59.0 0.0011 48.4 53.3 0.8743 
Smoking (%) 18.5 16.6 28.0 0.0028 17.1 33.3 0.0003 
Systolic blood pressure (mmHg) 114.5 (11.4) 114.2 (11.3) 116.2 (11.4) 0.0105 114.3 (11.3) 116.7 (11.3) 0.0322 
Pulse (bpm) 76.1 (11.1) 75.8 (11.1) 77.6 (11.1) 0.0356 75.9 (11.1) 77.9 (11.2) 0.0904 
LDL (mg/dL) 109.7 (29.1) 107.9 (28.6) 118.8 (30.0) <0.0001 109.0 (28.9) 117.5 (30.2) 0.0008 
Triglycerides (mg/dL) 81.3 (47.5) 79.9 (46.7) 88.6 (50.7) 0.0069 80.1 (46.9) 94.8 (51.6) 0.0008 
HbA1c (%) 8.9 (1.6) 8.9 (1.6) 9.1 (1.6) 0.0116 8.9 (1.6) 9.2 (1.7) 0.0116 
HbA1c (mmol/mol) 74 (17.5) 74 (17.5) 76 (17.5) 0.0116 74 (17.5) 77 (18.6) 0.0116 
AER (mg/24 h) 15.9 (18.8) 15.7 (18.7) 17.0 (19.0) 0.4179 15.8 (18.5) 17.8 (21.7) 0.3618 
eGFR (mL/min/1.73 m2126.1 (14.2) 126.6 (14.3) 123.9 (13.5) 0.0040 126.4 (14.2) 122.7 (14.0) 0.0031 
 Any CVD*MACE**
Baseline characteristicsOverall (n = 1,441)No CVD (n = 1,202)With CVD (n = 239)P value^No MACE (n = 1,321)With MACE (n = 120)P value^
Age (years) 26.8 (7.1) 26.2 (7.1) 29.9 (6.3) <0.0001 26.5 (7.1) 30.3 (6.1) <0.0001 
Sex (% female) 47.2 47.8 43.9 0.1875 47.9 39.2 0.0419 
T1D duration (months) 69.8 (49.7) 67.9 (49.0) 79.4 (51.9) 0.0048 68.6 (49.1) 82.7 (54.3) 0.0103 
Family history of MI (%) 48.9 46.8 59.0 0.0011 48.4 53.3 0.8743 
Smoking (%) 18.5 16.6 28.0 0.0028 17.1 33.3 0.0003 
Systolic blood pressure (mmHg) 114.5 (11.4) 114.2 (11.3) 116.2 (11.4) 0.0105 114.3 (11.3) 116.7 (11.3) 0.0322 
Pulse (bpm) 76.1 (11.1) 75.8 (11.1) 77.6 (11.1) 0.0356 75.9 (11.1) 77.9 (11.2) 0.0904 
LDL (mg/dL) 109.7 (29.1) 107.9 (28.6) 118.8 (30.0) <0.0001 109.0 (28.9) 117.5 (30.2) 0.0008 
Triglycerides (mg/dL) 81.3 (47.5) 79.9 (46.7) 88.6 (50.7) 0.0069 80.1 (46.9) 94.8 (51.6) 0.0008 
HbA1c (%) 8.9 (1.6) 8.9 (1.6) 9.1 (1.6) 0.0116 8.9 (1.6) 9.2 (1.7) 0.0116 
HbA1c (mmol/mol) 74 (17.5) 74 (17.5) 76 (17.5) 0.0116 74 (17.5) 77 (18.6) 0.0116 
AER (mg/24 h) 15.9 (18.8) 15.7 (18.7) 17.0 (19.0) 0.4179 15.8 (18.5) 17.8 (21.7) 0.3618 
eGFR (mL/min/1.73 m2126.1 (14.2) 126.6 (14.3) 123.9 (13.5) 0.0040 126.4 (14.2) 122.7 (14.0) 0.0031 

bpm, beats per minute.

*

Any CVD: composite time to first of any of the following: death from CVD, nonfatal MI, stroke, subclinical MI on electrocardiogram, confirmed angina, or the need for coronary artery revascularization.

**

MACE: composite of time to first of any of the following: nonfatal MI, nonfatal stroke, or death from CVD.

^

P values from unadjusted Cox proportional hazards models. Boldface type indicates significance at P < 0.05.

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