American Diabetes Association

Table 2

Incidence rate ratios (IRR) for predictors of ESKD and death: core model

	ESKD		Non-ESKD death
	IRR (95% CI)	P value	IRR (95% CI)	P value
Age (10 years)	0.83 (0.75; 0.92)	<0.001	—
Male sex (vs. female sex)	1.40 (1.11; 1.78)	0.005	5.47 (2.58; 11.61)	<0.001
Diabetes duration (10 years)	1.13 (1.02; 1.25)	0.022	1.11 (1.05; 1.16)	<0.001
eGFR (halving)	8.15 (6.88; 9.65)	<0.001	1.28 (1.11; 1.49)	<0.001
Microalbuminuria (vs. normoalbuminuria)	1.09 (0.76; 1.55)	0.643	1.64 (1.39; 1.94)	<0.001
Macroalbuminuria (vs. normoalbuminuria)	1.89 (1.32; 2.70)	<0.001	2.39 (1.88; 3.02)	<0.001
Systolic blood pressure (10 mmHg)	1.08 (1.03; 1.14)	0.004	0.90 (0.86; 0.93)	<0.001
HbA_1c (10 mmol/mol)	1.12 (1.03; 1.20)	0.005	1.10 (1.04; 1.15)	<0.001
Smoking (vs. no smoking)	1.27 (1.00; 1.62)	0.048	1.88 (1.63; 2.18)	<0.001
Previous CVD event (vs. no)	1.35 (1.05; 1.74)	0.019	1.93 (1.65; 2.25)	<0.001
Age (10 years), women	—		2.37 (2.18; 2.59)	<0.001
Age (10 years), men	—		1.92 (1.78; 2.07)	<0.001

	ESKD		Non-ESKD death
	IRR (95% CI)	P value	IRR (95% CI)	P value
Age (10 years)	0.83 (0.75; 0.92)	<0.001	—
Male sex (vs. female sex)	1.40 (1.11; 1.78)	0.005	5.47 (2.58; 11.61)	<0.001
Diabetes duration (10 years)	1.13 (1.02; 1.25)	0.022	1.11 (1.05; 1.16)	<0.001
eGFR (halving)	8.15 (6.88; 9.65)	<0.001	1.28 (1.11; 1.49)	<0.001
Microalbuminuria (vs. normoalbuminuria)	1.09 (0.76; 1.55)	0.643	1.64 (1.39; 1.94)	<0.001
Macroalbuminuria (vs. normoalbuminuria)	1.89 (1.32; 2.70)	<0.001	2.39 (1.88; 3.02)	<0.001
Systolic blood pressure (10 mmHg)	1.08 (1.03; 1.14)	0.004	0.90 (0.86; 0.93)	<0.001
HbA_1c (10 mmol/mol)	1.12 (1.03; 1.20)	0.005	1.10 (1.04; 1.15)	<0.001
Smoking (vs. no smoking)	1.27 (1.00; 1.62)	0.048	1.88 (1.63; 2.18)	<0.001
Previous CVD event (vs. no)	1.35 (1.05; 1.74)	0.019	1.93 (1.65; 2.25)	<0.001
Age (10 years), women	—		2.37 (2.18; 2.59)	<0.001
Age (10 years), men	—		1.92 (1.78; 2.07)	<0.001