. | . | BMI category at adolescence . | . | ||||||
---|---|---|---|---|---|---|---|---|---|
. | Total . | <5th percentile (underweight) . | 5th–49th percentile (low normal) . | 50th–74th percentile . | 75th–84th percentile . | 85th–94th percentile (overweight) . | Mild obesity . | Severe obesity . | P value for trend . |
Men | |||||||||
Incident cases, n | 1,490 | 44 | 302 | 217 | 139 | 292 | 353 | 143 | |
Mean follow-up ± SD (years) | 11.3 ± 6.1 | 12.0 ± 6.1 | 11.8 ± 6.1 | 11.2 ± 6.0 | 10.8 ± 6.0 | 10.3 ± 5.9 | 9.8 ± 5.8 | 8.8 ± 5.5 | <0.001 |
Person-years of follow-up | 9,412,455 | 753,711 | 4,158,394 | 2,136,497 | 851,800 | 902,214 | 491,455 | 118,382 | |
Incidence* (per 10−5 person-years) | 15.8 (15.0–16.7) | 5.8 (4.2–7.8) | 7.3 (6.5–8.1) | 10.2 (8.9–11.6) | 16.3 (13.7–9.3) | 32.3 (28.8–36.3) | 71.8 (64.5–79.7) | 120.9 (102–142) | 0.008 |
Mean age at end of follow-up ± SD (years) | 28.6 ± 6.1 | 29.5 ± 6.2 | 29.2 ± 6.1 | 28.5 ± 6.1 | 28.0 ± 6.1 | 27.6 ± 6.0 | 27.1 ± 5.9 | 26.1 ± 5.6 | <0.001 |
Mean age at diagnosis ± SD (years) | 30.0 ± 4.3 | 31.3 ± 4.0 | 30.4 ± 4.6 | 30.6 ± 4.1 | 30.8 ± 4.0 | 30.4 ± 4.0 | 29.3 ± 4.1 | 27.8 ± 4.6 | 0.015 |
Mean BMI at year of diagnosis ± SD (kg/m2) | 31.1 ± 6.3 | 23.7 ± 4.7 | 25.8 ± 4.3 | 29.7 ± 5.1 | 30.3 ± 4.6 | 31.9 ± 5.1 | 34.4 ± 5.5 | 37.3 ± 6.4 | <0.001 |
Overweight or obese at year of diagnosis, % | 83.8 | 36.4 | 52.7 | 85.7 | 92.8 | 93.8 | 97.5 | 98.1 | 0.008 |
HRadjusted† | 0.61 | 1 | 1.66 | 2.82 | 5.81 | 13.42 | 25.8 | ||
95% CI | 0.44–0.84 | 1.39–1.98 | 2.30–3.47 | 4.92–6.85 | 11.47–15.72 | 21.0–31.61 | |||
P value | 0.003 | 7.4 * 10−9 | 2.5 * 10−23 | 9.2 * 10−97 | 8.3 * 10−229 | 3.5 * 10−213 | |||
Women | |||||||||
Incident cases, n | 687 | 10 | 92 | 115 | 69 | 209 | 123 | 69 | |
Mean follow-up ± SD (years) | 10.8 ± 5.8 | 11.1 ± 5.7 | 11.2 ± 5.7 | 10.8 ± 5.8 | 10.5 ± 5.8 | 10.1 ± 5.8 | 9.6 ± 5.7 | 8.8 ± 5.4 | 0.001 |
Person-year follow-up | 6,407,296 | 308,543 | 2,797,131 | 1,686,554 | 691,622 | 665,386 | 202,436 | 55,624 | |
Incidence* (per 10−5 person-year) | 10.7 (9.9–11.6) | 3.2 (1.6–6.0) | 3.3 (2.7–4.0) | 6.8 (5.6–8.2) | 10.0 (7.8–12.6) | 31.4 (27.3–36.0) | 60.8 (50.5–72.5) | 124.4 (96.5–157) | 0.011 |
Age at end of follow-up ± SD (years) | 28.0 ± 5.9 | 28.4 ± 5.8 | 28.4 ± 5.8 | 28.0 ± 5.9 | 27.7 ± 5.9 | 27.3 ± 5.9 | 26.7 ± 5.8 | 26.0 ± 5.5 | <0.001 |
Mean age at diagnosis ± SD (years) | 27.7 ± 5.9 | 29.0 ± 3.8 | 29.0 ± 4.7 | 28.2 ± 4.3 | 28.0 ± 3.8 | 28.1 ± 4.0 | 28.0 ± 4.5 | 25.9 ± 4.7 | 0.181 |
Mean BMI at year of diagnosis ± SD (kg/m2) | 32.1 ± 7.2 | 23.0 ± 4.7 | 25.1 ± 5.2 | 28.5 ± 5.6 | 30.2 ± 5.0 | 32.7 ± 5.4 | 37.7 ± 6.6 | 39.3 ± 6.5 | <0.001 |
Overweight or obese at year of diagnosis, % | 82.3 | 25 | 46.4 | 70.3 | 86 | 91.1 | 98.1 | 100 | 0.001 |
HR adjusted† | 0.90 | 1 | 2.17 | 3.38 | 10.63 | 21.08 | 44.66 | ||
95% CI | 0.47–1.78 | 1.64–2.87 | 2.46–4.63 | 8.29–13.64 | 16.00–27.77 | 32.42–61.52 | |||
P value | 0.76 | 5.3 * 10−8 | 3.6 * 10−14 | 4.4 * 10−77 | 3.0 * 10−104 | 1.4 * 10−119 |
. | . | BMI category at adolescence . | . | ||||||
---|---|---|---|---|---|---|---|---|---|
. | Total . | <5th percentile (underweight) . | 5th–49th percentile (low normal) . | 50th–74th percentile . | 75th–84th percentile . | 85th–94th percentile (overweight) . | Mild obesity . | Severe obesity . | P value for trend . |
Men | |||||||||
Incident cases, n | 1,490 | 44 | 302 | 217 | 139 | 292 | 353 | 143 | |
Mean follow-up ± SD (years) | 11.3 ± 6.1 | 12.0 ± 6.1 | 11.8 ± 6.1 | 11.2 ± 6.0 | 10.8 ± 6.0 | 10.3 ± 5.9 | 9.8 ± 5.8 | 8.8 ± 5.5 | <0.001 |
Person-years of follow-up | 9,412,455 | 753,711 | 4,158,394 | 2,136,497 | 851,800 | 902,214 | 491,455 | 118,382 | |
Incidence* (per 10−5 person-years) | 15.8 (15.0–16.7) | 5.8 (4.2–7.8) | 7.3 (6.5–8.1) | 10.2 (8.9–11.6) | 16.3 (13.7–9.3) | 32.3 (28.8–36.3) | 71.8 (64.5–79.7) | 120.9 (102–142) | 0.008 |
Mean age at end of follow-up ± SD (years) | 28.6 ± 6.1 | 29.5 ± 6.2 | 29.2 ± 6.1 | 28.5 ± 6.1 | 28.0 ± 6.1 | 27.6 ± 6.0 | 27.1 ± 5.9 | 26.1 ± 5.6 | <0.001 |
Mean age at diagnosis ± SD (years) | 30.0 ± 4.3 | 31.3 ± 4.0 | 30.4 ± 4.6 | 30.6 ± 4.1 | 30.8 ± 4.0 | 30.4 ± 4.0 | 29.3 ± 4.1 | 27.8 ± 4.6 | 0.015 |
Mean BMI at year of diagnosis ± SD (kg/m2) | 31.1 ± 6.3 | 23.7 ± 4.7 | 25.8 ± 4.3 | 29.7 ± 5.1 | 30.3 ± 4.6 | 31.9 ± 5.1 | 34.4 ± 5.5 | 37.3 ± 6.4 | <0.001 |
Overweight or obese at year of diagnosis, % | 83.8 | 36.4 | 52.7 | 85.7 | 92.8 | 93.8 | 97.5 | 98.1 | 0.008 |
HRadjusted† | 0.61 | 1 | 1.66 | 2.82 | 5.81 | 13.42 | 25.8 | ||
95% CI | 0.44–0.84 | 1.39–1.98 | 2.30–3.47 | 4.92–6.85 | 11.47–15.72 | 21.0–31.61 | |||
P value | 0.003 | 7.4 * 10−9 | 2.5 * 10−23 | 9.2 * 10−97 | 8.3 * 10−229 | 3.5 * 10−213 | |||
Women | |||||||||
Incident cases, n | 687 | 10 | 92 | 115 | 69 | 209 | 123 | 69 | |
Mean follow-up ± SD (years) | 10.8 ± 5.8 | 11.1 ± 5.7 | 11.2 ± 5.7 | 10.8 ± 5.8 | 10.5 ± 5.8 | 10.1 ± 5.8 | 9.6 ± 5.7 | 8.8 ± 5.4 | 0.001 |
Person-year follow-up | 6,407,296 | 308,543 | 2,797,131 | 1,686,554 | 691,622 | 665,386 | 202,436 | 55,624 | |
Incidence* (per 10−5 person-year) | 10.7 (9.9–11.6) | 3.2 (1.6–6.0) | 3.3 (2.7–4.0) | 6.8 (5.6–8.2) | 10.0 (7.8–12.6) | 31.4 (27.3–36.0) | 60.8 (50.5–72.5) | 124.4 (96.5–157) | 0.011 |
Age at end of follow-up ± SD (years) | 28.0 ± 5.9 | 28.4 ± 5.8 | 28.4 ± 5.8 | 28.0 ± 5.9 | 27.7 ± 5.9 | 27.3 ± 5.9 | 26.7 ± 5.8 | 26.0 ± 5.5 | <0.001 |
Mean age at diagnosis ± SD (years) | 27.7 ± 5.9 | 29.0 ± 3.8 | 29.0 ± 4.7 | 28.2 ± 4.3 | 28.0 ± 3.8 | 28.1 ± 4.0 | 28.0 ± 4.5 | 25.9 ± 4.7 | 0.181 |
Mean BMI at year of diagnosis ± SD (kg/m2) | 32.1 ± 7.2 | 23.0 ± 4.7 | 25.1 ± 5.2 | 28.5 ± 5.6 | 30.2 ± 5.0 | 32.7 ± 5.4 | 37.7 ± 6.6 | 39.3 ± 6.5 | <0.001 |
Overweight or obese at year of diagnosis, % | 82.3 | 25 | 46.4 | 70.3 | 86 | 91.1 | 98.1 | 100 | 0.001 |
HR adjusted† | 0.90 | 1 | 2.17 | 3.38 | 10.63 | 21.08 | 44.66 | ||
95% CI | 0.47–1.78 | 1.64–2.87 | 2.46–4.63 | 8.29–13.64 | 16.00–27.77 | 32.42–61.52 | |||
P value | 0.76 | 5.3 * 10−8 | 3.6 * 10−14 | 4.4 * 10−77 | 3.0 * 10−104 | 1.4 * 10−119 |
Parentheses denote 95% CI.
The model was adjusted for age at study entry, birth year, education, and cognitive performance score.