. | HR (95% CI) . | P values . |
---|---|---|
Type of second antibody | ||
IAA or GADA | 1 (reference) | |
IA-2A | 3.08 (2.04–4.65) | <0.0001 |
ZnT8A | 0.81 (0.51–1.29) | 0.37 |
Age at first-appearing autoantibody (months) | 0.98 (0.97–0.99) | 0.001 |
Time from first to second autoantibody (months) | 0.97 (0.96–0.99) | 0.003 |
Sex | ||
Female | 1.52 (1.09–2.13) | 0.014 |
Male | 1 (reference) | |
Family history of T1D | ||
Mother with T1D | 1.55 (0.65–3.67) | 0.32 |
Father with T1D | 1.01 (0.60–1.70) | 0.97 |
Sibling with T1D | 0.92 (0.46–1.76) | 0.82 |
General population (no T1D history) | 1 (reference) | |
HLA-DR-DQ genotype | ||
DR3/4 | 1.70 (0.99–2.93) | 0.06 |
DR4/4 | 1 (reference) | |
DR4/8 | 1.32 (0.69–2.54) | 0.41 |
DR3/3 | 0.97 (0.44–2.15) | 0.94 |
FDR-specific* | 1.28 (0.35–4.63) | 0.71 |
Type of first antibody | ||
GADA only | 0.97 (0.66–1.43) | 0.89 |
IAA only | 1 (reference) |
. | HR (95% CI) . | P values . |
---|---|---|
Type of second antibody | ||
IAA or GADA | 1 (reference) | |
IA-2A | 3.08 (2.04–4.65) | <0.0001 |
ZnT8A | 0.81 (0.51–1.29) | 0.37 |
Age at first-appearing autoantibody (months) | 0.98 (0.97–0.99) | 0.001 |
Time from first to second autoantibody (months) | 0.97 (0.96–0.99) | 0.003 |
Sex | ||
Female | 1.52 (1.09–2.13) | 0.014 |
Male | 1 (reference) | |
Family history of T1D | ||
Mother with T1D | 1.55 (0.65–3.67) | 0.32 |
Father with T1D | 1.01 (0.60–1.70) | 0.97 |
Sibling with T1D | 0.92 (0.46–1.76) | 0.82 |
General population (no T1D history) | 1 (reference) | |
HLA-DR-DQ genotype | ||
DR3/4 | 1.70 (0.99–2.93) | 0.06 |
DR4/4 | 1 (reference) | |
DR4/8 | 1.32 (0.69–2.54) | 0.41 |
DR3/3 | 0.97 (0.44–2.15) | 0.94 |
FDR-specific* | 1.28 (0.35–4.63) | 0.71 |
Type of first antibody | ||
GADA only | 0.97 (0.66–1.43) | 0.89 |
IAA only | 1 (reference) |
FDR-specific HLA-DR-DQ genotypes are the following: DR4/4b, DR4/1, DR4/9, DR4/13, and DR3/9.