. | C-statistic (95% CI) . | ΔC-statistic (95% CI) . |
---|---|---|
Base model* with comorbidity burden (≥3 comorbidities) | 0.7024 (0.6781, 0.7267) | — |
hs-cTnI ≥85th percentile | 0.7170 (0.6925, 0.7415) | 0.0146 (0.0051, 0.0242)† |
log2(hs-cTnI) | 0.7243 (0.6999, 0.7486) | 0.0219 (0.0113, 0.0325)† |
hs-cTnT ≥85th percentile | 0.7220 (0.6977, 0.7464)a | 0.0197 (0.0091, 0.0302)† |
log2(hs-cTnT) | 0.7344 (0.7103, 0.7584)b | 0.0320 (0.0180, 0.0459)† |
Base model* with comorbidity burden (≥3 comorbidities or dementia or frailty) | 0.7046 (0.6804, 0.7287) | — |
hs-cTnI ≥85th percentile | 0.7201 (0.6958, 0.7445) | 0.0156 (0.0060, 0.0252)† |
log2(hs-cTnI) | 0.7269 (0.7027, 0.7511) | 0.0223 (0.0117, 0.0330)† |
hs-cTnT ≥85th percentile | 0.7238 (0.6995, 0.7480)c | 0.0192 (0.0088, 0.0296)† |
log2(hs-cTnT) | 0.7363 (0.7123, 0.7602)d | 0.0317 (0.0180, 0.0455)† |
. | C-statistic (95% CI) . | ΔC-statistic (95% CI) . |
---|---|---|
Base model* with comorbidity burden (≥3 comorbidities) | 0.7024 (0.6781, 0.7267) | — |
hs-cTnI ≥85th percentile | 0.7170 (0.6925, 0.7415) | 0.0146 (0.0051, 0.0242)† |
log2(hs-cTnI) | 0.7243 (0.6999, 0.7486) | 0.0219 (0.0113, 0.0325)† |
hs-cTnT ≥85th percentile | 0.7220 (0.6977, 0.7464)a | 0.0197 (0.0091, 0.0302)† |
log2(hs-cTnT) | 0.7344 (0.7103, 0.7584)b | 0.0320 (0.0180, 0.0459)† |
Base model* with comorbidity burden (≥3 comorbidities or dementia or frailty) | 0.7046 (0.6804, 0.7287) | — |
hs-cTnI ≥85th percentile | 0.7201 (0.6958, 0.7445) | 0.0156 (0.0060, 0.0252)† |
log2(hs-cTnI) | 0.7269 (0.7027, 0.7511) | 0.0223 (0.0117, 0.0330)† |
hs-cTnT ≥85th percentile | 0.7238 (0.6995, 0.7480)c | 0.0192 (0.0088, 0.0296)† |
log2(hs-cTnT) | 0.7363 (0.7123, 0.7602)d | 0.0317 (0.0180, 0.0455)† |
Age, male sex, race-center, current smoking, systolic blood pressure, diastolic blood pressure, antihypertensive medication use, total cholesterol, HDL cholesterol, cholesterol-lowering medication use, and hemoglobin A1c.
P < 0.01.
P = 0.35 compared with base model with comorbidity burden (≥3 comorbidities) + hs-cTnI ≥85th percentile.
P = 0.11 compared with base model with comorbidity burden (≥3 comorbidities) + log2(hs-cTnI).
P = 0.47 compared with base model with comorbidity burden (≥3 comorbidities or dementia or frailty) + hs-cTnI ≥85th percentile.
P = 0.13 compared with base model with comorbidity burden (≥3 comorbidities or dementia or frailty) + log2(hs-cTnI).