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TABLE 4

Association Between Time-Varying Changes in Medication Orders After A1C Measurement and Acute Hypoglycemic Events

Model 1: Univariate ModelModel 2: Multivariate Model*
HR (95% CI)PHR (95% CI)P
Change in medication after A1C measurement  <0.0001  0.01 
 Change in insulin medication orders 2.35 (1.76–3.15)  1.48 (1.08–2.03)  
 Change in secretagogue medication orders; no change to insulin 0.73 (0.42–1.26)  0.78 (0.45–1.34)  
 Change in metformin only 0.15 (0.04–0.60)  0.22 (0.05–0.90)  
 Other glucose-lowering medication change 0.65 (0.24–1.75)  0.66 (0.25–1.76)  
 No change in medication orders REF  REF  
Model 1: Univariate ModelModel 2: Multivariate Model*
HR (95% CI)PHR (95% CI)P
Change in medication after A1C measurement  <0.0001  0.01 
 Change in insulin medication orders 2.35 (1.76–3.15)  1.48 (1.08–2.03)  
 Change in secretagogue medication orders; no change to insulin 0.73 (0.42–1.26)  0.78 (0.45–1.34)  
 Change in metformin only 0.15 (0.04–0.60)  0.22 (0.05–0.90)  
 Other glucose-lowering medication change 0.65 (0.24–1.75)  0.66 (0.25–1.76)  
 No change in medication orders REF  REF  

REF, reference.

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