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TABLE 3

Association Between Traditional Risk Factors and Acute Hypoglycemic Events

Model 1: Univariate ModelModel 2: Multivariate Model*
HR (95% CI)PHR (95% CI)P
Age category, years  0.48  0.58 
 <60 REF  REF  
 60 to <70 0.98 (0.68–1.43)  0.97 (0.68–1.39)  
 70 to <80 0.98 (0.65–1.48)  0.90 (0.59–1.37)  
 ≥80 1.34 (0.87–2.06)  1.24 (0.77–2.02)  
Female sex 1.05 (0.78–1.41) 0.76 0.99 (0.73–1.32) 0.92 
Race/ethnicity  <0.0001  0.003 
 Non-Hispanic White REF  REF  
 Non-Hispanic Asian 0.93 (0.62–1.39)  0.96 (0.65–1.41)  
 Non-Hispanic Black 2.52 (1.70–3.74)  2.10 (1.36–3.22)  
 Hispanic 1.34 (0.79–2.25)  1.24 (0.75–2.04)  
 Other/unknown 0.92 (0.54–1.56)  0.98 (0.57–1.67)  
A1C category, %  <0.0001  0.10 
 <6 1.86 (1.19–2.90)  1.56 (0.99, 2.46)  
 6–6.9 REF  REF  
 7–7.9 1.06 (0.72–1.57)  0.95 (0.65–1.41)  
 8–8.9 2.01 (1.31–3.07)  1.50 (0.97–2.32)  
 ≥9 1.83 (1.20–2.78)  1.28 (0.82–1.99)  
CKD (Stage 4–5)  <0.0001  <0.0001 
 No REF  REF  
 Yes 5.17 (3.62–7.39)  2.96 (2.01–4.35)  
Medication orders, pre-A1C  <0.0001  <0.0001 
 Any insulin 3.41 (1.69–6.86)  2.76 (1.37–5.56)  
 Any secretagogues, no insulin 1.53 (0.76–3.07)  1.41 (0.70–2.84)  
 Metformin only 0.38 (0.16–0.90)  0.39 (0.16–0.93)  
 Other glucose-lowering medication REF  REF  
Insurance  <0.0001  0.001 
 Private REF  REF  
 Medicare 2.73 (1.81–4.12)  2.38 (1.56–3.61)  
 Medicaid 2.39 (1.43–4.00)  1.93 (1.15–3.24)  
 Other/Unknown 3.05 (1.40–6.68)  2.84 (1.31–6.15)  
Model 1: Univariate ModelModel 2: Multivariate Model*
HR (95% CI)PHR (95% CI)P
Age category, years  0.48  0.58 
 <60 REF  REF  
 60 to <70 0.98 (0.68–1.43)  0.97 (0.68–1.39)  
 70 to <80 0.98 (0.65–1.48)  0.90 (0.59–1.37)  
 ≥80 1.34 (0.87–2.06)  1.24 (0.77–2.02)  
Female sex 1.05 (0.78–1.41) 0.76 0.99 (0.73–1.32) 0.92 
Race/ethnicity  <0.0001  0.003 
 Non-Hispanic White REF  REF  
 Non-Hispanic Asian 0.93 (0.62–1.39)  0.96 (0.65–1.41)  
 Non-Hispanic Black 2.52 (1.70–3.74)  2.10 (1.36–3.22)  
 Hispanic 1.34 (0.79–2.25)  1.24 (0.75–2.04)  
 Other/unknown 0.92 (0.54–1.56)  0.98 (0.57–1.67)  
A1C category, %  <0.0001  0.10 
 <6 1.86 (1.19–2.90)  1.56 (0.99, 2.46)  
 6–6.9 REF  REF  
 7–7.9 1.06 (0.72–1.57)  0.95 (0.65–1.41)  
 8–8.9 2.01 (1.31–3.07)  1.50 (0.97–2.32)  
 ≥9 1.83 (1.20–2.78)  1.28 (0.82–1.99)  
CKD (Stage 4–5)  <0.0001  <0.0001 
 No REF  REF  
 Yes 5.17 (3.62–7.39)  2.96 (2.01–4.35)  
Medication orders, pre-A1C  <0.0001  <0.0001 
 Any insulin 3.41 (1.69–6.86)  2.76 (1.37–5.56)  
 Any secretagogues, no insulin 1.53 (0.76–3.07)  1.41 (0.70–2.84)  
 Metformin only 0.38 (0.16–0.90)  0.39 (0.16–0.93)  
 Other glucose-lowering medication REF  REF  
Insurance  <0.0001  0.001 
 Private REF  REF  
 Medicare 2.73 (1.81–4.12)  2.38 (1.56–3.61)  
 Medicaid 2.39 (1.43–4.00)  1.93 (1.15–3.24)  
 Other/Unknown 3.05 (1.40–6.68)  2.84 (1.31–6.15)  

REF, reference.

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