. | Closed-loop (n = 12) . | Control (n = 12) . | P value . |
---|---|---|---|
Time spent at glucose level (%) | |||
3.9–10.0 mmol/L* | 72 (59–77) | 53 (46–59) | <0.001 |
>10.0 mmol/L | 26 (21–35) | 43 (38–52) | 0.005 |
<3.9 mmol/L | 2.9 (1.8–4.8) | 1.7 (0.9–5.1) | 0.87 |
<2.8 mmol/L | 0.2 (0.0–0.6) | 0.1 (0.0–0.6) | 0.67 |
AUCday <3.5 mmol/L (mmol/L × min)† | 6.4 (2.8–23.7) | 4.3 (1.8–13.6) | 0.77 |
Mean glucose (mmol/L) | 8.7 ± 1.1 | 10.1 ± 1.3 | 0.028 |
Within-day SD of glucose (mmol/L) | 3.5 (3.3–4.2) | 4.0 (3.6–4.6) | 0.21 |
CV of glucose within day (%) | 41 (40–45) | 39 (38–44) | 0.36 |
CV of glucose between days (%) | 17 (11–22) | 19 (17–25) | 0.80 |
Total daily dose (units/day) | 57.3 (45.6–65.2) | 56.6 (44.7–61.3) | 0.55 |
Total bolus (units/day) | 31.9 (21.2–41.0) | 38.3 (26.4–41.4) | 0.06 |
Total basal (units/day) | 24.3 (22.8–28.8) | 20.3 (19.1–22.1) | 0.001 |
CV of basal insulin (%) | 94 (91–103) | 16 (13–26) | <0.001 |
. | Closed-loop (n = 12) . | Control (n = 12) . | P value . |
---|---|---|---|
Time spent at glucose level (%) | |||
3.9–10.0 mmol/L* | 72 (59–77) | 53 (46–59) | <0.001 |
>10.0 mmol/L | 26 (21–35) | 43 (38–52) | 0.005 |
<3.9 mmol/L | 2.9 (1.8–4.8) | 1.7 (0.9–5.1) | 0.87 |
<2.8 mmol/L | 0.2 (0.0–0.6) | 0.1 (0.0–0.6) | 0.67 |
AUCday <3.5 mmol/L (mmol/L × min)† | 6.4 (2.8–23.7) | 4.3 (1.8–13.6) | 0.77 |
Mean glucose (mmol/L) | 8.7 ± 1.1 | 10.1 ± 1.3 | 0.028 |
Within-day SD of glucose (mmol/L) | 3.5 (3.3–4.2) | 4.0 (3.6–4.6) | 0.21 |
CV of glucose within day (%) | 41 (40–45) | 39 (38–44) | 0.36 |
CV of glucose between days (%) | 17 (11–22) | 19 (17–25) | 0.80 |
Total daily dose (units/day) | 57.3 (45.6–65.2) | 56.6 (44.7–61.3) | 0.55 |
Total bolus (units/day) | 31.9 (21.2–41.0) | 38.3 (26.4–41.4) | 0.06 |
Total basal (units/day) | 24.3 (22.8–28.8) | 20.3 (19.1–22.1) | 0.001 |
CV of basal insulin (%) | 94 (91–103) | 16 (13–26) | <0.001 |
Data are presented as the median (interquartile range) or mean ± SD, unless otherwise indicated.
*Primary end point.
†AUCday, glucose AUC <3.5 mmol/L/day.