Patient characteristics . | Placebo (N = 17) . | Sotagliflozin (N = 16) . |
---|---|---|
Age (years), median (range) | 34.0 (21, 57) | 45.5 (21, 55) |
Sex, n (%) | ||
Female | 9 (53) | 8 (50) |
Male | 8 (47) | 8 (50) |
Race, n (%) | ||
White/Caucasian | 14 (82) | 16 (100) |
Asian | 2 (12) | 0 |
Other | 1 (6) | 0 |
Weight (kg), median (range) | 72.7 (55.3, 104.6) | 74.2 (55.6, 107.9) |
BMI (kg/m2), mean (SD) | 26.2 (3.0) | 27.1 (3.1) |
Duration of diabetes (years), median (range) | 18.5 (4.7, 40.8) | 16.8 (3.4, 42.9) |
HbA1c (%), mean (SD) | 7.98 (0.51) | 7.94 (0.55) |
HbA1c (mmol/mol), mean (SD) | 62.83 (5.66) | 63.38 (6.04) |
FPG (mmol/L), mean (SD) | 8.89 (3.96) | 9.45 (3.45) |
Seated systolic BP (mmHg), mean (SD) | 119.8 (7.0) | 118.1 (9.2) |
Serum sodium (mmol/L), mean (SD) | 138.24 (3.75) | 137.63 (2.45) |
Serum creatinine (µmol/L), mean (SD) | 76.11 (9.86) | 76.94 (11.82) |
Serum BUN (mmol/L), mean (SD) | 4.68 (0.99) | 4.96 (1.02) |
Hematocrit, mean (SD) | 41.94 (4.87) | 41.63 (4.86) |
Insulin therapy, n (%) | ||
MDI | 5 (29) | 6 (38) |
CSII | 12 (71) | 10 (63) |
Total daily insulin (IU/kg), mean | 0.60 | 0.60 |
Daily insulin, ratio of bolus/total | 0.45 | 0.49 |
Patient characteristics . | Placebo (N = 17) . | Sotagliflozin (N = 16) . |
---|---|---|
Age (years), median (range) | 34.0 (21, 57) | 45.5 (21, 55) |
Sex, n (%) | ||
Female | 9 (53) | 8 (50) |
Male | 8 (47) | 8 (50) |
Race, n (%) | ||
White/Caucasian | 14 (82) | 16 (100) |
Asian | 2 (12) | 0 |
Other | 1 (6) | 0 |
Weight (kg), median (range) | 72.7 (55.3, 104.6) | 74.2 (55.6, 107.9) |
BMI (kg/m2), mean (SD) | 26.2 (3.0) | 27.1 (3.1) |
Duration of diabetes (years), median (range) | 18.5 (4.7, 40.8) | 16.8 (3.4, 42.9) |
HbA1c (%), mean (SD) | 7.98 (0.51) | 7.94 (0.55) |
HbA1c (mmol/mol), mean (SD) | 62.83 (5.66) | 63.38 (6.04) |
FPG (mmol/L), mean (SD) | 8.89 (3.96) | 9.45 (3.45) |
Seated systolic BP (mmHg), mean (SD) | 119.8 (7.0) | 118.1 (9.2) |
Serum sodium (mmol/L), mean (SD) | 138.24 (3.75) | 137.63 (2.45) |
Serum creatinine (µmol/L), mean (SD) | 76.11 (9.86) | 76.94 (11.82) |
Serum BUN (mmol/L), mean (SD) | 4.68 (0.99) | 4.96 (1.02) |
Hematocrit, mean (SD) | 41.94 (4.87) | 41.63 (4.86) |
Insulin therapy, n (%) | ||
MDI | 5 (29) | 6 (38) |
CSII | 12 (71) | 10 (63) |
Total daily insulin (IU/kg), mean | 0.60 | 0.60 |
Daily insulin, ratio of bolus/total | 0.45 | 0.49 |
BP, blood pressure.