. | HT . | Placebo . | Hormone vs. placebo therapy . | Diabetes vs. no diabetes . | Interaction P . | ||
---|---|---|---|---|---|---|---|
Diabetes (N = 274) . | No diabetes (N = 3,282) . | Diabetes (N = 264) . | No diabetes (N = 3,413) . | ||||
Through a maximum of 6 years of follow-up | |||||||
CEE-alone trial | 3.91 (2.46–6.21) 25 cases | 1.17 (0.84–1.63) 75 cases | 1.47 (0.79–2.73) 12 cases | 1.00 (Ref) 66 cases | 1.38 (1.02–1.86) P = 0.03 | 2.39 (1.66–3.44) P < 0.001 | 0.04 |
CEE+MPA trial | 2.31 (1.28–4.19) 13 cases | 1.20 (0.88–1.65) 95 cases | 2.44 (1.32–4.52) 2 cases | 1.00 (Ref) 70 cases | 1.17 (0.88–1.56) P = 0.29 | 2.13 (1.40–3.26) P < 0.001 | 0.57 |
Combined | 3.30 (2.30–4.73) 38 cases | 1.19 (0.94–1.49) 170 cases | 1.96 (1.27–3.03) 24 cases | 1.00 (Ref) 136 cases | 1.26 (1.02–1.55) P = 0.03 | 2.40 (1.82–3.15) P < 0.001 | 0.22 |
Through a maximum of 12 years of follow-up | |||||||
CEE-alone trial | 2.63 (1.77–3.91) 31 cases | 0.95 (0.74–1.23) 115 cases | 1.26 (0.77–2.08) 18 cases | 1.00 (Ref) 124 cases | 1.09 (0.86–1.37) P = 0.48 | 1.94 (1.42–2.64) P < 0.001 | 0.02 |
CEE+MPA trial | 2.10 (1.30–3.40) 19 cases | 1.07 (0.85–1.34) 156 cases | 2.05 (1.20–3.49) 15 cases | 1.00 (Ref) 142 cases | 1.06 (0.86–1.32) P = 0.58 | 2.01 (1.40–2.86) P < 0.001 | 0.92 |
Combined | 2.52 (1.86–3.41) 50 cases | 1.02 (0.86–1.20) 271 cases | 1.63 (1.13–2.34) 33 cases | 1.00 (Ref) 266 cases | 1.07 (0.92–1.26) P = 0.38 | 2.05 (1.63–2.59) P < 0.001 | 0.08 |
Through a maximum of 18 years of follow-up | |||||||
CEE-alone trial | 2.35 (1.66–3.33) 38 cases | 0.98 (0.80–1.19) 191 cases | 1.28 (0.86–1.92) 27 cases | 1.00 (Ref) 212 cases | 1.07 (0.89–1.28) P = 0.49 | 1.77 (1.36–2.31) P < 0.001 | 0.02 |
CEE+MPA trial | 1.86 (1.24–2.78) 26 cases | 1.04 (0.88–1.23) 283 cases | 1.73 (1.09–2.76) 19 cases | 1.00 (Ref) 281 cases | 1.05 (0.89–1.23) P = 0.58 | 1.76 (1.30–2.39) P < 0.001 | 0.93 |
Combined | 2.20 (1.70–2.87) 64 cases | 1.02 (0.90–1.16) 474 cases | 1.50 (1.10–2.04) 46 cases | 1.00 (Ref) 493 cases | 1.06 (0.94–1.20) P = 0.34 | 1.83 (1.50–2.23) P < 0.001 | 0.08 |
. | HT . | Placebo . | Hormone vs. placebo therapy . | Diabetes vs. no diabetes . | Interaction P . | ||
---|---|---|---|---|---|---|---|
Diabetes (N = 274) . | No diabetes (N = 3,282) . | Diabetes (N = 264) . | No diabetes (N = 3,413) . | ||||
Through a maximum of 6 years of follow-up | |||||||
CEE-alone trial | 3.91 (2.46–6.21) 25 cases | 1.17 (0.84–1.63) 75 cases | 1.47 (0.79–2.73) 12 cases | 1.00 (Ref) 66 cases | 1.38 (1.02–1.86) P = 0.03 | 2.39 (1.66–3.44) P < 0.001 | 0.04 |
CEE+MPA trial | 2.31 (1.28–4.19) 13 cases | 1.20 (0.88–1.65) 95 cases | 2.44 (1.32–4.52) 2 cases | 1.00 (Ref) 70 cases | 1.17 (0.88–1.56) P = 0.29 | 2.13 (1.40–3.26) P < 0.001 | 0.57 |
Combined | 3.30 (2.30–4.73) 38 cases | 1.19 (0.94–1.49) 170 cases | 1.96 (1.27–3.03) 24 cases | 1.00 (Ref) 136 cases | 1.26 (1.02–1.55) P = 0.03 | 2.40 (1.82–3.15) P < 0.001 | 0.22 |
Through a maximum of 12 years of follow-up | |||||||
CEE-alone trial | 2.63 (1.77–3.91) 31 cases | 0.95 (0.74–1.23) 115 cases | 1.26 (0.77–2.08) 18 cases | 1.00 (Ref) 124 cases | 1.09 (0.86–1.37) P = 0.48 | 1.94 (1.42–2.64) P < 0.001 | 0.02 |
CEE+MPA trial | 2.10 (1.30–3.40) 19 cases | 1.07 (0.85–1.34) 156 cases | 2.05 (1.20–3.49) 15 cases | 1.00 (Ref) 142 cases | 1.06 (0.86–1.32) P = 0.58 | 2.01 (1.40–2.86) P < 0.001 | 0.92 |
Combined | 2.52 (1.86–3.41) 50 cases | 1.02 (0.86–1.20) 271 cases | 1.63 (1.13–2.34) 33 cases | 1.00 (Ref) 266 cases | 1.07 (0.92–1.26) P = 0.38 | 2.05 (1.63–2.59) P < 0.001 | 0.08 |
Through a maximum of 18 years of follow-up | |||||||
CEE-alone trial | 2.35 (1.66–3.33) 38 cases | 0.98 (0.80–1.19) 191 cases | 1.28 (0.86–1.92) 27 cases | 1.00 (Ref) 212 cases | 1.07 (0.89–1.28) P = 0.49 | 1.77 (1.36–2.31) P < 0.001 | 0.02 |
CEE+MPA trial | 1.86 (1.24–2.78) 26 cases | 1.04 (0.88–1.23) 283 cases | 1.73 (1.09–2.76) 19 cases | 1.00 (Ref) 281 cases | 1.05 (0.89–1.23) P = 0.58 | 1.76 (1.30–2.39) P < 0.001 | 0.93 |
Combined | 2.20 (1.70–2.87) 64 cases | 1.02 (0.90–1.16) 474 cases | 1.50 (1.10–2.04) 46 cases | 1.00 (Ref) 493 cases | 1.06 (0.94–1.20) P = 0.34 | 1.83 (1.50–2.23) P < 0.001 | 0.08 |