AAFs (95% CIs) of inadequately controlled risk factors for major CV events and all-cause mortality among adults with diabetes with and without baseline CVD
| Inadequately controlled factors . | No CVD (n = 593,167) . | CVD (n = 266,450) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MI/ACS . | Stroke . | HF . | All CV . | All-cause mortality . | MI/ACS . | Stroke . | HF . | All CV . | All-cause mortality . | |
| Current smoking | 4.5% (4.1–4.9) | 3.4% (3.0–3.8) | 3.6% (3.2–4.0) | 3.8% (3.5–4.0) | 5.1% (4.8–5.5) | 2.5% (2.3–2.8) | 1.8% (1.6–2.0) | 1.1% (1.0–1.2) | 1.8% (1.7–2.0) | 2.6% (2.4–2.7) |
| Systolic/diastolic BP ≥140/90 mmHg | 5.4% (4.9–5.8) | 11.6% (10.9–12.4) | 12.4% (11.6–13.3) | 9.4% (9.0–9.8) | 1.5% (1.4–1.7) | 4.1% (3.8–4.4) | 7.0% (6.6–7.5) | 1.0% (0.8–1.1) | 3.5% (3.4–3.7) | — |
| LDL-C ≥100 mg/dL | 19.6% (18.7–20.5) | 13.7% (12.9–14.5) | 4.4% (3.9–4.9) | 12.6% (12.2–13.1) | — | 5.1% (4.8–5.5) | 5.9% (5.5–6.3) | — | 2.5% (2.4–2.7) | — |
| A1C ≥7% (≥53 mmol/mol) | 6.7% (6.2–7.2) | 6.7% (6.2–7.3) | 9.8% (9.1–10.6) | 7.4% (7.0–7.7) | — | 3.0% (2.7–3.2) | 3.6% (3.3–3.9) | 2.6% (2.4–2.8) | 3.0% (2.8–3.2) | — |
| Inadequately controlled factors . | No CVD (n = 593,167) . | CVD (n = 266,450) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MI/ACS . | Stroke . | HF . | All CV . | All-cause mortality . | MI/ACS . | Stroke . | HF . | All CV . | All-cause mortality . | |
| Current smoking | 4.5% (4.1–4.9) | 3.4% (3.0–3.8) | 3.6% (3.2–4.0) | 3.8% (3.5–4.0) | 5.1% (4.8–5.5) | 2.5% (2.3–2.8) | 1.8% (1.6–2.0) | 1.1% (1.0–1.2) | 1.8% (1.7–2.0) | 2.6% (2.4–2.7) |
| Systolic/diastolic BP ≥140/90 mmHg | 5.4% (4.9–5.8) | 11.6% (10.9–12.4) | 12.4% (11.6–13.3) | 9.4% (9.0–9.8) | 1.5% (1.4–1.7) | 4.1% (3.8–4.4) | 7.0% (6.6–7.5) | 1.0% (0.8–1.1) | 3.5% (3.4–3.7) | — |
| LDL-C ≥100 mg/dL | 19.6% (18.7–20.5) | 13.7% (12.9–14.5) | 4.4% (3.9–4.9) | 12.6% (12.2–13.1) | — | 5.1% (4.8–5.5) | 5.9% (5.5–6.3) | — | 2.5% (2.4–2.7) | — |
| A1C ≥7% (≥53 mmol/mol) | 6.7% (6.2–7.2) | 6.7% (6.2–7.3) | 9.8% (9.1–10.6) | 7.4% (7.0–7.7) | — | 3.0% (2.7–3.2) | 3.6% (3.3–3.9) | 2.6% (2.4–2.8) | 3.0% (2.8–3.2) | — |
Estimates adjusted for age, sex, race/ethnicity, diabetes medication, statins, BP medication, CKD at baseline, incident diabetes at baseline, HDL-C ≤40 mg/dL (men)/50 mg/dL (women), elevated LDL-C (≥100 mg/dL), elevated A1C (≥8% [64 mmol/mol]), elevated systolic/diastolic BP (≥140/90 mmHg). —, factors not associated with an increased number of CV events or mortality.