Inadequately controlled factors . | No CVD (n = 593,167) . | CVD (n = 266,450) . | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
MI/ACS . | Stroke . | HF . | All CV . | All-cause mortality . | MI/ACS . | Stroke . | HF . | All CV . | All-cause mortality . | |
Events, n | 10,511 | 9,377 | 7,768 | 25,189 | 20,282 | 18,458 | 16,311 | 25,308 | 51,129 | 46,610 |
Current smoking | 1.64 (1.55–1.74) | 1.53 (1.43–1.64) | 1.53 (1.42–1.64) | 1.53 (1.47–1.61) | 1.62 (1.55–1.69) | 1.39 (1.32–1.46) | 1.29 (1.22–1.36) | 1.12 (1.07–1.18) | 1.30 (1.25–1.36) | 1.35 (1.31–1.40) |
Systolic/diastolic BP, mmHg | ||||||||||
≥140/90 | 1.18 (1.15–1.22) | 1.37 (1.33–1.41) | 1.37 (1.33–1.42) | 1.31 (1.28–1.34) | 1.06 (1.04–1.09) | 1.13 (1.11–1.16) | 1.20 (1.18–1.23) | 1.05 (1.03–1.08) | 1.12 (1.10–1.14) | 0.99 (0.98–1.01) |
130–139/80–89 | 0.91 (0.89–0.94) | 0.92 (0.90–0.95) | 0.83 (0.80–0.86) | 0.89 (0.87–0.91) | 0.85 (0.83–0.87) | 0.91 (0.89–0.93) | 0.95 (0.93–0.97) | 0.85 (0.83–0.86) | 0.89 (0.87–0.90) | 0.85 (0.84–0.86) |
<130/80 (reference) | — | — | — | — | — | — | — | — | — | — |
LDL-C, mg/dL | ||||||||||
≥130 | 1.51 (1.46–1.56) | 1.31 (1.27–1.36) | 1.10 (1.06–1.15) | 1.30 (1.27–1.33) | 0.98 (0.98–1.00) | 1.22 (1.18–1.25) | 1.18 (1.14–1.22) | 1.02 (0.99–1.05) | 1.11 (1.09–1.14) | 1.02 (0.99–1.04) |
100–129 | 1.06 (1.03–1.10) | 1.02 (0.99–1.06) | 0.94 (0.90–0.97) | 0.98 (0.96–1.01) | 0.91 (0.89–0.93) | 0.99 (0.96–1.01) | 1.01 (0.98–1.04) | 0.92 (0.90–0.94) | 0.96 (0.94–0.98) | 0.92 (0.91–0.94) |
70–99 | 0.83 (0.80–0.85) | 0.88 (0.85–0.91) | 0.99 (0.87–0.94) | 0.86 (0.84–0.88) | 0.96 (0.94–0.98) | 0.91 (0.89–0.93) | 0.92 (0.90–0.94) | 0.96 (0.94–0.97) | 0.92 (0.91–0.94) | 0.93 (0.92–0.95) |
<70 (reference) | — | — | — | — | — | — | — | — | — | — |
A1C, % (mmol/mol) | ||||||||||
≥9 (≥75) | 1.18 (1.14–1.23) | 1.29 (1.23–1.34) | 1.37 (1.31–1.44) | 1.25 (1.22–1.29) | 1.01 (0.98–1.05) | 1.14 (1.10–1.18) | 1.22 (1.17–1.27) | 1.16 (1.13–1.20) | 1.17 (1.14–1.20) | 1.01 (0.98–1.03) |
8–8.9 (64–74) | 1.09 (1.04–1.15) | 0.98 (0.92–1.03) | 1.01 (0.96–1.07) | 1.03 (0.99–1.07) | 0.90 (0.87–0.94) | 1.01 (0.98–1.05) | 0.99 (0.95–1.03) | 0.98 (0.95–1.01) | 1.0 (0.97–1.03) | 0.89 (0.87–0.91) |
7–7.9 (53–63) | 0.98 (0.94–1.02) | 0.94 (0.91–0.98) | 0.88 (0.84–0.92) | 0.93 (0.91–0.96) | 0.94 (0.91–0.96) | 0.98 (0.95–1.01) | 0.92 (0.89–0.95) | 0.94 (0.92–0.97) | 0.94 (0.92–0.96) | 0.91 (0.89–0.93) |
6.5–6.9 (48–52) (reference) | — | — | — | — | — | — | — | — | — | — |
<6.5 (<48) | 0.90 (0.86–0.94) | 0.90 (0.87–0.95) | 0.87 (0.83–0.92) | 0.89 (0.87–0.92) | 0.96 (0.94–0.99) | 0.92 (0.89–0.95) | 0.95 (0.92–0.98) | 0.92 (0.90–0.94) | 0.92 (0.90–0.94) | 0.98 (0.96–1.0) |
Inadequately controlled factors . | No CVD (n = 593,167) . | CVD (n = 266,450) . | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
MI/ACS . | Stroke . | HF . | All CV . | All-cause mortality . | MI/ACS . | Stroke . | HF . | All CV . | All-cause mortality . | |
Events, n | 10,511 | 9,377 | 7,768 | 25,189 | 20,282 | 18,458 | 16,311 | 25,308 | 51,129 | 46,610 |
Current smoking | 1.64 (1.55–1.74) | 1.53 (1.43–1.64) | 1.53 (1.42–1.64) | 1.53 (1.47–1.61) | 1.62 (1.55–1.69) | 1.39 (1.32–1.46) | 1.29 (1.22–1.36) | 1.12 (1.07–1.18) | 1.30 (1.25–1.36) | 1.35 (1.31–1.40) |
Systolic/diastolic BP, mmHg | ||||||||||
≥140/90 | 1.18 (1.15–1.22) | 1.37 (1.33–1.41) | 1.37 (1.33–1.42) | 1.31 (1.28–1.34) | 1.06 (1.04–1.09) | 1.13 (1.11–1.16) | 1.20 (1.18–1.23) | 1.05 (1.03–1.08) | 1.12 (1.10–1.14) | 0.99 (0.98–1.01) |
130–139/80–89 | 0.91 (0.89–0.94) | 0.92 (0.90–0.95) | 0.83 (0.80–0.86) | 0.89 (0.87–0.91) | 0.85 (0.83–0.87) | 0.91 (0.89–0.93) | 0.95 (0.93–0.97) | 0.85 (0.83–0.86) | 0.89 (0.87–0.90) | 0.85 (0.84–0.86) |
<130/80 (reference) | — | — | — | — | — | — | — | — | — | — |
LDL-C, mg/dL | ||||||||||
≥130 | 1.51 (1.46–1.56) | 1.31 (1.27–1.36) | 1.10 (1.06–1.15) | 1.30 (1.27–1.33) | 0.98 (0.98–1.00) | 1.22 (1.18–1.25) | 1.18 (1.14–1.22) | 1.02 (0.99–1.05) | 1.11 (1.09–1.14) | 1.02 (0.99–1.04) |
100–129 | 1.06 (1.03–1.10) | 1.02 (0.99–1.06) | 0.94 (0.90–0.97) | 0.98 (0.96–1.01) | 0.91 (0.89–0.93) | 0.99 (0.96–1.01) | 1.01 (0.98–1.04) | 0.92 (0.90–0.94) | 0.96 (0.94–0.98) | 0.92 (0.91–0.94) |
70–99 | 0.83 (0.80–0.85) | 0.88 (0.85–0.91) | 0.99 (0.87–0.94) | 0.86 (0.84–0.88) | 0.96 (0.94–0.98) | 0.91 (0.89–0.93) | 0.92 (0.90–0.94) | 0.96 (0.94–0.97) | 0.92 (0.91–0.94) | 0.93 (0.92–0.95) |
<70 (reference) | — | — | — | — | — | — | — | — | — | — |
A1C, % (mmol/mol) | ||||||||||
≥9 (≥75) | 1.18 (1.14–1.23) | 1.29 (1.23–1.34) | 1.37 (1.31–1.44) | 1.25 (1.22–1.29) | 1.01 (0.98–1.05) | 1.14 (1.10–1.18) | 1.22 (1.17–1.27) | 1.16 (1.13–1.20) | 1.17 (1.14–1.20) | 1.01 (0.98–1.03) |
8–8.9 (64–74) | 1.09 (1.04–1.15) | 0.98 (0.92–1.03) | 1.01 (0.96–1.07) | 1.03 (0.99–1.07) | 0.90 (0.87–0.94) | 1.01 (0.98–1.05) | 0.99 (0.95–1.03) | 0.98 (0.95–1.01) | 1.0 (0.97–1.03) | 0.89 (0.87–0.91) |
7–7.9 (53–63) | 0.98 (0.94–1.02) | 0.94 (0.91–0.98) | 0.88 (0.84–0.92) | 0.93 (0.91–0.96) | 0.94 (0.91–0.96) | 0.98 (0.95–1.01) | 0.92 (0.89–0.95) | 0.94 (0.92–0.97) | 0.94 (0.92–0.96) | 0.91 (0.89–0.93) |
6.5–6.9 (48–52) (reference) | — | — | — | — | — | — | — | — | — | — |
<6.5 (<48) | 0.90 (0.86–0.94) | 0.90 (0.87–0.95) | 0.87 (0.83–0.92) | 0.89 (0.87–0.92) | 0.96 (0.94–0.99) | 0.92 (0.89–0.95) | 0.95 (0.92–0.98) | 0.92 (0.90–0.94) | 0.92 (0.90–0.94) | 0.98 (0.96–1.0) |
Estimates adjusted for age, sex, race/ethnicity, diabetes medication, statins, BP medication, CKD at baseline, incident diabetes at baseline, low HDL-C (≤40 mg/dL [men]/50 mg/dL [women]), and all other inadequately controlled factors as described in the table.