Adjusted odds of a low HRQOL score (≤25th percentile) by urologic complication status in men and women at EDIC year 17
| HRQOL measure . | Urologic complications in men . | Urologic complications in women . | ||||
|---|---|---|---|---|---|---|
| ED only (n = 115) vs. . | LUTS only (n = 79) vs. . | ED and LUTS (n = 79) vs. . | FSD only (n = 71) vs. . | UI/LUTS only (n = 147) vs. . | FSD and UI/LUTS (n = 75) vs. . | |
| No ED or LUTS (n = 361) . | No FSD or UI/LUTS (n = 259) . | |||||
| Total DQOL score | 3.2 (1.9–5.4) | 2.6 (1.5–4.8) | 7.2 (4.0–13.2) | 3.0 (1.6–5.9) | 3.1 (1.8–5.3) | 4.6 (2.5–8.7) |
| EQ-5D preference weighted mean | 1.9 (1.2–3.0) | 0.9 (0.5–1.6) | 4.0 (2.2–7.2) | 2.8 (1.5–5.3) | 3.4 (2.1–5.7) | 5.3 (2.9–10.0) |
| SF-36 subscales | ||||||
| Physical Function | 2.9 (1.8–4.9) | 2.0 (1.1–3.5) | 7.7 (4.3–13.9) | 2.1 (1.1–4.1) | 2.4 (1.4–4.0) | 3.7 (2.0–6.8) |
| Social Function | 2.9 (1.8–4.7) | 2.3 (1.4–4.0) | 4.3 (2.4–7.4) | 2.8 (1.6–5.0) | 2.7 (1.7–4.2) | 2.2 (1.3–4.0) |
| Role Function Physical | 2.5 (1.5–4.1) | 2.9 (1.6–5.1) | 4.6 (2.6–8.2) | 2.1 (1.1–4.0) | 2.7 (1.6–4.4) | 2.9 (1.6–5.4) |
| Role Function Emotional | 2.1 (0.9–4.8) | 2.5 (1.0–6.2) | 2.3 (0.9–6.0) | 2.1 (1.2–3.9) | 2.4 (1.5–3.8) | 1.8 (1.0–3.3) |
| Mental Health | 3.1 (1.8–5.1) | 2.2 (1.2–4.0) | 4.0 (2.2–7.2) | 3.1 (1.7–5.8) | 2.6 (1.6–4.3) | 2.1 (1.1–4.1) |
| Vitality | 2.5 (1.5–4.1) | 2.5 (1.4–4.4) | 5.0 (2.8–8.9) | 4.1 (2.2–7.4) | 2.8 (1.8–4.6) | 4.0 (2.2–7.2) |
| Bodily Pain | 1.7 (1.1–2.7) | 2.0 (1.2–3.3) | 2.5 (1.5–4.3) | 2.2 (1.3–3.9) | 1.8 (1.2–2.7) | 2.9 (1.6–5.1) |
| General Health Perception | 4.0 (2.4–6.7) | 2.1 (1.1–3.9) | 6.5 (3.6–11.7) | 3.9 (2.0–7.4) | 2.5 (1.5–4.2) | 3.5 (1.9–6.7) |
| SCL-90 GSI T score* | 2.7 (1.2–6.0) | 3.1 (1.3–7.4) | 8.9 (3.9–20.0) | 4.4 (2.0–10.1) | 3.9 (1.9–7.8) | 5.7 (2.5–12.6) |
| HRQOL measure . | Urologic complications in men . | Urologic complications in women . | ||||
|---|---|---|---|---|---|---|
| ED only (n = 115) vs. . | LUTS only (n = 79) vs. . | ED and LUTS (n = 79) vs. . | FSD only (n = 71) vs. . | UI/LUTS only (n = 147) vs. . | FSD and UI/LUTS (n = 75) vs. . | |
| No ED or LUTS (n = 361) . | No FSD or UI/LUTS (n = 259) . | |||||
| Total DQOL score | 3.2 (1.9–5.4) | 2.6 (1.5–4.8) | 7.2 (4.0–13.2) | 3.0 (1.6–5.9) | 3.1 (1.8–5.3) | 4.6 (2.5–8.7) |
| EQ-5D preference weighted mean | 1.9 (1.2–3.0) | 0.9 (0.5–1.6) | 4.0 (2.2–7.2) | 2.8 (1.5–5.3) | 3.4 (2.1–5.7) | 5.3 (2.9–10.0) |
| SF-36 subscales | ||||||
| Physical Function | 2.9 (1.8–4.9) | 2.0 (1.1–3.5) | 7.7 (4.3–13.9) | 2.1 (1.1–4.1) | 2.4 (1.4–4.0) | 3.7 (2.0–6.8) |
| Social Function | 2.9 (1.8–4.7) | 2.3 (1.4–4.0) | 4.3 (2.4–7.4) | 2.8 (1.6–5.0) | 2.7 (1.7–4.2) | 2.2 (1.3–4.0) |
| Role Function Physical | 2.5 (1.5–4.1) | 2.9 (1.6–5.1) | 4.6 (2.6–8.2) | 2.1 (1.1–4.0) | 2.7 (1.6–4.4) | 2.9 (1.6–5.4) |
| Role Function Emotional | 2.1 (0.9–4.8) | 2.5 (1.0–6.2) | 2.3 (0.9–6.0) | 2.1 (1.2–3.9) | 2.4 (1.5–3.8) | 1.8 (1.0–3.3) |
| Mental Health | 3.1 (1.8–5.1) | 2.2 (1.2–4.0) | 4.0 (2.2–7.2) | 3.1 (1.7–5.8) | 2.6 (1.6–4.3) | 2.1 (1.1–4.1) |
| Vitality | 2.5 (1.5–4.1) | 2.5 (1.4–4.4) | 5.0 (2.8–8.9) | 4.1 (2.2–7.4) | 2.8 (1.8–4.6) | 4.0 (2.2–7.2) |
| Bodily Pain | 1.7 (1.1–2.7) | 2.0 (1.2–3.3) | 2.5 (1.5–4.3) | 2.2 (1.3–3.9) | 1.8 (1.2–2.7) | 2.9 (1.6–5.1) |
| General Health Perception | 4.0 (2.4–6.7) | 2.1 (1.1–3.9) | 6.5 (3.6–11.7) | 3.9 (2.0–7.4) | 2.5 (1.5–4.2) | 3.5 (1.9–6.7) |
| SCL-90 GSI T score* | 2.7 (1.2–6.0) | 3.1 (1.3–7.4) | 8.9 (3.9–20.0) | 4.4 (2.0–10.1) | 3.9 (1.9–7.8) | 5.7 (2.5–12.6) |
Each row represents one multivariate logistic regression model. Data are odds ratios (95% CI) adjusted for treatment group, EDIC year 17 age and education, and DCCT/EDIC time-weighted HbA1c. Sample sizes vary based on availability of HRQOL data.
*SCL-90 scores are converted to standard T scores (ranging from 30 to 80) by referring to the appropriate population-based norm tables. T-scores have a mean of 50, SD of 10, and normal range from 40 to 60. A possible mental disorder is defined as a GSI T score ≥63.