Odds ratio (95% CI) for the percentage of Look AHEAD cohort achieving clinically meaningful changes in CVD risk factors
| Clinical criteria . | Gained >2% . | Stable Gained ≤2 or lost <2% . | Lost ≥2 to <5% . | Lost ≥5 to <10% . | Lost ≥10 to <15% . | Lost ≥15% . |
|---|---|---|---|---|---|---|
| 5 mmHg decrease in SBP | 0.86 (0.70–1.06) | 1.0 | 1.24 (1.02–1.50) | 1.56 (1.27–1.91) | 2.29 (1.79–2.93) | 2.65 (2.00–3.50) |
| 5 mmHg decrease in DBP | 1.03 (0.83–1.28) | 1.0 | 1.05 (0.86–1.28) | 1.48 (1.20–1.82) | 1.60 (1.25–2.06) | 2.39 (1.81–3.16) |
| 20 mg/dL decrease in glucose | 1.13 (0.87–1.46) | 1.0 | 1.75 (1.40–2.19) | 3.24 (2.57–4.09) | 4.07 (3.09–5.36) | 7.92 (5.78–10.85) |
| 0.05% decrease in HbA1c | 1.17 (0.91–1.50) | 1.0 | 1.80 (1.44–2.24) | 3.52 (2.81–4.40) | 5.44 (4.15–7.13) | 10.02 (7.31–13.73) |
| 5 mg/dL increase in HDL | 0.88 (0.71–1.11) | 1.0 | 1.13 (0.93–1.39) | 1.69 (1.37–2.07) | 2.30 (1.80–2.93) | 4.34 (3.30–5.72) |
| 5 mg/dL increase in HDL (not on medications) | 0.79 (0.54–1.15) | 1.0 | 0.99 (0.71–1.39) | 1.52 (1.08–2.15) | 2.54 (1.68–3.82) | 5.27 (3.36–8.27) |
| 10 mg/dL decrease in LDL | 1.17 (0.95–1.45) | 1.0 | 1.05 (0.86–1.29) | 1.34 (1.09–1.64) | 1.26 (0.98–1.62) | 1.34 (1.02–1.78) |
| 10 mg/dL decrease in LDL (not on medications) | 1.39 (0.97–1.99) | 1.0 | 0.97 (0.69–1.36) | 1.41 (1.00–2.00) | 1.28 (0.83–1.96) | 1.52 (0.96–2.41) |
| 40 mg/dL decrease in triglycerides | 0.80 (0.60–1.06) | 1.0 | 1.46 (1.14–1.87) | 2.20 (1.71–2.83) | 3.99 (2.97–5.35) | 7.18 (5.19–9.93) |
| Clinical criteria . | Gained >2% . | Stable Gained ≤2 or lost <2% . | Lost ≥2 to <5% . | Lost ≥5 to <10% . | Lost ≥10 to <15% . | Lost ≥15% . |
|---|---|---|---|---|---|---|
| 5 mmHg decrease in SBP | 0.86 (0.70–1.06) | 1.0 | 1.24 (1.02–1.50) | 1.56 (1.27–1.91) | 2.29 (1.79–2.93) | 2.65 (2.00–3.50) |
| 5 mmHg decrease in DBP | 1.03 (0.83–1.28) | 1.0 | 1.05 (0.86–1.28) | 1.48 (1.20–1.82) | 1.60 (1.25–2.06) | 2.39 (1.81–3.16) |
| 20 mg/dL decrease in glucose | 1.13 (0.87–1.46) | 1.0 | 1.75 (1.40–2.19) | 3.24 (2.57–4.09) | 4.07 (3.09–5.36) | 7.92 (5.78–10.85) |
| 0.05% decrease in HbA1c | 1.17 (0.91–1.50) | 1.0 | 1.80 (1.44–2.24) | 3.52 (2.81–4.40) | 5.44 (4.15–7.13) | 10.02 (7.31–13.73) |
| 5 mg/dL increase in HDL | 0.88 (0.71–1.11) | 1.0 | 1.13 (0.93–1.39) | 1.69 (1.37–2.07) | 2.30 (1.80–2.93) | 4.34 (3.30–5.72) |
| 5 mg/dL increase in HDL (not on medications) | 0.79 (0.54–1.15) | 1.0 | 0.99 (0.71–1.39) | 1.52 (1.08–2.15) | 2.54 (1.68–3.82) | 5.27 (3.36–8.27) |
| 10 mg/dL decrease in LDL | 1.17 (0.95–1.45) | 1.0 | 1.05 (0.86–1.29) | 1.34 (1.09–1.64) | 1.26 (0.98–1.62) | 1.34 (1.02–1.78) |
| 10 mg/dL decrease in LDL (not on medications) | 1.39 (0.97–1.99) | 1.0 | 0.97 (0.69–1.36) | 1.41 (1.00–2.00) | 1.28 (0.83–1.96) | 1.52 (0.96–2.41) |
| 40 mg/dL decrease in triglycerides | 0.80 (0.60–1.06) | 1.0 | 1.46 (1.14–1.87) | 2.20 (1.71–2.83) | 3.99 (2.97–5.35) | 7.18 (5.19–9.93) |
Significant odds ratios are shown in boldface.