. | Type 1 diabetes . | High GADA titer autoimmune diabetes . | Low GADA titer autoimmune diabetes . | Type 2 diabetes . | Control . |
---|---|---|---|---|---|
n | 558 | 123 | 127 | 450 | 545 |
Genotypes* | |||||
C1858C | 448 (80.3) | 98 (79.7) | 120 (94.5) | 424 (94.2) | 496 (91.1) |
C1858T | 105 (18.8) | 24 (19.5) | 7 (5.5) | 25 (5.6) | 47 (8.6) |
T1858T | 5 (0.9) | 1 (0.8) | 0 (0) | 1 (0.2) | 2 (0.4) |
Alleles† | |||||
C | 1001 (89.6) | 220 (89.5) | 247 (97.3) | 873 (97) | 1039 (95.4) |
T | 115 (10.4) | 26 (10.5) | 7 (2.7) | 27 (3) | 51 (4.6) |
Phenotypes‡ | |||||
CT/TT genotypes | 110 (19.7) | 25 (20.3) | 7 (5.5) | 26 (5.8) | 49 (9) |
CC genotype | 448 (80.3) | 98 (79.7) | 120 (94.5) | 424 (94.2) | 496 (91) |
. | Type 1 diabetes . | High GADA titer autoimmune diabetes . | Low GADA titer autoimmune diabetes . | Type 2 diabetes . | Control . |
---|---|---|---|---|---|
n | 558 | 123 | 127 | 450 | 545 |
Genotypes* | |||||
C1858C | 448 (80.3) | 98 (79.7) | 120 (94.5) | 424 (94.2) | 496 (91.1) |
C1858T | 105 (18.8) | 24 (19.5) | 7 (5.5) | 25 (5.6) | 47 (8.6) |
T1858T | 5 (0.9) | 1 (0.8) | 0 (0) | 1 (0.2) | 2 (0.4) |
Alleles† | |||||
C | 1001 (89.6) | 220 (89.5) | 247 (97.3) | 873 (97) | 1039 (95.4) |
T | 115 (10.4) | 26 (10.5) | 7 (2.7) | 27 (3) | 51 (4.6) |
Phenotypes‡ | |||||
CT/TT genotypes | 110 (19.7) | 25 (20.3) | 7 (5.5) | 26 (5.8) | 49 (9) |
CC genotype | 448 (80.3) | 98 (79.7) | 120 (94.5) | 424 (94.2) | 496 (91) |
Data are n (%).
χ2 3 × 2 high GADA titer vs. low GADA titer, type 2 diabetic, and control subjects, P ≤ 0.008 after Bonferroni correction. Type 1 diabetic vs. low GADA titer, type 2 diabetic, and control subjects, P ≤ 0.002 after Bonferroni correction.
χ2 2 × 2 high GADA titer vs. low GADA titer, type 2 diabetic, and control subjects, P ≤ 0.003 after Bonferroni correction. Type 1 diabetic vs. low GADA titer, type 2 diabetic, and control subjects, P < 0.0001 after Bonferroni correction.
χ2 2 × 2 high GADA titer vs. low GADA titer and type 2 diabetic and control subjects (OR 2.6 [95% CI 1.5–4.4]), P ≤ 0.002 after Bonferroni correction. Type 1 diabetic vs. low GADA titer, type 2 diabetic, and control subjects, P < 0.0001 after Bonferroni correction.