Model . | Independent variables . | OR (95% CI) . | P value
. |
---|---|---|---|

Independence | Carrier state (Y/N) for AKT2 risk haplotype^{*} | 2.10 (1.2–3.7) | 0.010 |

Carrier state (Y/N) for GSK3B risk haplotype^{*} | 1.80 (1.0–3.1) | 0.036 | |

Additive | Number of AKT2 or GSK3B risk haplotypes^{†} | 1.58 (1.1–2.2) | 0.010 |

Combined | Carrier state (Y/N) for both risk haplotypes in AKT2 and GSK3B^{‡} | 3.11 (1.4–6.9) | 0.0050 |

Model . | Independent variables . | OR (95% CI) . | P value
. |
---|---|---|---|

Independence | Carrier state (Y/N) for AKT2 risk haplotype^{*} | 2.10 (1.2–3.7) | 0.010 |

Carrier state (Y/N) for GSK3B risk haplotype^{*} | 1.80 (1.0–3.1) | 0.036 | |

Additive | Number of AKT2 or GSK3B risk haplotypes^{†} | 1.58 (1.1–2.2) | 0.010 |

Combined | Carrier state (Y/N) for both risk haplotypes in AKT2 and GSK3B^{‡} | 3.11 (1.4–6.9) | 0.0050 |

PCOS diagnosis was the dependent variable in all models. Each analysis also included age and BMI as independent variables.

*

Carriers are homozygous or heterozygous for risk haplotype (T-G-C-T in *AKT2* and C-A-C-C-G-G-A-G-G in *GSK3B*).

†

Number of risk haplotypes per individual is 0–4.

‡

Compares subjects who are carriers of at least one *AKT2* risk haplotype and at least one *GSK3B* risk haplotype to all other subjects.

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