Parameter . | LosartanRS . | LosartanLS . | Δ LosartanLS − Δ losartanRS . | P . | ||||
---|---|---|---|---|---|---|---|---|
Week 2 . | Week 4 . | Δ Week 4–2 . | Week 2 . | Week 4 . | ΔWeek 4–2 . | Δ . | ||
Blood pressure (mmHg) | ||||||||
24-h | ||||||||
Systolic | 139.6 ± 3.9 | 139.6 ± 4.8 | 0 ± 2.1 | 141.4 ± 4.0 | 131.7 ± 3.5 | −9.7 ± 2.7 | −9.7 (−17.2 to −2.2) | 0.002 |
Diastolic | 77.8 ± 1.5 | 78.2 ± 1.8 | 0.4 ± 0.9 | 78.9 ± 1.2 | 73.8 ± 1.8 | −5.1 ± 1.4 | −5.5 (−8.4 to −2.6) | 0.002 |
Mean arterial pressure | 99.3 ± 1.9 | 98.9 ± 2.4 | −0.4 ± 1.5 | 100.6 ± 1.8 | 92.9 ± 1.9 | −7.7 ± 1.7 | −7.3 (−11.3 to −3.3) | 0.003 |
Awake | ||||||||
Systolic | 142.5 ± 4 | 142.1 ± 4.9 | −0.4 ± 2.2 | 143.5 ± 4.5 | 133.6 ± 4.0 | −9.9 ± 3.2 | −9.5 (−18.4 to −0.6) | 0.039 |
Diastolic | 80.2 ± 1.6 | 80.1 ± 1.8 | −0.1 ± 0.8 | 80.7 ± 1.4 | 75.3 ± 2.0 | −5.4 ± 1.8 | −5.3 (−9.3 to −1.3) | 0.015 |
Mean arterial pressure | 101.8 ± 2.1 | 100.5 ± 2.3 | −1.3 ± 1.4 | 101.1 ± 2.7 | 94.1 ± 2.4 | −7.0 ± 2.6 | −5.7 (−11.3 to −0.1) | 0.048 |
Sleep | ||||||||
Systolic | 129.9 ± 3.4 | 129.6 ± 5.3 | −0.3 ± 2.3 | 134.2 ± 3.7 | 123.8 ± 3.1 | −10.4 ± 3.2 | −10.1 (−19.7 to −0.5) | 0.041 |
Diastolic | 70.3 ± 2.1 | 70.3 ± 2.2 | 0 ± 1.8 | 72.5 ± 1.7 | 67.7 ± 2.2 | −4.8 ± 1.5 | −4.8 (−11.2 to 1.5) | 0.12 |
Mean arterial pressure | 91.4 ± 1.8 | 91.1 ± 2.9 | −0.3 ± 1.9 | 94.8 ± 1.6 | 88.2 ± 1.6 | −6.6 ± 2.0 | −6.3 (−12.8 to 0.8) | 0.065 |
GFR (ml · min−1 · 1.73m−2) | 101.1 ± 6.1 | 98.8 ± 6.3 | −2.3 ± 2.1 | 96.9 ± 6.7 | 91.9 ± 5.9 | −5.0 ± 1.7 | −2.7 (−8.1 to 2.6) | 0.28 |
MAG-3 ERPF (ml · min−1 · 1.73 m−2) | 272.9 ± 21.8 | 267.3 ± 23.4 | −5.6 ± 9.9 | 275.5 ± 20.9 | 269.2 ± 19.6 | −6.3 ± 9.3 | −0.7 (−26 to 25) | 0.95 |
FF (%) | 20.1 ± 1.0 | 20.2 ± 1.3 | 0.2 ± 1.0 | 18.8 ± 0.8 | 18.2 ± 0.6 | −0.6 ± 0.4 | −0.7 (−3.3 to 1.8) | 0.53 |
PGC (mmHg) | 53.3 ± 3.8 | 51.9 ± 3.6 | −1.4 ± 1.7 | 54.4 ± 3.9 | 45.4 ± 4.4 | −9.0 ± 1.7 | −7.6 (−11.8 to −3.5) | 0.002 |
Parameter . | LosartanRS . | LosartanLS . | Δ LosartanLS − Δ losartanRS . | P . | ||||
---|---|---|---|---|---|---|---|---|
Week 2 . | Week 4 . | Δ Week 4–2 . | Week 2 . | Week 4 . | ΔWeek 4–2 . | Δ . | ||
Blood pressure (mmHg) | ||||||||
24-h | ||||||||
Systolic | 139.6 ± 3.9 | 139.6 ± 4.8 | 0 ± 2.1 | 141.4 ± 4.0 | 131.7 ± 3.5 | −9.7 ± 2.7 | −9.7 (−17.2 to −2.2) | 0.002 |
Diastolic | 77.8 ± 1.5 | 78.2 ± 1.8 | 0.4 ± 0.9 | 78.9 ± 1.2 | 73.8 ± 1.8 | −5.1 ± 1.4 | −5.5 (−8.4 to −2.6) | 0.002 |
Mean arterial pressure | 99.3 ± 1.9 | 98.9 ± 2.4 | −0.4 ± 1.5 | 100.6 ± 1.8 | 92.9 ± 1.9 | −7.7 ± 1.7 | −7.3 (−11.3 to −3.3) | 0.003 |
Awake | ||||||||
Systolic | 142.5 ± 4 | 142.1 ± 4.9 | −0.4 ± 2.2 | 143.5 ± 4.5 | 133.6 ± 4.0 | −9.9 ± 3.2 | −9.5 (−18.4 to −0.6) | 0.039 |
Diastolic | 80.2 ± 1.6 | 80.1 ± 1.8 | −0.1 ± 0.8 | 80.7 ± 1.4 | 75.3 ± 2.0 | −5.4 ± 1.8 | −5.3 (−9.3 to −1.3) | 0.015 |
Mean arterial pressure | 101.8 ± 2.1 | 100.5 ± 2.3 | −1.3 ± 1.4 | 101.1 ± 2.7 | 94.1 ± 2.4 | −7.0 ± 2.6 | −5.7 (−11.3 to −0.1) | 0.048 |
Sleep | ||||||||
Systolic | 129.9 ± 3.4 | 129.6 ± 5.3 | −0.3 ± 2.3 | 134.2 ± 3.7 | 123.8 ± 3.1 | −10.4 ± 3.2 | −10.1 (−19.7 to −0.5) | 0.041 |
Diastolic | 70.3 ± 2.1 | 70.3 ± 2.2 | 0 ± 1.8 | 72.5 ± 1.7 | 67.7 ± 2.2 | −4.8 ± 1.5 | −4.8 (−11.2 to 1.5) | 0.12 |
Mean arterial pressure | 91.4 ± 1.8 | 91.1 ± 2.9 | −0.3 ± 1.9 | 94.8 ± 1.6 | 88.2 ± 1.6 | −6.6 ± 2.0 | −6.3 (−12.8 to 0.8) | 0.065 |
GFR (ml · min−1 · 1.73m−2) | 101.1 ± 6.1 | 98.8 ± 6.3 | −2.3 ± 2.1 | 96.9 ± 6.7 | 91.9 ± 5.9 | −5.0 ± 1.7 | −2.7 (−8.1 to 2.6) | 0.28 |
MAG-3 ERPF (ml · min−1 · 1.73 m−2) | 272.9 ± 21.8 | 267.3 ± 23.4 | −5.6 ± 9.9 | 275.5 ± 20.9 | 269.2 ± 19.6 | −6.3 ± 9.3 | −0.7 (−26 to 25) | 0.95 |
FF (%) | 20.1 ± 1.0 | 20.2 ± 1.3 | 0.2 ± 1.0 | 18.8 ± 0.8 | 18.2 ± 0.6 | −0.6 ± 0.4 | −0.7 (−3.3 to 1.8) | 0.53 |
PGC (mmHg) | 53.3 ± 3.8 | 51.9 ± 3.6 | −1.4 ± 1.7 | 54.4 ± 3.9 | 45.4 ± 4.4 | −9.0 ± 1.7 | −7.6 (−11.8 to −3.5) | 0.002 |
Data expressed as means ± SEM or mean difference (95% CI).