Parameter . | PlaceboRS . | PlaceboLS . | Δ PlaceboLS − Δ placeboRS . | P . | ||||
---|---|---|---|---|---|---|---|---|
Week 2 . | Week 4 . | Δ Week 4–2 . | Week 2 . | Week 4 . | Δ Week 4–2 . | Δ . | ||
Blood pressure (mmHg) | ||||||||
24-h | ||||||||
Systolic | 138.6 ± 4.2 | 137.5 ± 4.0 | −1.1 ± 2.1 | 131.9 ± 4.5 | 132.6 ± 4.6 | 0.7 ± 2.7 | 1.8 (−5.9 to 9.5) | NS |
Diastolic | 81.9 ± 3.1 | 80.9 ± 2.7 | −1 ± 1.1 | 77.3 ± 1.9 | 79.6 ± 2.7 | 2.3 ± 1.9 | 3.3 (−1.7 to 8.3) | NS |
Mean arterial pressure | 100.8 ± 2.9 | 100.4 ± 2.8 | −0.4 ± 1.5 | 97.5 ± 2.9 | 97.0 ± 2.8 | −0.5 ± 2.0 | −0.1 (−5.9 to 5.7) | NS |
Awake | ||||||||
Systolic | 141.8 ± 4.4 | 141.5 ± 4.1 | −0.3 ± 2.4 | 135.1 ± 4.7 | 135.1 ± 4.8 | 0 ± 2.7 | 0.3 (−7.9 to 8.5) | NS |
Diastolic | 84.2 ± 3.3 | 83.4 ± 2.7 | −0.8 ± 1.3 | 82.3 ± 3.0 | 81.7 ± 2.9 | −0.6 ± 1.8 | 0.2 (−4.6 to 5.0) | NS |
Mean arterial pressure | 103.2 ± 3.2 | 103.1 ± 2.9 | −0.1 ± 1.8 | 100.3 ± 3.0 | 98.9 ± 3.1 | −1.4 ± 2.2 | −1.3 (−7.7 to 5.1) | NS |
Sleep | ||||||||
Systolic | 124.8 ± 4.1 | 122.2 ± 3.6 | −2.6 ± 2.4 | 121.0 ± 4.1 | 122.4 ± 3.8 | 1.4 ± 3.0 | 4.0 (−3.7 to 11.7) | NS |
Diastolic | 72.4 ± 3.3 | 71.4 ± 2.4 | −1.0 ± 1.7 | 67.8 ± 1.9 | 72.1 ± 2.9 | 4.3 ± 2.5 | 5.3 (−2.0 to 12.6) | NS |
Mean arterial pressure | 93.3 ± 3.1 | 89.7 ± 2.5 | −1.6 ± 1.4 | 88.1 ± 2.5 | 89.4 ± 2.5 | 1.3 ± 2.1 | 2.9 (−3.3 to 9.1) | NS |
GFR (ml · min−1 · 1.73 m−2) | 100.7 ± 5.4 | 100.5 ± 4.0 | −0.2 ± 2.1 | 99.0 ± 4.7 | 95.0 ± 4.6 | −4.0 ± 2.0 | −3.8 (−9.4 to 1.9) | NS |
MAG-3 ERPF (ml · min−1 · 1.73 m−2) | 270.7 ± 20.8 | 276.3 ± 19.1 | 5.6 ± 14.9 | 267.7 ± 21.5 | 272.0 ± 20.2 | 4.3 ± 15 | −1.3 (−53 to 50) | NS |
FF (%) | 20.3 ± 1.2 | 19.7 ± 0.8 | −0.6 ± 1.2 | 20.2 ± 1.1 | 18.9 ± 0.7 | −1.3 ± 1.0 | −0.8 (−4.7 to 3.1) | NS |
PGC (mmHg) | 42.5 ± 2.6 | 41.0 ± 3.7 | −1.5 ± 2.0 | 39.0 ± 2.9 | 36.4 ± 3.3 | −2.5 ± 2.5 | −1.0 (−7.8 to 5.7) | NS |
Parameter . | PlaceboRS . | PlaceboLS . | Δ PlaceboLS − Δ placeboRS . | P . | ||||
---|---|---|---|---|---|---|---|---|
Week 2 . | Week 4 . | Δ Week 4–2 . | Week 2 . | Week 4 . | Δ Week 4–2 . | Δ . | ||
Blood pressure (mmHg) | ||||||||
24-h | ||||||||
Systolic | 138.6 ± 4.2 | 137.5 ± 4.0 | −1.1 ± 2.1 | 131.9 ± 4.5 | 132.6 ± 4.6 | 0.7 ± 2.7 | 1.8 (−5.9 to 9.5) | NS |
Diastolic | 81.9 ± 3.1 | 80.9 ± 2.7 | −1 ± 1.1 | 77.3 ± 1.9 | 79.6 ± 2.7 | 2.3 ± 1.9 | 3.3 (−1.7 to 8.3) | NS |
Mean arterial pressure | 100.8 ± 2.9 | 100.4 ± 2.8 | −0.4 ± 1.5 | 97.5 ± 2.9 | 97.0 ± 2.8 | −0.5 ± 2.0 | −0.1 (−5.9 to 5.7) | NS |
Awake | ||||||||
Systolic | 141.8 ± 4.4 | 141.5 ± 4.1 | −0.3 ± 2.4 | 135.1 ± 4.7 | 135.1 ± 4.8 | 0 ± 2.7 | 0.3 (−7.9 to 8.5) | NS |
Diastolic | 84.2 ± 3.3 | 83.4 ± 2.7 | −0.8 ± 1.3 | 82.3 ± 3.0 | 81.7 ± 2.9 | −0.6 ± 1.8 | 0.2 (−4.6 to 5.0) | NS |
Mean arterial pressure | 103.2 ± 3.2 | 103.1 ± 2.9 | −0.1 ± 1.8 | 100.3 ± 3.0 | 98.9 ± 3.1 | −1.4 ± 2.2 | −1.3 (−7.7 to 5.1) | NS |
Sleep | ||||||||
Systolic | 124.8 ± 4.1 | 122.2 ± 3.6 | −2.6 ± 2.4 | 121.0 ± 4.1 | 122.4 ± 3.8 | 1.4 ± 3.0 | 4.0 (−3.7 to 11.7) | NS |
Diastolic | 72.4 ± 3.3 | 71.4 ± 2.4 | −1.0 ± 1.7 | 67.8 ± 1.9 | 72.1 ± 2.9 | 4.3 ± 2.5 | 5.3 (−2.0 to 12.6) | NS |
Mean arterial pressure | 93.3 ± 3.1 | 89.7 ± 2.5 | −1.6 ± 1.4 | 88.1 ± 2.5 | 89.4 ± 2.5 | 1.3 ± 2.1 | 2.9 (−3.3 to 9.1) | NS |
GFR (ml · min−1 · 1.73 m−2) | 100.7 ± 5.4 | 100.5 ± 4.0 | −0.2 ± 2.1 | 99.0 ± 4.7 | 95.0 ± 4.6 | −4.0 ± 2.0 | −3.8 (−9.4 to 1.9) | NS |
MAG-3 ERPF (ml · min−1 · 1.73 m−2) | 270.7 ± 20.8 | 276.3 ± 19.1 | 5.6 ± 14.9 | 267.7 ± 21.5 | 272.0 ± 20.2 | 4.3 ± 15 | −1.3 (−53 to 50) | NS |
FF (%) | 20.3 ± 1.2 | 19.7 ± 0.8 | −0.6 ± 1.2 | 20.2 ± 1.1 | 18.9 ± 0.7 | −1.3 ± 1.0 | −0.8 (−4.7 to 3.1) | NS |
PGC (mmHg) | 42.5 ± 2.6 | 41.0 ± 3.7 | −1.5 ± 2.0 | 39.0 ± 2.9 | 36.4 ± 3.3 | −2.5 ± 2.5 | −1.0 (−7.8 to 5.7) | NS |
Data means ± SEM or mean difference (95% CI).