. | Losartan . | Placebo . | ||||||
---|---|---|---|---|---|---|---|---|
Week 0 . | Week 2 . | Week 4 . | ANOVA . | Week 0 . | Week 2 . | Week 4 . | ANOVA . | |
Urinary sodium excretion | ||||||||
Regular-sodium diet | 255 ± 33 | 222 ± 23 | 208 ± 20 | NS | 208 ± 15 | 207 ± 27 | 204 ± 27 | NS |
Low-sodium diet | 225 ± 24 | 226 ± 25 | 85 ± 14†§ | <0.0001 | 205 ± 29 | 163 ± 17 | 80 ± 22†§ | 0.0007 |
Fasting plasma glucose (mmol/l) | ||||||||
Regular-sodium diet | 10.5 ± 1.3 | 9.8 ± 1.2 | 9.3 ± 1.2 | NS | 9.8 ± 1.4 | 10.7 ± 1.2 | 9.6 ± 1.4 | NS |
Low-sodium diet | 9.1 ± 0.7 | 8.9 ± 0.7 | 7.7 ± 0.6* | 0.046 | 9.8 ± 0.7 | 9.1 ± 0.7 | 8.5 ± 1.5 | NS |
PRA (ng · ml−1 · h−1) | ||||||||
Regular-sodium diet | 0.47 (1.28) | 1.31 (1.63)† | 1.09 (1.52)† | 0.0004 | 0.49 (1.31) | 0.51 (1.27) | 0.43 (1.27) | NS |
Low-sodium diet | 0.57 (1.29) | 0.99 (1.46) | 3.07 (1.63)†§ | <0.0001 | 0.57 (1.31) | 0.57 (1.3) | 0.92 (1.3)†‡ | <0.01 |
Plasma ANG-II (pg/ml) | ||||||||
Regular-sodium diet | 4.51 (1.24) | 8.25 (1.41)† | 10.04 (1.41)† | 0.001 | 6.84 (1.29) | 5.82 (1.25) | 6.49 (1.21) | NS |
Low-sodium diet | 5.65 (1.29) | 9.16 (1.4) | 24.71 (1.53)†§ | 0.0002 | 6.06 (1.19) | 6.65 (1.37) | 10.8 (1.16)*‡ | 0.02 |
Plasma aldosterone (pmol/l) | ||||||||
Regular-sodium diet | 188.1 ± 33.3 | 273 ± 76.7 | 190.8 ± 38.7 | NS | 200.7 ± 43.2 | 233.4 ± 52.5 | 208.4 ± 31.4 | NS |
Low-sodium diet | 209 ± 32.3 | 166.9 ± 34.5 | 345.3 ± 51.5†§ | 0.0009 | 173.9 ± 36.8 | 192 ± 34.5 | 401 ± 53.4†§ | <0.0001 |
. | Losartan . | Placebo . | ||||||
---|---|---|---|---|---|---|---|---|
Week 0 . | Week 2 . | Week 4 . | ANOVA . | Week 0 . | Week 2 . | Week 4 . | ANOVA . | |
Urinary sodium excretion | ||||||||
Regular-sodium diet | 255 ± 33 | 222 ± 23 | 208 ± 20 | NS | 208 ± 15 | 207 ± 27 | 204 ± 27 | NS |
Low-sodium diet | 225 ± 24 | 226 ± 25 | 85 ± 14†§ | <0.0001 | 205 ± 29 | 163 ± 17 | 80 ± 22†§ | 0.0007 |
Fasting plasma glucose (mmol/l) | ||||||||
Regular-sodium diet | 10.5 ± 1.3 | 9.8 ± 1.2 | 9.3 ± 1.2 | NS | 9.8 ± 1.4 | 10.7 ± 1.2 | 9.6 ± 1.4 | NS |
Low-sodium diet | 9.1 ± 0.7 | 8.9 ± 0.7 | 7.7 ± 0.6* | 0.046 | 9.8 ± 0.7 | 9.1 ± 0.7 | 8.5 ± 1.5 | NS |
PRA (ng · ml−1 · h−1) | ||||||||
Regular-sodium diet | 0.47 (1.28) | 1.31 (1.63)† | 1.09 (1.52)† | 0.0004 | 0.49 (1.31) | 0.51 (1.27) | 0.43 (1.27) | NS |
Low-sodium diet | 0.57 (1.29) | 0.99 (1.46) | 3.07 (1.63)†§ | <0.0001 | 0.57 (1.31) | 0.57 (1.3) | 0.92 (1.3)†‡ | <0.01 |
Plasma ANG-II (pg/ml) | ||||||||
Regular-sodium diet | 4.51 (1.24) | 8.25 (1.41)† | 10.04 (1.41)† | 0.001 | 6.84 (1.29) | 5.82 (1.25) | 6.49 (1.21) | NS |
Low-sodium diet | 5.65 (1.29) | 9.16 (1.4) | 24.71 (1.53)†§ | 0.0002 | 6.06 (1.19) | 6.65 (1.37) | 10.8 (1.16)*‡ | 0.02 |
Plasma aldosterone (pmol/l) | ||||||||
Regular-sodium diet | 188.1 ± 33.3 | 273 ± 76.7 | 190.8 ± 38.7 | NS | 200.7 ± 43.2 | 233.4 ± 52.5 | 208.4 ± 31.4 | NS |
Low-sodium diet | 209 ± 32.3 | 166.9 ± 34.5 | 345.3 ± 51.5†§ | 0.0009 | 173.9 ± 36.8 | 192 ± 34.5 | 401 ± 53.4†§ | <0.0001 |
Data for PRA and ANG-II are geometric means (tolerance factor); data for urinary sodium excretion, fasting plasma glucose, and aldosterone are expressed as means ± SEM.
P < 0.05 vs. week 0;
P < 0.01 vs. week 0;
P < 0.05 vs. week 2;
P < 0.01 vs. week 2.