. | Losartan . | Placebo . |
---|---|---|
n | 117 | 135 |
Clinical characteristics | ||
Age (years) | 59.7 ± 7.1 | 59.4 ± 7.5 |
Men | 84 (71.8) | 87 (64.4) |
Smoking | 29 (24.8) | 23 (17.0) |
Duration of diabetes (years) | 15.0 ± 8.1 | 14.7 ± 8.3 |
Duration of diabetes ≥5 years | 103 (88.0) | 123 (91.1) |
Duration of hypertension (years) | 7.9 (8.1) | 8.5 (8.0) |
Duration of hypertension ≥ 10 years | 33 (28.2) | 40 (29.6) |
BMI (kg/m2) | 25.2 ± 4.7 | 24.8 ± 4.3 |
Systolic blood pressure (mmHg) | 152.1 ± 19.1 | 151.5 ± 19.6 |
Diastolic blood pressure (mmHg) | 81.9 ± 10.5 | 82.9 ± 11.1 |
Mean arterial pressure (mmHg) | 105.3 ± 10.8 | 104.6 (11.9) |
Pulse rate (bpm) | 76.3 (10.8) | 75.2 (9.6) |
Medical history | ||
Angina pectoris | 9 (7.7) | 13 (9.6) |
Myocardial infarction | 5 (4.3) | 8 (5.9) |
Amputation | 3 (2.6) | 5 (3.7) |
Retinopathy | 87 (74.4) | 90 (66.7) |
Laser therapy | 25 (21.4) | 26 (19.3) |
Laboratory values | ||
Urinary albumin-to-creatinine ratio (mg/g)* | 3.1 ± 0.5 | 3.1 ± 0.4 |
Calculated glomerular filtration rate (ml/min) | 37.7 ± 9.8 | 37.5 ± 11.6 |
Serum creatinine (mg/dl) | 1.9 ± 0.4 | 1.9 ± 0.5 |
Serum albumin (g/dl) | 3.8 ± 0.5 | 3.8 ± 0.4 |
Total cholesterol (mg/dl) | 228.8 ± 54.7 | 227.3 ± 48.2 |
LDL cholesterol (mg/dl) | 144.2 ± 49.3 | 144.6 ± 46.8 |
HDL cholesterol (mg/dl) | 45.7 ± 16.3 | 46.9 ± 17.4 |
Triglyceride (mg/dl) | 208.1 ± 200.6 | 207.1 ± 161.1 |
Serum uric acid (mg/dl) | 6.63 ± 1.4 | 6.9 ± 1.8 |
Hb (%) | 12.3 ± 2.1 | 12.1 ± 2.0 |
GHb (%) | 8.3 ± 1.5 | 8.0 ± 1.4 |
White blood cell count × 106/cc9 | 7.5 ± 1.7 | 7.1 ± 1.7 |
Pattern of drug usage | ||
Dihydropyridine calcium channel blockers | 84 (71.8) | 101 (74.8) |
Nondihydropyridine calcium channel blockers | 12 (10.3) | 10 (7.4) |
Diuretics | 43 (36.8) | 44 (32.6) |
β-Blockers | 20 (17.1) | 19 (14.1) |
ACE inhibitors/AII antagonists | 70 (59.8) | 69 (51.1) |
α-Blockers | 23 (19.7) | 26 (19.3) |
Insulin | 64 (54.7) | 65 (48.1) |
. | Losartan . | Placebo . |
---|---|---|
n | 117 | 135 |
Clinical characteristics | ||
Age (years) | 59.7 ± 7.1 | 59.4 ± 7.5 |
Men | 84 (71.8) | 87 (64.4) |
Smoking | 29 (24.8) | 23 (17.0) |
Duration of diabetes (years) | 15.0 ± 8.1 | 14.7 ± 8.3 |
Duration of diabetes ≥5 years | 103 (88.0) | 123 (91.1) |
Duration of hypertension (years) | 7.9 (8.1) | 8.5 (8.0) |
Duration of hypertension ≥ 10 years | 33 (28.2) | 40 (29.6) |
BMI (kg/m2) | 25.2 ± 4.7 | 24.8 ± 4.3 |
Systolic blood pressure (mmHg) | 152.1 ± 19.1 | 151.5 ± 19.6 |
Diastolic blood pressure (mmHg) | 81.9 ± 10.5 | 82.9 ± 11.1 |
Mean arterial pressure (mmHg) | 105.3 ± 10.8 | 104.6 (11.9) |
Pulse rate (bpm) | 76.3 (10.8) | 75.2 (9.6) |
Medical history | ||
Angina pectoris | 9 (7.7) | 13 (9.6) |
Myocardial infarction | 5 (4.3) | 8 (5.9) |
Amputation | 3 (2.6) | 5 (3.7) |
Retinopathy | 87 (74.4) | 90 (66.7) |
Laser therapy | 25 (21.4) | 26 (19.3) |
Laboratory values | ||
Urinary albumin-to-creatinine ratio (mg/g)* | 3.1 ± 0.5 | 3.1 ± 0.4 |
Calculated glomerular filtration rate (ml/min) | 37.7 ± 9.8 | 37.5 ± 11.6 |
Serum creatinine (mg/dl) | 1.9 ± 0.4 | 1.9 ± 0.5 |
Serum albumin (g/dl) | 3.8 ± 0.5 | 3.8 ± 0.4 |
Total cholesterol (mg/dl) | 228.8 ± 54.7 | 227.3 ± 48.2 |
LDL cholesterol (mg/dl) | 144.2 ± 49.3 | 144.6 ± 46.8 |
HDL cholesterol (mg/dl) | 45.7 ± 16.3 | 46.9 ± 17.4 |
Triglyceride (mg/dl) | 208.1 ± 200.6 | 207.1 ± 161.1 |
Serum uric acid (mg/dl) | 6.63 ± 1.4 | 6.9 ± 1.8 |
Hb (%) | 12.3 ± 2.1 | 12.1 ± 2.0 |
GHb (%) | 8.3 ± 1.5 | 8.0 ± 1.4 |
White blood cell count × 106/cc9 | 7.5 ± 1.7 | 7.1 ± 1.7 |
Pattern of drug usage | ||
Dihydropyridine calcium channel blockers | 84 (71.8) | 101 (74.8) |
Nondihydropyridine calcium channel blockers | 12 (10.3) | 10 (7.4) |
Diuretics | 43 (36.8) | 44 (32.6) |
β-Blockers | 20 (17.1) | 19 (14.1) |
ACE inhibitors/AII antagonists | 70 (59.8) | 69 (51.1) |
α-Blockers | 23 (19.7) | 26 (19.3) |
Insulin | 64 (54.7) | 65 (48.1) |
Data are means ± SE or n (%).
Log transformed.