Class . | Compound(s) . | Dosage strength/product (if applicable) . | Median AWP (min, max)† . | Median NADAC (min, max)† . | Maximum approved daily dose* . |
---|---|---|---|---|---|
Biguanides | • Metformin | 850 mg (IR) | $108 ($6, $109) | $3 | 2,550 mg |
1,000 mg (IR) | $87 ($4, $88) | $2 | 2,000 mg | ||
1,000 mg (ER) | $242 ($242, $7,214) | $188 ($188, $572) | 2,000 mg | ||
Sulfonylureas (2nd generation) | • Glimepiride | 4 mg | $74 ($71, $198) | $4 | 8 mg |
• Glipizide | 10 mg (IR) | $75 ($67, $97) | $5 | 40 mg (IR) | |
10 mg (XL) | $48 | $11 | 20 mg (XL) | ||
• Glyburide | 6 mg (micronized) | $52 ($48, $71) | $10 | 12 mg (micronized) | |
5 mg | $93 ($63, $103) | $11 | 20 mg | ||
Thiazolidinediones | • Pioglitazone | 45 mg | $348 ($283, $349) | $5 | 45 mg |
• Rosiglitazone | 4 mg | $407 | $330 | 8 mg | |
α-Glucosidase inhibitors | • Acarbose | 100 mg | $106 ($104, $106) | $28 | 300 mg |
• Miglitol | 100 mg | $241 | $311 | 300 mg | |
Meglitinides (glinides) | • Nateglinide | 120 mg | $155 | $31 | 360 mg |
• Repaglinide | 2 mg | $878 ($162, $897) | $38 | 16 mg | |
DPP-4 inhibitors | • Alogliptin | 25 mg | $234 | $175 | 25 mg |
• Saxagliptin | 5 mg | $530 | $424 | 5 mg | |
• Linagliptin | 5 mg | $555 | $444 | 5 mg | |
• Sitagliptin | 100 mg | $568 | $456 | 100 mg | |
SGLT2 inhibitors | • Ertugliflozin | 15 mg | $354 | $284 | 15 mg |
• Dapagliflozin | 10 mg | $621 | $496 | 10 mg | |
• Empagliflozin | 25 mg | $627 | $501 | 25 mg | |
• Canagliflozin | 300 mg | $622 | $499 | 300 mg | |
GLP-1 RAs | • Exenatide (extended release) | 2 mg powder for suspension or pen | $882 | $706 | 2 mg** |
• Exenatide | 10 µg pen | $752 | $720 | 20 µg | |
• Dulaglutide | 4.5/0.5 mL pen | $957 | $766 | 4.5 mg** | |
• Semaglutide | 1 mg pen | $973 | $779 | 1 mg** | |
14 mg (tablet) | $927 | $738 | 14 mg | ||
• Liraglutide | 18 mg/3 mL pen | $1,161 | $930 | 1.8 mg | |
• Lixisenatide | 300 µg/3 mL pen | $774 | N/A | 20 µg | |
Bile acid sequestrant | • Colesevelam | 625 mg tabs | $710 ($674, $712) | $105 | 3.75 g |
3.75 g suspension | $804 | $318 | 3.75 g | ||
Dopamine-2 agonist | • Bromocriptine | 0.8 mg | $960 | $772 | 4.8 mg |
Amylin mimetic | • Pramlintide | 120 µg pen | $2702 | $2,097 | 120 µg/injection†† |
Class . | Compound(s) . | Dosage strength/product (if applicable) . | Median AWP (min, max)† . | Median NADAC (min, max)† . | Maximum approved daily dose* . |
---|---|---|---|---|---|
Biguanides | • Metformin | 850 mg (IR) | $108 ($6, $109) | $3 | 2,550 mg |
1,000 mg (IR) | $87 ($4, $88) | $2 | 2,000 mg | ||
1,000 mg (ER) | $242 ($242, $7,214) | $188 ($188, $572) | 2,000 mg | ||
Sulfonylureas (2nd generation) | • Glimepiride | 4 mg | $74 ($71, $198) | $4 | 8 mg |
• Glipizide | 10 mg (IR) | $75 ($67, $97) | $5 | 40 mg (IR) | |
10 mg (XL) | $48 | $11 | 20 mg (XL) | ||
• Glyburide | 6 mg (micronized) | $52 ($48, $71) | $10 | 12 mg (micronized) | |
5 mg | $93 ($63, $103) | $11 | 20 mg | ||
Thiazolidinediones | • Pioglitazone | 45 mg | $348 ($283, $349) | $5 | 45 mg |
• Rosiglitazone | 4 mg | $407 | $330 | 8 mg | |
α-Glucosidase inhibitors | • Acarbose | 100 mg | $106 ($104, $106) | $28 | 300 mg |
• Miglitol | 100 mg | $241 | $311 | 300 mg | |
Meglitinides (glinides) | • Nateglinide | 120 mg | $155 | $31 | 360 mg |
• Repaglinide | 2 mg | $878 ($162, $897) | $38 | 16 mg | |
DPP-4 inhibitors | • Alogliptin | 25 mg | $234 | $175 | 25 mg |
• Saxagliptin | 5 mg | $530 | $424 | 5 mg | |
• Linagliptin | 5 mg | $555 | $444 | 5 mg | |
• Sitagliptin | 100 mg | $568 | $456 | 100 mg | |
SGLT2 inhibitors | • Ertugliflozin | 15 mg | $354 | $284 | 15 mg |
• Dapagliflozin | 10 mg | $621 | $496 | 10 mg | |
• Empagliflozin | 25 mg | $627 | $501 | 25 mg | |
• Canagliflozin | 300 mg | $622 | $499 | 300 mg | |
GLP-1 RAs | • Exenatide (extended release) | 2 mg powder for suspension or pen | $882 | $706 | 2 mg** |
• Exenatide | 10 µg pen | $752 | $720 | 20 µg | |
• Dulaglutide | 4.5/0.5 mL pen | $957 | $766 | 4.5 mg** | |
• Semaglutide | 1 mg pen | $973 | $779 | 1 mg** | |
14 mg (tablet) | $927 | $738 | 14 mg | ||
• Liraglutide | 18 mg/3 mL pen | $1,161 | $930 | 1.8 mg | |
• Lixisenatide | 300 µg/3 mL pen | $774 | N/A | 20 µg | |
Bile acid sequestrant | • Colesevelam | 625 mg tabs | $710 ($674, $712) | $105 | 3.75 g |
3.75 g suspension | $804 | $318 | 3.75 g | ||
Dopamine-2 agonist | • Bromocriptine | 0.8 mg | $960 | $772 | 4.8 mg |
Amylin mimetic | • Pramlintide | 120 µg pen | $2702 | $2,097 | 120 µg/injection†† |
AWP, average wholesale price; DPP-4, dipeptidyl peptidase 4; ER and XL, extended release; GLP-1 RA, glucagon-like peptide 1 receptor agonist; IR, immediate release; max, maximum; min, minimum; N/A, data not available; NADAC, National Average Drug Acquisition Cost; SGLT2, sodium–glucose cotransporter 2. †Calculated for 30-day supply (AWP [62] or NADAC [63] unit price × number of doses required to provide maximum approved daily dose × 30 days); median AWP or NADAC listed alone when only one product and/or price.
Utilized to calculate median AWP and NADAC (min, max); generic prices used, if available commercially.
Administered once weekly.
AWP and NADAC calculated based on 120 mg three times daily.