. | OR (95% CI) . | aOR (95% CI)* . | P . |
---|---|---|---|
DBP, per 1 μmol/L increase | |||
Predicted maternal DBP† | 0.74 (0.39–1.22) | 0.49 (0.18–1.02) | NS‡ |
Midpregnancy | 1.03 (0.91–1.16) | 0.96 (0.79–1.16) | 0.65 |
Cord blood | 0.98 (0.81–1.20) | 0.87 (0.67–1.14) | 0.32 |
Postpartum | 0.86 (0.74–0.98) | 0.80 (0.67–0.95) | 0.01 |
25(OH)D-to-DBP ratio | |||
Midpregnancy | 1.00 (0.96–1.04) | 1.04 (0.98–1.09) | 0.17 |
Cord blood | 0.99 (0.97–1.01) | 1.00 (0.97–1.04) | 0.81 |
Postpartum | 1.01 (0.98–1.04) | 1.05 (1.00–1.10) | 0.049 |
25(OH)D, per 10 nmol/L increase, stratified by VDR rs11568820§ | |||
Cord blood, AA/AG | 1.18 (1.00–1.40) | 1.17 (0.95–1.44) | 0.15 |
Cord blood, GG | 0.87 (0.77–0.98) | 0.85 (0.72–1.00) | 0.047 |
. | OR (95% CI) . | aOR (95% CI)* . | P . |
---|---|---|---|
DBP, per 1 μmol/L increase | |||
Predicted maternal DBP† | 0.74 (0.39–1.22) | 0.49 (0.18–1.02) | NS‡ |
Midpregnancy | 1.03 (0.91–1.16) | 0.96 (0.79–1.16) | 0.65 |
Cord blood | 0.98 (0.81–1.20) | 0.87 (0.67–1.14) | 0.32 |
Postpartum | 0.86 (0.74–0.98) | 0.80 (0.67–0.95) | 0.01 |
25(OH)D-to-DBP ratio | |||
Midpregnancy | 1.00 (0.96–1.04) | 1.04 (0.98–1.09) | 0.17 |
Cord blood | 0.99 (0.97–1.01) | 1.00 (0.97–1.04) | 0.81 |
Postpartum | 1.01 (0.98–1.04) | 1.05 (1.00–1.10) | 0.049 |
25(OH)D, per 10 nmol/L increase, stratified by VDR rs11568820§ | |||
Cord blood, AA/AG | 1.18 (1.00–1.40) | 1.17 (0.95–1.44) | 0.15 |
Cord blood, GG | 0.87 (0.77–0.98) | 0.85 (0.72–1.00) | 0.047 |
P value shown for adjusted analysis. aOR, adjusted OR.
*Adjusted for child’s HLA genotype and sex and maternal ethnicity, age, prepregnancy BMI, cesarean section, and smoking.
†Using maternal (midpregnancy and postpartum) samples in a mixed model to predict maternal DBP values at gestational week 36. Owing to the reduction of the sampling variation in prediction of maternal DBP, the predicted values have a lower SD of 0.35 (while, e.g., DBP in the postpartum samples has an SD of 1.52). This results in a greater observed estimate, as an increase per unit is roughly equivalent to 3 SD in this analysis. We used bootstrapping (10,000 replications) to obtain unbiased CIs and present bias-corrected CIs.
‡As these results arise from bootstrapping estimations, a P value is not provided.
§There was a statistically significant interaction (Pinteraction = 0.01) between rs11568820 and 25(OH)D (Supplementary Table 3).