Association of cord blood metabolites with cord C-peptide (μg/L)
| Metabolite . | Afro-Caribbean . | Northern European . | Mexican American . | Thai . | Meta-analysis . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | Q | Q test P | I2 | |
| Leucine/isoleucine | −0.0009 (0.0011) | 4.05e-01 | −0.0044 (0.0011) | 1.28e-04 | −0.0017 (0.0008) | 3.29e-02 | −0.0026 (0.0010) | 7.21e-03 | −0.0023 (0.0007) | 8.78e-04 | 5.92 | 1.15e-01 | 50.71 |
| AC C5 | 0.1383 (0.0551) | 1.25e-02 | 0.0549 (0.0572) | 3.37e-01 | 0.0643 (0.0516) | 2.14e-01 | 0.0596 (0.0477) | 2.12e-01 | 0.0777 (0.0263) | 3.09e-03 | 1.58 | 6.64e-01 | 0.00 |
| AC C3 | 0.1427 (0.0772) | 6.51e-02 | 0.1134 (0.0773) | 1.43e-01 | 0.0149 (0.0811) | 8.54e-01 | 0.0300 (0.0742) | 6.87e-01 | 0.0757 (0.0387) | 5.02e-02 | 1.94 | 5.86e-01 | 0.00 |
| Valine | −0.0002 (0.0009) | 7.84e-01 | −0.0001 (0.0010) | 8.96e-01 | −0.0015 (0.0006) | 1.65e-02 | −0.0003 (0.0007) | 6.42e-01 | −0.0007 (0.0004) | 7.70e-02 | 2.56 | 4.65e-01 | 7.47 |
| AC C4/Ci4 | 0.1134 (0.0876) | 1.96e-01 | 0.0492 (0.0777) | 5.27e-01 | 0.0045 (0.0844) | 9.58e-01 | −0.0245 (0.0796) | 7.58e-01 | 0.0331 (0.0410) | 4.19e-01 | 1.52 | 6.77e-01 | 0.00 |
| Phenylalanine | 0.0037 (0.0028) | 1.83e-01 | −0.0022 (0.0025) | 3.91e-01 | −0.0030 (0.0022) | 1.69e-01 | −0.0005 (0.0025) | 8.50e-01 | −0.0008 (0.0014) | 5.81e-01 | 3.98 | 2.64e-01 | 22.32 |
| Metabolite . | Afro-Caribbean . | Northern European . | Mexican American . | Thai . | Meta-analysis . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | Q | Q test P | I2 | |
| Leucine/isoleucine | −0.0009 (0.0011) | 4.05e-01 | −0.0044 (0.0011) | 1.28e-04 | −0.0017 (0.0008) | 3.29e-02 | −0.0026 (0.0010) | 7.21e-03 | −0.0023 (0.0007) | 8.78e-04 | 5.92 | 1.15e-01 | 50.71 |
| AC C5 | 0.1383 (0.0551) | 1.25e-02 | 0.0549 (0.0572) | 3.37e-01 | 0.0643 (0.0516) | 2.14e-01 | 0.0596 (0.0477) | 2.12e-01 | 0.0777 (0.0263) | 3.09e-03 | 1.58 | 6.64e-01 | 0.00 |
| AC C3 | 0.1427 (0.0772) | 6.51e-02 | 0.1134 (0.0773) | 1.43e-01 | 0.0149 (0.0811) | 8.54e-01 | 0.0300 (0.0742) | 6.87e-01 | 0.0757 (0.0387) | 5.02e-02 | 1.94 | 5.86e-01 | 0.00 |
| Valine | −0.0002 (0.0009) | 7.84e-01 | −0.0001 (0.0010) | 8.96e-01 | −0.0015 (0.0006) | 1.65e-02 | −0.0003 (0.0007) | 6.42e-01 | −0.0007 (0.0004) | 7.70e-02 | 2.56 | 4.65e-01 | 7.47 |
| AC C4/Ci4 | 0.1134 (0.0876) | 1.96e-01 | 0.0492 (0.0777) | 5.27e-01 | 0.0045 (0.0844) | 9.58e-01 | −0.0245 (0.0796) | 7.58e-01 | 0.0331 (0.0410) | 4.19e-01 | 1.52 | 6.77e-01 | 0.00 |
| Phenylalanine | 0.0037 (0.0028) | 1.83e-01 | −0.0022 (0.0025) | 3.91e-01 | −0.0030 (0.0022) | 1.69e-01 | −0.0005 (0.0025) | 8.50e-01 | −0.0008 (0.0014) | 5.81e-01 | 3.98 | 2.64e-01 | 22.32 |
Values are adjusted for cord glucose. All amino acids and acylcarnitines are measured in µmol/L.