Evidence of utility of genetic approaches in drug target identification in type 2 diabetes and related traits
| Retrospective: Genetic studies have yielded associated genes that are known targets for currently marketed medications. |
| Prospective: Genetic studies (in Mendelian disease) have yielded target genes for which novel drugs have been developed and approved. |
| Genes that encode existing drug targets are enriched for variants that are associated with type 2 diabetes. |
| Unbiased genomic searches can uncover loci associated with drug response. |
| Retrospective: Genetic studies have yielded associated genes that are known targets for currently marketed medications. |
| Prospective: Genetic studies (in Mendelian disease) have yielded target genes for which novel drugs have been developed and approved. |
| Genes that encode existing drug targets are enriched for variants that are associated with type 2 diabetes. |
| Unbiased genomic searches can uncover loci associated with drug response. |