Hazard ratios (95% CI) for all-cause mortality associated with diabetes status and other cardiovascular risk factors at baseline
| . | Model 1 . | Model 2 . | Model 3 . |
|---|---|---|---|
| Diabetes status | |||
| No diabetes | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Prediabetes | 1.07 (0.89, 1.28) | 1.06 (0.88, 1.27) | 1.01 (0.84, 1.22) |
| Newly diagnosed diabetes | 1.48 (1.07, 2.05) | 1.41 (1.02, 1.96) | 1.31 (0.94, 1.82) |
| Short-duration diabetes | 1.43 (1.16, 1.77) | 1.39 (1.12, 1.73) | 1.26 (1.01, 1.57) |
| Long-standing diabetes | 2.17 (1.79, 2.62) | 2.09 (1.73, 2.54) | 1.71 (1.40, 2.10) |
| Age, per 5 years | 1.74 (1.63, 1.85) | 1.72 (1.61, 1.83) | 1.55 (1.45, 1.66) |
| Male | 1.44 (1.26, 1.65) | 1.47 (1.28, 1.68) | 1.44 (1.24, 1.68) |
| Race-center | |||
| Minneapolis whites | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Jackson blacks | 1.26 (1.04, 1.53) | 1.17 (0.96, 1.44) | 1.17 (0.95, 1.39) |
| Washington whites | 1.00 (0.83, 1.20) | 0.93 (0.77, 1.12) | 0.94 (0.79, 1.14) |
| Forsyth blacks | 0.51 (0.24, 1.09) | 0.51 (0.24, 1.07) | 0.47 (0.22, 1.01) |
| Forsyth whites | 0.95 (0.78, 1.16) | 0.95 (0.78, 1.15) | 0.84 (0.68, 1.03) |
| Family history of diabetes | — | 1.03 (0.88, 1.20) | 1.04 (0.89, 1.22) |
| Education attainment | |||
| Less than high school | — | 1.47 (1.19, 1.82) | 1.32 (1.08, 1.63) |
| High school/GED | — | 1.19 (1.00, 1.40) | 1.20 (1.01, 1.42) |
| College graduate | — | 1 (Reference) | 1 (Reference) |
| Current smoking | — | — | 1.34 (1.17, 1.54) |
| Total cholesterol, per 100 mg/dL | — | — | 1.44 (0.92, 2.27) |
| HDL cholesterol, per 100 mg/dL | — | — | 0.53 (0.31, 0.90) |
| Cholesterol-lowering medication use | 0.81 (0.69, 0.96) | ||
| Systolic blood pressure, per 10 mmHg | — | — | 1.00 (0.97, 1.04) |
| Hypertension medication use | — | — | 0.79 (0.65, 0.95) |
| eGFR, per 10 mL/min/1.73 m2 | |||
| <60 mL/min/1.73 m2 | — | — | 0.77 (0.72, 0.82) |
| >60 mL/min/1.73 m2 | — | — | 0.92 (0.85, 1.00) |
| hs-CRP, log2 mg/L | — | — | 1.13 (1.08, 1.18) |
| Prevalent CVD | — | — | 1.69 (1.45, 1.97) |
| . | Model 1 . | Model 2 . | Model 3 . |
|---|---|---|---|
| Diabetes status | |||
| No diabetes | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Prediabetes | 1.07 (0.89, 1.28) | 1.06 (0.88, 1.27) | 1.01 (0.84, 1.22) |
| Newly diagnosed diabetes | 1.48 (1.07, 2.05) | 1.41 (1.02, 1.96) | 1.31 (0.94, 1.82) |
| Short-duration diabetes | 1.43 (1.16, 1.77) | 1.39 (1.12, 1.73) | 1.26 (1.01, 1.57) |
| Long-standing diabetes | 2.17 (1.79, 2.62) | 2.09 (1.73, 2.54) | 1.71 (1.40, 2.10) |
| Age, per 5 years | 1.74 (1.63, 1.85) | 1.72 (1.61, 1.83) | 1.55 (1.45, 1.66) |
| Male | 1.44 (1.26, 1.65) | 1.47 (1.28, 1.68) | 1.44 (1.24, 1.68) |
| Race-center | |||
| Minneapolis whites | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Jackson blacks | 1.26 (1.04, 1.53) | 1.17 (0.96, 1.44) | 1.17 (0.95, 1.39) |
| Washington whites | 1.00 (0.83, 1.20) | 0.93 (0.77, 1.12) | 0.94 (0.79, 1.14) |
| Forsyth blacks | 0.51 (0.24, 1.09) | 0.51 (0.24, 1.07) | 0.47 (0.22, 1.01) |
| Forsyth whites | 0.95 (0.78, 1.16) | 0.95 (0.78, 1.15) | 0.84 (0.68, 1.03) |
| Family history of diabetes | — | 1.03 (0.88, 1.20) | 1.04 (0.89, 1.22) |
| Education attainment | |||
| Less than high school | — | 1.47 (1.19, 1.82) | 1.32 (1.08, 1.63) |
| High school/GED | — | 1.19 (1.00, 1.40) | 1.20 (1.01, 1.42) |
| College graduate | — | 1 (Reference) | 1 (Reference) |
| Current smoking | — | — | 1.34 (1.17, 1.54) |
| Total cholesterol, per 100 mg/dL | — | — | 1.44 (0.92, 2.27) |
| HDL cholesterol, per 100 mg/dL | — | — | 0.53 (0.31, 0.90) |
| Cholesterol-lowering medication use | 0.81 (0.69, 0.96) | ||
| Systolic blood pressure, per 10 mmHg | — | — | 1.00 (0.97, 1.04) |
| Hypertension medication use | — | — | 0.79 (0.65, 0.95) |
| eGFR, per 10 mL/min/1.73 m2 | |||
| <60 mL/min/1.73 m2 | — | — | 0.77 (0.72, 0.82) |
| >60 mL/min/1.73 m2 | — | — | 0.92 (0.85, 1.00) |
| hs-CRP, log2 mg/L | — | — | 1.13 (1.08, 1.18) |
| Prevalent CVD | — | — | 1.69 (1.45, 1.97) |
Model 1: adjusted for age, sex, and race-center. Model 2: model 1 adjustments plus education attainment and family history of diabetes. Model 3: model 2 adjustments plus current smoking, systolic blood pressure, total cholesterol, HDL cholesterol, cholesterol-lowering medication use, log-transformed hs-CRP, eGFR with spline knot at 60 mL/min/1.73 m2, hypertension medication use, and prevalent CVD.