Performance of noninvasive tests for the diagnosis of definite NASH
| . | Predefined cutoff points . | Cohort-specific cutoff points . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cutoff . | Sensitivity . | Specificity . | PPV . | NPV . | Cutoff . | Sensitivity . | Specificity . | PPV . | NPV . | |
| Cohort-specific model* | <−0.941 >−0.123 | 74 (61–84) | 74 (63–83) | 70 (58–81) | 77 (66–86) | 0.255 | 55 (44–66) | 93 (86–97) | 86 (73–94) | 73 (64–80) |
| ALT | 40 units/L | 66 (55–75) | 72 (64–80) | 63 (53–73) | 74 (65–82) | 31 units/L | 83 (74–90) | 61 (52–70) | 61 (52–70) | 83 (74–90) |
| CK-18 | N/A | — | — | — | — | 241 units/L | 63 (52–73) | 80 (71–86) | 70 (59–80) | 74 (66–81) |
| HAIR | 2 | 96 (90–99) | 12 (7–20) | 47 (39–55) | 81 (54–96) | 3 | 57 (45–68) | 77 (68–85) | 66 (54–77) | 69 (60–77) |
| OWLiver | 0.500 | 34 (24–45) | 87 (79–92) | 64 (49–78) | 65 (57–72) | 0.016 | 66 (55–76) | 69 (60–77) | 60 (49–70) | 74 (65–82) |
| NashTest 2 | 0.250 | 92 (83–96) | 29 (21–38) | 49 (41–57) | 82 (67–92) | 0.410 | 71 (60–80) | 58 (48–67) | 56 (46–65) | 73 (62–82) |
| BARD | 2 | 98 (92–100) | 5 (2–10) | 43 (36–50) | 75 (35–97) | 2 | 98 (92–100) | 5 (2–10) | 43 (36–50) | 75 (35–97) |
| . | Predefined cutoff points . | Cohort-specific cutoff points . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cutoff . | Sensitivity . | Specificity . | PPV . | NPV . | Cutoff . | Sensitivity . | Specificity . | PPV . | NPV . | |
| Cohort-specific model* | <−0.941 >−0.123 | 74 (61–84) | 74 (63–83) | 70 (58–81) | 77 (66–86) | 0.255 | 55 (44–66) | 93 (86–97) | 86 (73–94) | 73 (64–80) |
| ALT | 40 units/L | 66 (55–75) | 72 (64–80) | 63 (53–73) | 74 (65–82) | 31 units/L | 83 (74–90) | 61 (52–70) | 61 (52–70) | 83 (74–90) |
| CK-18 | N/A | — | — | — | — | 241 units/L | 63 (52–73) | 80 (71–86) | 70 (59–80) | 74 (66–81) |
| HAIR | 2 | 96 (90–99) | 12 (7–20) | 47 (39–55) | 81 (54–96) | 3 | 57 (45–68) | 77 (68–85) | 66 (54–77) | 69 (60–77) |
| OWLiver | 0.500 | 34 (24–45) | 87 (79–92) | 64 (49–78) | 65 (57–72) | 0.016 | 66 (55–76) | 69 (60–77) | 60 (49–70) | 74 (65–82) |
| NashTest 2 | 0.250 | 92 (83–96) | 29 (21–38) | 49 (41–57) | 82 (67–92) | 0.410 | 71 (60–80) | 58 (48–67) | 56 (46–65) | 73 (62–82) |
| BARD | 2 | 98 (92–100) | 5 (2–10) | 43 (36–50) | 75 (35–97) | 2 | 98 (92–100) | 5 (2–10) | 43 (36–50) | 75 (35–97) |
Data are % (95% CI). N/A, not applicable.
Model was = 0.0941 × (HOMA-IR) + 0.0039 × (CK-18) − 1.8647.