Associations of OxGua levels with type 2 diabetes incidence
| Modeling (μg/g creatinine) . | ntotal . | ncases . | Model 1a . | Model 2b . | Model 3c . |
|---|---|---|---|---|---|
| Per 1 SDd | 7,828 | 1,328 | 1.05 (1.01; 1.09) | 1.04 (1.00; 1.09) | 1.04 (1.00; 1.09) |
| ≤98.9 | 1,565 | 285 | Ref | Ref | Ref |
| >98.9 to ≤130.7 | 1,566 | 246 | 0.96 (0.81; 1.15) | 0.98 (0.82; 1.16) | 0.98 (0.83; 1.17) |
| >130.7 to ≤165.2 | 1,566 | 263 | 1.06 (0.90; 1.26) | 1.02 (0.86; 1.21) | 1.02 (0.86; 1.21) |
| >165.2 to ≤221.8 | 1,565 | 255 | 1.06 (0.89; 1.26) | 1.03 (0.87; 1.23) | 1.03 (0.87; 1.23) |
| >221.8 | 1,566 | 279 | 1.21 (1.02; 1.43) | 1.13 (0.96; 1.34) | 1.14 (0.96; 1.35) |
| Modeling (μg/g creatinine) . | ntotal . | ncases . | Model 1a . | Model 2b . | Model 3c . |
|---|---|---|---|---|---|
| Per 1 SDd | 7,828 | 1,328 | 1.05 (1.01; 1.09) | 1.04 (1.00; 1.09) | 1.04 (1.00; 1.09) |
| ≤98.9 | 1,565 | 285 | Ref | Ref | Ref |
| >98.9 to ≤130.7 | 1,566 | 246 | 0.96 (0.81; 1.15) | 0.98 (0.82; 1.16) | 0.98 (0.83; 1.17) |
| >130.7 to ≤165.2 | 1,566 | 263 | 1.06 (0.90; 1.26) | 1.02 (0.86; 1.21) | 1.02 (0.86; 1.21) |
| >165.2 to ≤221.8 | 1,565 | 255 | 1.06 (0.89; 1.26) | 1.03 (0.87; 1.23) | 1.03 (0.87; 1.23) |
| >221.8 | 1,566 | 279 | 1.21 (1.02; 1.43) | 1.13 (0.96; 1.34) | 1.14 (0.96; 1.35) |
Data are HR (95% CI) unless otherwise indicated. Boldface type indicates statistical significance at P < 0.05. Ref, reference.
Model adjusted for alcohol consumption, triglycerides, and HDL cholesterol.
Model adjusted for BMI, smoking, alcohol consumption, use of antihypertensive medication, systolic blood pressure, HbA1c, triglycerides, HDL cholesterol, eGFR, and family history of diabetes.
Model adjusted for all baseline characteristics shown in Table 1.
1 SD = 275 μg/g creatinine.