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Table 2

Annual change in eGFR by baseline CKD status

CKD statusN§Absolute eGFR change (mL/min/1.73 m2/year)Percentage eGFR change (% per year)
Unadjusted eGFR changeAdjusted eGFR changeDifference in eGFR change (95% CI)
No CKD*      
 eGFR (≥120) 775 −2.53 (2.93) −2.53 (2.78) −1.22 (−1.50, −0.93) −1.76 (1.57) 
 eGFR (90–120) 2,684 −1.28 (2.27) −1.31 (2.23) Reference −1.24 (1.82) 
 eGFR (60–90) 2,975 −0.92 (1.95) −0.91 (1.91) 0.40 (0.26, 0.53) −1.15 (2.06) 
Albuminuric non-CKD 2,814 −2.65 (2.84) −2.51 (2.82) −1.20 (−1.37, −1.02) −2.60 (2.54) 
Albuminuric CKD 330 −1.81 (2.13) −1.75 (2.17) −0.44 (−0.74, −0.13) −3.20 (3.57) 
Nonalbuminuric CKD 424 −0.61 (1.33) −0.60 (1.28) 0.60 (0.51, 0.90) −1.10 (1.88) 
CKD statusN§Absolute eGFR change (mL/min/1.73 m2/year)Percentage eGFR change (% per year)
Unadjusted eGFR changeAdjusted eGFR changeDifference in eGFR change (95% CI)
No CKD*      
 eGFR (≥120) 775 −2.53 (2.93) −2.53 (2.78) −1.22 (−1.50, −0.93) −1.76 (1.57) 
 eGFR (90–120) 2,684 −1.28 (2.27) −1.31 (2.23) Reference −1.24 (1.82) 
 eGFR (60–90) 2,975 −0.92 (1.95) −0.91 (1.91) 0.40 (0.26, 0.53) −1.15 (2.06) 
Albuminuric non-CKD 2,814 −2.65 (2.84) −2.51 (2.82) −1.20 (−1.37, −1.02) −2.60 (2.54) 
Albuminuric CKD 330 −1.81 (2.13) −1.75 (2.17) −0.44 (−0.74, −0.13) −3.20 (3.57) 
Nonalbuminuric CKD 424 −0.61 (1.33) −0.60 (1.28) 0.60 (0.51, 0.90) −1.10 (1.88) 

Data are mean (SD) unless otherwise indicated. Adjusted for age, sex, race/ethnicity, duration of diabetes, smoking, history of CVD, baseline serum lipid levels, baseline BMI, systolic blood pressure, glycated hemoglobin, and use of RAAS blockade. Baseline eGFR is not included in the covariate set, as it is already present in joint longitudinal-survival model specification.

§

Number of people with more than two eGFR measurements including baseline measurement.

*eGFR in mL/min/1.73 m2.

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