Table 3

Adjusted effects of anxiety and depression on high-cost health care use

Predictors
High-cost health care use
Number of ED visits in 2012*
Chronic, frequent ED visitor status 2010–2012
Total hospitalization costs in 2012
High-cost status in 2012
IRR(95% CI)POR(95% CI)PRCR(95% CI)POR(95% CI)P
Anxiety 1.27 (1.21, 1.34) <0.001 2.55 (1.90, 3.44) <0.001 1.06 (0.94, 1.21) 0.33 1.29 (1.23, 1.36) <0.001 
Depression 1.13 (1.09, 1.18) <0.001 1.66 (1.29, 2.14) <0.001 1.15 (1.04, 1.26) 0.004 1.29 (1.24, 1.34) <0.001 
Predictors
High-cost health care use
Number of ED visits in 2012*
Chronic, frequent ED visitor status 2010–2012
Total hospitalization costs in 2012
High-cost status in 2012
IRR(95% CI)POR(95% CI)PRCR(95% CI)POR(95% CI)P
Anxiety 1.27 (1.21, 1.34) <0.001 2.55 (1.90, 3.44) <0.001 1.06 (0.94, 1.21) 0.33 1.29 (1.23, 1.36) <0.001 
Depression 1.13 (1.09, 1.18) <0.001 1.66 (1.29, 2.14) <0.001 1.15 (1.04, 1.26) 0.004 1.29 (1.24, 1.34) <0.001 

All models adjusted for age, sex, race/ethnicity, health plan type, overall disease burden, HbA1c, BMI, diabetes complications, other health conditions, and an anxiety × depression interaction term.

*Model included a zero-inflation factor regressed on all predictors/covariates and also number of ED visits in 2011.

†Model also adjusted for 2009–2011 cost status.

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