Locus . | Gene neighborhood . | Stage . | Genotype distributionb . | MAF . | ORadd (95% CI)c . | Pc . | Phet . | I2 . | ||
---|---|---|---|---|---|---|---|---|---|---|
Case subjects . | Control subjects . | Case subjects . | Control subjects . | |||||||
6p22.2 rs4320356 | BTN3A1 | Discovery | 112/458/435 | 81/512/664 | 0.34 | 0.27 | 1.40 (1.22–1.60) | 1.72 × 10−6 | ||
C/Ta | Replicationd | 146/668/729 | 272/1,569/1,899 | 0.31 | 0.28 | 1.19 (1.08–1.31) | 6.74 × 10−4 | 0.358 | 0.03 | |
Combined | 1.26 (1.16–1.36) | 2.70 × 10−8 | 0.131 | 0.47 | ||||||
10p14 rs3802604 | GATA3 | Discovery | 182/475/348 | 157/574/524 | 0.42 | 0.35 | 1.35 (1.18–1.53) | 4.78 × 10−6 | ||
T/Ca | Replicationd | 266/739/522 | 545/1,733/1,457 | 0.42 | 0.38 | 1.18 (1.08–1.30) | 2.75 × 10−4 | 0.080 | 0.60 | |
Combined | 1.24 (1.15–1.33) | 2.06 × 10−8 | 0.070 | 0.57 | ||||||
6p21.3 rs1770 | HLA-DQB1 | Discovery | 667/278/58 | 290/594/373 | 0.80 | 0.47 | 4.35 (3.85–5.00) | 8.95 × 10−83 | ||
A/Ga | Replicationd | 990/424/108 | 819/1,752/1,147 | 0.79 | 0.46 | 4.22 (3.79–4.72) | 1.42 × 10−147 | 0.066 | 0.63 | |
Combined | 4.28 (3.92–4.68) | 2.25 × 10−232 | 0.127 | 0.47 | ||||||
12q13.2 rs705699 | SUOX | Discovery | 113/441/451 | 67/478/712 | 0.33 | 0.24 | 1.56 (1.36–1.80) | 2.88 × 10−10 | ||
C/Ta | Replicationd | 160/664/696 | 244/1,435/2,032 | 0.32 | 0.26 | 1.41 (1.27–1.55) | 2.02 × 10−11 | 0.304 | 0.16 | |
Combined | 1.46 (1.34–1.58) | 7.48 × 10−20 | 0.082 | 0.55 |
Locus . | Gene neighborhood . | Stage . | Genotype distributionb . | MAF . | ORadd (95% CI)c . | Pc . | Phet . | I2 . | ||
---|---|---|---|---|---|---|---|---|---|---|
Case subjects . | Control subjects . | Case subjects . | Control subjects . | |||||||
6p22.2 rs4320356 | BTN3A1 | Discovery | 112/458/435 | 81/512/664 | 0.34 | 0.27 | 1.40 (1.22–1.60) | 1.72 × 10−6 | ||
C/Ta | Replicationd | 146/668/729 | 272/1,569/1,899 | 0.31 | 0.28 | 1.19 (1.08–1.31) | 6.74 × 10−4 | 0.358 | 0.03 | |
Combined | 1.26 (1.16–1.36) | 2.70 × 10−8 | 0.131 | 0.47 | ||||||
10p14 rs3802604 | GATA3 | Discovery | 182/475/348 | 157/574/524 | 0.42 | 0.35 | 1.35 (1.18–1.53) | 4.78 × 10−6 | ||
T/Ca | Replicationd | 266/739/522 | 545/1,733/1,457 | 0.42 | 0.38 | 1.18 (1.08–1.30) | 2.75 × 10−4 | 0.080 | 0.60 | |
Combined | 1.24 (1.15–1.33) | 2.06 × 10−8 | 0.070 | 0.57 | ||||||
6p21.3 rs1770 | HLA-DQB1 | Discovery | 667/278/58 | 290/594/373 | 0.80 | 0.47 | 4.35 (3.85–5.00) | 8.95 × 10−83 | ||
A/Ga | Replicationd | 990/424/108 | 819/1,752/1,147 | 0.79 | 0.46 | 4.22 (3.79–4.72) | 1.42 × 10−147 | 0.066 | 0.63 | |
Combined | 4.28 (3.92–4.68) | 2.25 × 10−232 | 0.127 | 0.47 | ||||||
12q13.2 rs705699 | SUOX | Discovery | 113/441/451 | 67/478/712 | 0.33 | 0.24 | 1.56 (1.36–1.80) | 2.88 × 10−10 | ||
C/Ta | Replicationd | 160/664/696 | 244/1,435/2,032 | 0.32 | 0.26 | 1.41 (1.27–1.55) | 2.02 × 10−11 | 0.304 | 0.16 | |
Combined | 1.46 (1.34–1.58) | 7.48 × 10−20 | 0.082 | 0.55 |
Combined, derived from discovery stage and replication stage using meta-analysis under the assumption of a fixed model (combined results appear in boldface type); Phet, P value of heterogeneity test.
aMajor/minor alleles.
bIndividuals homozygous for the minor allele/heterozygous/homozygous for the major allele in control group.
cORadd (95% CI) and Padd values were derived from logistic regression analysis with adjustment for sex and the significant eigenvectors (for the discovery and replication stage) under the assumption of an additive genetic model.
dDerived from three centers in China using meta-analysis under the assumption of a fixed model.