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Table 2

Primary outcome: GDM at 28 weeks’ gestation


Summary
Effect (95% CI)
P
Placebo (n = 204)
 
Probiotics (n = 207)
 
GDM* 25 (12.3) 38 (18.4) 1.62 (0.91–2.89) 0.10 
Fasting glucose, mmol/L [mg/dL]§ 4.3 (0.45) [77.5 (8.1)] 4.4 (0.5) [79.3 (9.0)] 0.085 (0.00053–0.17) [1.53 (0.0095–3.06)] 0.049 
1-h glucose, mmol/L [mg/dL]§ 7.5 (1.6) [135.1 (28.8)] 7.6 (1.8) [136.9 (32.4)] 0.052 (−0.27 to 0.37) [0.94 (−4.86 to 6.66)] 0.75 
2-h glucose, mmol/L [mg/dL]§ 6.3 (1.4) [113.5 (25.2)] 6.4 (1.5) [115.3 (27.0)] 0.13 (−0.15 to 0.40) [2.34 (−2.70 to 7.20)] 0.37 

Summary
Effect (95% CI)
P
Placebo (n = 204)
 
Probiotics (n = 207)
 
GDM* 25 (12.3) 38 (18.4) 1.62 (0.91–2.89) 0.10 
Fasting glucose, mmol/L [mg/dL]§ 4.3 (0.45) [77.5 (8.1)] 4.4 (0.5) [79.3 (9.0)] 0.085 (0.00053–0.17) [1.53 (0.0095–3.06)] 0.049 
1-h glucose, mmol/L [mg/dL]§ 7.5 (1.6) [135.1 (28.8)] 7.6 (1.8) [136.9 (32.4)] 0.052 (−0.27 to 0.37) [0.94 (−4.86 to 6.66)] 0.75 
2-h glucose, mmol/L [mg/dL]§ 6.3 (1.4) [113.5 (25.2)] 6.4 (1.5) [115.3 (27.0)] 0.13 (−0.15 to 0.40) [2.34 (−2.70 to 7.20)] 0.37 

*Summary: n (%). Effect: odds ratio with placebo as referent.

†Summary: mean (SD).

‡Effect: difference of means. Adjusted for BMI (25–29, 30–39, and 40+ kg/m2) and patient center (RBWH, Redcliffe, Mater).

§nplacebo = 202; nprobiotics = 205.

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