T1D centile* . | Population centile** . | GRS2 . | Specificity (%) . | Sensitivity (%) . | 1-Specificity (%) . | Youden index (j) . | T1D risk (%)*** . |
---|---|---|---|---|---|---|---|
5 | 70.2 | 11.68 | 69.5 | 94.8 | 30.5 | 0.643 | 0.9 |
10 | 79.4 | 12.36 | 78.9 | 89.4 | 21.1 | 0.683 | 1.3 |
25 | 90.6 | 13.45 | 90.4 | 77.5 | 9.6 | 0.679 | 2.4 |
50 | 96.8 | 14.60 | 96.7 | 53.7 | 3.3 | 0.505 | 4.7 |
75 | 99.1 | 15.65 | 99.1 | 30.2 | 0.9 | 0.293 | 9.1 |
90 | 99.8 | 16.54 | 99.8 | 13.2 | 0.2 | 0.130 | 15.7 |
95 | 99.9 | 17.06 | 99.9 | 7.2 | 0.1 | 0.072 | 22.8 |
T1D centile* | Population centile** | GRS1 | Specificity (%) | Sensitivity (%) | 1-Specificity (%) | Youden index (j) | T1D risk (%)*** |
5 | 53.3 | 13.48 | 51.9 | 95.9 | 48.1 | 0.478 | 0.6 |
10 | 60.7 | 14.06 | 63.9 | 92.5 | 36.1 | 0.564 | 0.8 |
25 | 73.8 | 15.07 | 81.7 | 82.9 | 18.3 | 0.646 | 1.3 |
50 | 86.1 | 16.16 | 94.0 | 56.3 | 6.0 | 0.503 | 2.7 |
75 | 93.3 | 17.17 | 98.3 | 32.6 | 1.7 | 0.308 | 5.4 |
90 | 96.5 | 17.83 | 99.5 | 18.3 | 0.5 | 0.178 | 9.9 |
95 | 97.8 | 18.19 | 99.8 | 9.0 | 0.2 | 0.088 | 11.8 |
T1D centile* | Risk category | HLA type | Specificity (%) | Sensitivity (%) | 1-Specificity (%) | Youden index (j) | T1D risk (%)*** |
— | Background | Other | 0.0 | 100.0 | 0.0 | 0.000 | 0.3 |
57.0 | Moderate | DR3/3, DR4/X | 79.1 | 77.0 | 23.0 | 0.561 | 0.6 |
81.1 | High | DR4/4 | 96.3 | 41.3 | 58.7 | 0.376 | 2.5 |
84.5 | Very High | DR3/4 | 97.2 | 37.0 | 63.1 | 0.342 | 3.8 |
T1D centile* . | Population centile** . | GRS2 . | Specificity (%) . | Sensitivity (%) . | 1-Specificity (%) . | Youden index (j) . | T1D risk (%)*** . |
---|---|---|---|---|---|---|---|
5 | 70.2 | 11.68 | 69.5 | 94.8 | 30.5 | 0.643 | 0.9 |
10 | 79.4 | 12.36 | 78.9 | 89.4 | 21.1 | 0.683 | 1.3 |
25 | 90.6 | 13.45 | 90.4 | 77.5 | 9.6 | 0.679 | 2.4 |
50 | 96.8 | 14.60 | 96.7 | 53.7 | 3.3 | 0.505 | 4.7 |
75 | 99.1 | 15.65 | 99.1 | 30.2 | 0.9 | 0.293 | 9.1 |
90 | 99.8 | 16.54 | 99.8 | 13.2 | 0.2 | 0.130 | 15.7 |
95 | 99.9 | 17.06 | 99.9 | 7.2 | 0.1 | 0.072 | 22.8 |
T1D centile* | Population centile** | GRS1 | Specificity (%) | Sensitivity (%) | 1-Specificity (%) | Youden index (j) | T1D risk (%)*** |
5 | 53.3 | 13.48 | 51.9 | 95.9 | 48.1 | 0.478 | 0.6 |
10 | 60.7 | 14.06 | 63.9 | 92.5 | 36.1 | 0.564 | 0.8 |
25 | 73.8 | 15.07 | 81.7 | 82.9 | 18.3 | 0.646 | 1.3 |
50 | 86.1 | 16.16 | 94.0 | 56.3 | 6.0 | 0.503 | 2.7 |
75 | 93.3 | 17.17 | 98.3 | 32.6 | 1.7 | 0.308 | 5.4 |
90 | 96.5 | 17.83 | 99.5 | 18.3 | 0.5 | 0.178 | 9.9 |
95 | 97.8 | 18.19 | 99.8 | 9.0 | 0.2 | 0.088 | 11.8 |
T1D centile* | Risk category | HLA type | Specificity (%) | Sensitivity (%) | 1-Specificity (%) | Youden index (j) | T1D risk (%)*** |
— | Background | Other | 0.0 | 100.0 | 0.0 | 0.000 | 0.3 |
57.0 | Moderate | DR3/3, DR4/X | 79.1 | 77.0 | 23.0 | 0.561 | 0.6 |
81.1 | High | DR4/4 | 96.3 | 41.3 | 58.7 | 0.376 | 2.5 |
84.5 | Very High | DR3/4 | 97.2 | 37.0 | 63.1 | 0.342 | 3.8 |
Risk of T1D is calculated assuming a 0.3% population prevalence of T1D.
*T1D cases in T1DGC.
**Centile in UK Biobank European population.
***Risk of T1D is calculated assuming a 0.3% population prevalence of T1D.