Measure | ADA/EASD | AACE/ACE | IDF | CDA |
Basal algorithm | ||||
Initial dose | 10 units/day | 10 units/day | Not specified | 10 units/day |
Titration | 2 units every 3 days | 1–3 units every 2–3 days | 2 units every 3 days | 1 unit daily |
Target A1C (%) | <7.0 | ≤6.5 | ≤6.5 | ≤7.0 |
Target FPG (mg/dL) | 70–130 | <110* | <110 | 72–126 |
Prandial algorithm | ||||
Initial dose | 4 units | 5 units | Not specified | Total daily dose of 0.3–0.5 units/kg† 40% of total = basal 20% of total = bolus (3 times/day) |
Titration | 2 units every 3 days | 2–3 units every 2–3 days | 2 units every 3 days | Not available |
Target A1C (%) | <7.0 | ≤6.5 | ≤6.5 | ≤7.0 |
Target PPG (mg/dL) | <180 | ≤140‡ | <145 | 90–180§ |
Measure | ADA/EASD | AACE/ACE | IDF | CDA |
Basal algorithm | ||||
Initial dose | 10 units/day | 10 units/day | Not specified | 10 units/day |
Titration | 2 units every 3 days | 1–3 units every 2–3 days | 2 units every 3 days | 1 unit daily |
Target A1C (%) | <7.0 | ≤6.5 | ≤6.5 | ≤7.0 |
Target FPG (mg/dL) | 70–130 | <110* | <110 | 72–126 |
Prandial algorithm | ||||
Initial dose | 4 units | 5 units | Not specified | Total daily dose of 0.3–0.5 units/kg† 40% of total = basal 20% of total = bolus (3 times/day) |
Titration | 2 units every 3 days | 2–3 units every 2–3 days | 2 units every 3 days | Not available |
Target A1C (%) | <7.0 | ≤6.5 | ≤6.5 | ≤7.0 |
Target PPG (mg/dL) | <180 | ≤140‡ | <145 | 90–180§ |
FPG target recommendations from the AACE 2011 guidelines
For initiation of intensive basal bolus therapy.
PPG target recommendations from AACE 2011 guidelines
Adjust to 90–144 mg/dL if A1C targets are not being met.
AACE, American Association of Clinical Endocrinologists; ACE, American College of Endocrinology; ADA, American Diabetes Association; CDA, Canadian Diabetes Association; EASD, European Association for the Study of Diabetes; FPG, fasting plasma glucose; IDF, International Diabetes Federation; PPG, postprandial glucose.