Diabetes and Influenza
This special series of Diabetes Core Update is supported by an independent educational grant from Sanofi.
The Centers for Disease Control and Prevention estimates that influenza has resulted in 9–45 million illnesses, 140,000–810,000 hospitalizations, and 12,000–61,000 deaths each year in the U.S since 2010. Influenza is associated with a higher prevalence of mortality, morbidity, and adverse events in vulnerable populations, including people with diabetes. And even though influenza vaccination in people with diabetes has been found to significantly reduce influenza and diabetes-related hospital admissions, only 60–65% of adults with diabetes receive a vaccination each year.
In this special three-episode series made possible by an unrestricted educational grant from Sanofi Pasteur, Diabetes Core Update will explore the complicated relationship between diabetes and influenza. In each episode, Drs. Neil Skolnik and John Russell of Abington Memorial Hospital and the Temple University School of Medicine will present and discuss the latest clinically relevant articles and information related to the impact of diabetes on influenza-related mortality rates, influenza-related complications in persons with diabetes, and the important role clinicians can play in encouraging patients with diabetes to get their annual influenza vaccination.
DIABETES AND INFLUENZA
Post Date: December 17, 2020
In the third episode of this special three-part series, Drs. Skolnik and Russell address frequently asked questions related influenza, influenza vaccines, how influenza affects people with diabetes, and how health care providers can encourage their patients to get an influenza vaccination. In the course of their discussion, Drs. Skolnik and Russell refer to the following studies:
MacIntyre CR, Mahimbo A, Moa AM, Barnes M. Influenza vaccine as a coronary intervention for prevention of myocardial infarction. Heart. 2016 Dec 15;102(24):1953-1956. doi:10.1136/heartjnl-2016-309983. Epub 2016 Sep 29. PMID: 27686519.
Warren-Gash C, Blackburn R, Whitaker H, et al. Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland. Eur Respir J. 2018 Mar 29;51(3):1701794. doi:10.1183/13993003.01794-2017. PMID: 29563170; PMCID: PMC5898931.
Dunkle LM, Izikson R, Patriarca P, et al., for the PSC12 Study Team. Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older. N Engl J Med. 2017 Jun 22;376(25):2427-2436. doi:10.1056/NEJMoa1608862. PMID: 28636855.
DiazGranados CA, Dunning AJ, Kimmel M, et al. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med. 2014 Aug 14;371(7):635-45. doi:10.1056/NEJMoa1315727. PMID: 25119609.
Izurieta HS, Thadani N, Shay DK, et al. Comparative effectiveness of high-dose versus standard-dose influenza vaccines in US residents aged 65 years and older from 2012 to 2013 using Medicare data: a retrospective cohort analysis. Lancet Infect Dis. 2015 Mar;15(3):293-300. doi:10.1016/S1473-3099(14)71087-4. PMID: 25672568.
This episode concludes this special three-part series on influenza and diabetes. Diabetes Core Update and the American Diabetes Association thank Sanofi Pasteur, the vaccines global business unit of Sanofi, which supported this series through an unrestricted educational grant.
Post Date: September 29, 2020
In the second episode of this special three-part series, Drs. Skolnik and Russell discuss the impact of influenza on people with diabetes and, thus, the importance of getting an influenza vaccination for people with diabetes.
Looijmans-Van den Akker I, Verheij TJ, Buskens E, Nichol KL, Rutten GE, Hak E. Clinical effectiveness of first and repeat influenza vaccination in adult and elderly diabetic patients. Diabetes Care. 2006 Aug;29(8):1771-6. doi: 10.2337/dc05-2517. PMID: 16873778
Vamos EP, Pape UJ, Curcin V, Harris MJ, Valabhji J, Majeed A, Millett C. Effectiveness of the influenza vaccine in preventing admission to hospital and death in people with type 2 diabetes. CMAJ. 2016 Oct 4;188(14):E342-E351. doi: 10.1503/cmaj.151059. Epub 2016 Jul 25. PMID: 27455981; PMCID: PMC5047834.
Modin D, Claggett B, Køber L, Schou M, Jensen JUS, Solomon SD, Vardeny O, Knop FK, Nielsen SD, Fralick M, Torp-Pedersen C, Gislason G, Biering-Sørensen T. Influenza Vaccination Is Associated With Reduced Cardiovascular Mortality in Adults With Diabetes: A Nationwide Cohort Study. Diabetes Care. 2020 Sep;43(9):2226-2233. doi: 10.2337/dc20-0229. PMID: 32647052.
Barnes M, Heywood AE, Mahimbo A, Rahman B, Newall AT, Macintyre CR. Acute myocardial infarction and influenza: a meta-analysis of case-control studies. Heart. 2015 Nov;101(21):1738-47. doi: 10.1136/heartjnl-2015-307691. Epub 2015 Aug 26. PMID: 26310262; PMCID: PMC4680124.
DiazGranados CA, Dunning AJ, Kimmel M, Kirby D, Treanor J, Collins A, Pollak R, Christoff J, Earl J, Landolfi V, Martin E, Gurunathan S, Nathan R, Greenberg DP, Tornieporth NG, Decker MD, Talbot HK. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med. 2014 Aug 14;371(7):635-45. doi: 10.1056/NEJMoa1315727. PMID: 25119609.
In episode 3, Drs. Skolnik and Russell will discuss the important role that clinicians play in improving vaccination rates among patients with diabetes. This special three-part series on influenza and diabetes is supported by an unrestricted educational grant from Sanofi Pasteur, the vaccines global business unit of Sanofi.
Post Date: June 23, 2020
In the first episode of this special three-part series, Drs. Skolnik and Russell discuss the impact of diabetes on influenza-related morbidity, mortality, and adverse events.
Beumer MC, Koch RM, van Beuningen D, OudeLashof AM, van de Veerdonk FL, Kolwijck E, van der Hoeven JG, Bergmans DC, Hoedemaekers CWE. Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality. J Crit Care. 2019 Apr;50:59-65. doi: 10.1016/j.jcrc.2018.11.013. Epub 2018 Nov 15. PMID: 30481669; PMCID: PMC7125534.
Valdez R, Narayan KM, Geiss LS, Engelgau MM. Impact of diabetes mellitus on mortality associated with pneumonia and influenza among non-Hispanic black and white US adults. Am J Public Health. 1999 Nov;89(11):1715-21. doi: 10.2105/ajph.89.11.1715. PMID: 10553394; PMCID: PMC1508989.
Li S, Wang J, Zhang B, Li X, Liu Y. Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study. Diabetes Metab J. 2019 Jun;43(3):319-341. doi: 10.4093/dmj.2018.0060. PMID: 31210036; PMCID: PMC6581547.
In episodes 2 and 3, Drs. Skolnik and Russell will take a closer look into the influenza-related complications in persons with diabetes and will discuss the important role that clinicians play in improving vaccination rates among patients with diabetes. This special three-part series on influenza and diabetes is supported by an unrestricted educational grant from Sanofi Pasteur, the vaccines global business unit of Sanofi.
REFERENCES AND RELATED RESOURCES
Diabetes Core Update is a monthly audio podcast devoted to presenting and discussing the latest clinically relevant articles from ADA’s four scholarly journals: Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Users can freely access previous episodes of Diabetes Core Update here.