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Meeting Abstracts

295-OR: Mechanisms of Antigen-Specific Immunotherapy following Tolerance Induction to a CD4 Hybrid Insulin Peptide Epitope and the Impact on CD8 T Cell Dysfunction

JAMES E. DILISIO, ROCKY L. BAKER, KATHRYN M. HASKINS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):295-OR
https://doi.org/10.2337/db23-295-OR
Published: 20 June 2023
View article titled, 295-OR: Mechanisms of Antigen-Specific Immunotherapy following Tolerance Induction to a CD4 Hybrid Insulin Peptide Epitope and the Impact on CD8 T Cell Dysfunction
Meeting Abstracts

229-LB: Generation of Human CAR-Treg Cells for Inducing Immunological Tolerance against Diabetogenic T Cells in Human Pancreatic Islets

SHAHNAWAZ IMAM, SHAFIYA IMTIAZ RAFIQI, JUAN C. JAUME
Journal: Diabetes
Diabetes 2023;72(Supplement_1):229-LB
https://doi.org/10.2337/db23-229-LB
Published: 20 June 2023
View article titled, 229-LB: Generation of Human CAR-Treg Cells for Inducing Immunological Tolerance against Diabetogenic T Cells in Human Pancreatic Islets
Meeting Abstracts

1488-P: Reduced iPLA2b Expression in T-Lymphocytes Decreases Proinflammatory Eicosanoid Production and Cytokine Secretion Delaying Type 1 Diabetes Development in NOD Mice

TAYLEUR WHITE, SASANKA RAMANADHAM, TERESA P. DILORENZO, CHARLES E. CHALFANT
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1488-P
https://doi.org/10.2337/db23-1488-P
Published: 20 June 2023
View article titled, 1488-P: Reduced iPLA2b Expression in T-Lymphocytes Decreases Proinflammatory Eicosanoid Production and Cytokine Secretion Delaying Type 1 Diabetes Development in NOD Mice
Journal Articles

Protective Renalase Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes

Kevin Bode, Tara MacDonald, Taylor Stewart, Bryhan Mendez, Erica P. Cai, Noelle Morrow, Yu-Chi Lee, Peng Yi, Stephan Kissler
Journal: Diabetes
Diabetes 2023;72(8):1127–1143
https://doi.org/10.2337/db23-0030
Published: 22 May 2023
View article titled, Protective <em>Renalase</em> Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes
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Journal Articles

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Journal: Diabetes
Diabetes 2023;72(2):261–274
https://doi.org/10.2337/db22-0521
Published: 08 November 2022
View article titled, An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
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Journal Articles

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes

Perrin Guyer, David Arribas-Layton, Anthony Manganaro, Cate Speake, Sandra Lord, Decio L. Eizirik, Sally C. Kent, Roberto Mallone, Eddie A. James
Journal: Diabetes
Diabetes 2023;72(1):85–96
https://doi.org/10.2337/db22-0191
Published: 06 October 2022
View article titled, Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4<sup>+</sup> T Cells in Type 1 Diabetes
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Journal Articles

Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes

Samantha A. Crawford, Timothy A. Wiles, Janet M. Wenzlau, Roger L. Powell, Gene Barbour, Mylinh Dang, Jason Groegler, Jessie M. Barra, KaLia S. Burnette, Anita C. Hohenstein, Rocky L. Baker, Hubert M. Tse, Kathryn Haskins, Thomas Delong
Journal: Diabetes
Diabetes 2022;71(12):2793–2803
https://doi.org/10.2337/db22-0303
Published: 30 August 2022
View article titled, Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes
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Journal Articles

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini
Journal: Diabetes
Diabetes 2022;71(8):1735–1745
https://doi.org/10.2337/db21-1069
Published: 21 August 2022
View article titled, Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes
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Journal Articles

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Roberto Mallone, Clémentine Halliez, Jinxiu Rui, Kevan C. Herold
Journal: Diabetes
Diabetes 2022;71(8):1603–1610
https://doi.org/10.2337/dbi21-0036
Published: 21 August 2022
View article titled, The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?
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Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Journal: Diabetes
Diabetes 2022;71(9):1979–1993
https://doi.org/10.2337/db21-0989
Published: 22 June 2022
View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
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Journal Articles

Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells

Sherman S. Leung, Danielle J. Borg, Domenica A. McCarthy, Tamar E. Boursalian, Justen Cracraft, Aowen Zhuang, Amelia K. Fotheringham, Nicole Flemming, Thomas Watkins, John J. Miles, Per-Henrik Groop, Jean L. Scheijen, Casper G. Schalkwijk, Raymond J. Steptoe, Kristen J. Radford, Mikael Knip, Josephine M. Forbes
Journal: Diabetes
Diabetes 2022;71(9):1994–2008
https://doi.org/10.2337/db22-0177
Published: 17 June 2022
View article titled, Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells
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Meeting Abstracts

183-OR: Overcoming Immunological Barriers for “Off-the-Shelf” iPSC-Derived Islets

XIAOMENG HU, KATHY WHITE, ARI G. OLROYD, ROWENA DEJESUS, ANTONIA DOMINGUEZ, WILLIAM E. DOWDLE, ELAINE Y.L. CHU, ANNABELLE FRIERA, CHI YOUNG, FRANK WELLS, TREVOR MCGILL, MICHAEL RUKSTALIS, CORIE GATTIS, RONALD BASCO, JEFFREY R. MILLMAN, SONJA SCHREPFER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):183-OR
https://doi.org/10.2337/db22-183-OR
Published: 01 June 2022
View article titled, 183-OR: Overcoming Immunological Barriers for “Off-the-Shelf” iPSC-Derived Islets
Meeting Abstracts

193-LB: Differentiation of PTPN2 Knockout Pluripotent Stem Cells into Stem-Cell–Derived ß-Like Cells Leads to Increased Stimulation of Diabetogenic TCR T Cell Transductants

JULIA Q. MATUSCHEK, HOLGER A. RUSS, TAYLOR M. TRIOLO, AARON W. MICHELS, KRISTEN MCDANIEL, MARIA S. HANSEN, SHANE WILLIAMS, ROBERTO CASTRO-GUTIERREZ, ALI SHILLEH
Journal: Diabetes
Diabetes 2022;71(Supplement_1):193-LB
https://doi.org/10.2337/db22-193-LB
Published: 01 June 2022
View article titled, 193-LB: Differentiation of PTPN2 Knockout Pluripotent Stem Cells into Stem-Cell–Derived ß-Like Cells Leads to Increased Stimulation of Diabetogenic TCR T Cell Transductants
Meeting Abstracts

74-OR: Adoptively Transferred T Lymphocytes with Reduced iPLA2b Expression Delays Type 1 Diabetes Development in NOD Mice

TAYLEUR WHITE, CHARLES CHALFANT, TERESA P. DILORENZO, SASANKA RAMANADHAM, DANIEL STEPHENSON
Journal: Diabetes
Diabetes 2022;71(Supplement_1):74-OR
https://doi.org/10.2337/db22-74-OR
Published: 01 June 2022
View article titled, 74-OR: Adoptively Transferred T Lymphocytes with Reduced iPLA2b Expression Delays Type 1 Diabetes Development in NOD Mice
Meeting Abstracts

73-OR: Loss of NADPH Oxidase–Derived Superoxide Impairs Autoreactive T Cell Trafficking into Islets to Delay Type 1 Diabetes Development

SAMUEL I. BLUM, JESSIE BARRA, ROCKY L. BAKER, HUBERT M. TSE
Journal: Diabetes
Diabetes 2022;71(Supplement_1):73-OR
https://doi.org/10.2337/db22-73-OR
Published: 01 June 2022
View article titled, 73-OR: Loss of NADPH Oxidase–Derived Superoxide Impairs Autoreactive T Cell Trafficking into Islets to Delay Type 1 Diabetes Development
Journal Articles

T-Cell Autoreactivity in Type 2 Diabetes: Benign or Pathogenic, Smoke or Fire?

Angus G. Jones, Martin Eichmann
Journal: Diabetes
Diabetes 2022;71(6):1167–1169
https://doi.org/10.2337/dbi22-0007
Published: 20 May 2022
View article titled, T-Cell Autoreactivity in Type 2 Diabetes: Benign or Pathogenic, Smoke or Fire?
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Journal Articles

p38α Deficiency in T Cells Ameliorates Diet-Induced Obesity, Insulin Resistance, and Adipose Tissue Senescence

Deyun Meng, Baohua Zhang, Yanyan Wang, Tingting Zheng, Ran Hu, Bin Wang, Kinya Otsu, Ying Wang, Gonghua Huang
Journal: Diabetes
Diabetes 2022;71(6):1205–1217
https://doi.org/10.2337/db21-0653
Published: 29 March 2022
View article titled, p38α Deficiency in T Cells Ameliorates Diet-Induced Obesity, Insulin Resistance, and Adipose Tissue Senescence
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Journal Articles

T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

Yi Jing, Yuelin Kong, John McGinty, Gabriele Blahnik-Fagan, Thomas Lee, Stephanie Orozco-Figueroa, Matthew L. Bettini, Eddie A. James, Maria Bettini
Journal: Diabetes
Diabetes 2022;71(5):1012–1022
https://doi.org/10.2337/db21-0993
Published: 18 February 2022
View article titled, T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope
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Journal Articles

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Yuk-Fun Liu, Jake Powrie, Sefina Arif, Jennie H.M. Yang, Evangelia Williams, Leena Khatri, Mamta Joshi, Loic Lhuillier, Nikolaos Fountoulakis, Emma Smith, Craig Beam, Anna Lorenc, Mark Peakman, Timothy Tree
Journal: Diabetes
Diabetes 2022;71(4):722–732
https://doi.org/10.2337/db21-0728
Published: 24 January 2022
View article titled, Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
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Journal Articles

Islet Autoimmunity Is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the GRADE Study

Barbara Brooks-Worrell, Christiane S. Hampe, Erica G. Hattery, Brenda Palomino, Sahar Z. Zangeneh, Kristina Utzschneider, Steven E. Kahn, Mary E. Larkin, Mary L. Johnson, Kieren J. Mather, Naji Younes, Neda Rasouli, Cyrus Desouza, Robert M. Cohen, Jean Y. Park, Hermes J. Florez, Willy Marcos Valencia, GRADE β-cell Ancillary Study Network, Ali Shojaie, Jerry P. Palmer, Ashok Balasubramanyam
Journal: Diabetes
Diabetes 2022;71(6):1261–1271
https://doi.org/10.2337/db21-0590
Published: 21 January 2022
View article titled, Islet Autoimmunity Is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the GRADE Study
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