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Meeting Abstracts

836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial

TREVOR W. REICHMAN, CAMILLO RICORDI, ALI NAJI, JAMES F. MARKMANN, BRUCE A. PERKINS, MARTIN WIJKSTROM, STEVEN PARASKEVAS, BOTE BRUINSMA, GAUTHAM MARIGOWDA, JUDY L. SHIH, CHENKUN WANG, DOUGLAS MELTON, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):836-P
https://doi.org/10.2337/db23-836-P
Published: 23 June 2023
View article titled, 836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial
Meeting Abstracts

86-OR: Self-Organized Insulin-Producing ß-Cells Differentiated from Human Omentum-Derived Stem Cells

YONGSUNG HWANG
Journal: Diabetes
Diabetes 2023;72(Supplement_1):86-OR
https://doi.org/10.2337/db23-86-OR
Published: 20 June 2023
View article titled, 86-OR: Self-Organized Insulin-Producing ß-Cells Differentiated from Human Omentum-Derived Stem Cells
Meeting Abstracts

289-LB: Intestinal Stem Cells as a Source of Insulin-Positive Beta-Like Cells for Treating Diabetes

YU XIAO, YAO XIAO, YINAN JIANG
Journal: Diabetes
Diabetes 2023;72(Supplement_1):289-LB
https://doi.org/10.2337/db23-289-LB
Published: 20 June 2023
View article titled, 289-LB: Intestinal Stem Cells as a Source of Insulin-Positive Beta-Like Cells for Treating Diabetes
Meeting Abstracts

269-LB: Modeling Alpha-Cell Dysfunction Using Stem Cell–Derived Alpha Cells

SWIKRITI SHRESTHA, QUINN P. PETERSON
Journal: Diabetes
Diabetes 2023;72(Supplement_1):269-LB
https://doi.org/10.2337/db23-269-LB
Published: 20 June 2023
View article titled, 269-LB: Modeling Alpha-Cell Dysfunction Using Stem Cell–Derived Alpha Cells
Journal Articles

Erratum. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes. Diabetes 2021;70:2419–2429

Diane Yang, Sanjeet Patel, Wojciech J. Szlachcic, Jolanta Chmielowiec, Diane Scaduto, Nagireddy Putluri, Arun Sreekumar, James Suliburk, Michael Metzker, Ashok Balasubramanyam, Malgorzata Borowiak
Journal: Diabetes
Diabetes 2023;72(6):821
https://doi.org/10.2337/db23-er06b
Published: 17 April 2023
View article titled, Erratum. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes. Diabetes 2021;70:2419–2429
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Journal Articles

Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose Cells

Birgit Gustafson, Annika Nerstedt, Rosa Spinelli, Francesco Beguinot, Ulf Smith
Journal: Diabetes
Diabetes 2022;71(11):2372–2383
https://doi.org/10.2337/db22-0003
Published: 25 August 2022
View article titled, Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose Cells
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Journal Articles

miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo

Wenyi Luo, Youngsil Kim, Mary Ellen Jensen, Oana Herlea-Pana, Weidong Wang, Michael C. Rudolph, Jacob E. Friedman, Steven D. Chernausek, Shaoning Jiang
Journal: Diabetes
Diabetes 2022;71(11):2360–2371
https://doi.org/10.2337/db22-0205
Published: 24 August 2022
View article titled, miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo
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Meeting Abstracts

193-LB: Differentiation of PTPN2 Knockout Pluripotent Stem Cells into Stem-Cell–Derived ß-Like Cells Leads to Increased Stimulation of Diabetogenic TCR T Cell Transductants

JULIA Q. MATUSCHEK, HOLGER A. RUSS, TAYLOR M. TRIOLO, AARON W. MICHELS, KRISTEN MCDANIEL, MARIA S. HANSEN, SHANE WILLIAMS, ROBERTO CASTRO-GUTIERREZ, ALI SHILLEH
Journal: Diabetes
Diabetes 2022;71(Supplement_1):193-LB
https://doi.org/10.2337/db22-193-LB
Published: 01 June 2022
View article titled, 193-LB: Differentiation of PTPN2 Knockout Pluripotent Stem Cells into Stem-Cell–Derived ß-Like Cells Leads to Increased Stimulation of Diabetogenic TCR T Cell Transductants
Meeting Abstracts

259-OR: Stem Cell–Derived, Fully Differentiated Islet Cells for Type 1 Diabetes

JAMES F. MARKMANN, ALI NAJI, MICHAEL R. RICKELS, MARIA ALBA, GAUTHAM MARIGOWDA, LEORAH ROSS, CHENKUN WANG, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, CAMILLO RICORDI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):259-OR
https://doi.org/10.2337/db22-259-OR
Published: 01 June 2022
View article titled, 259-OR: Stem Cell–Derived, Fully Differentiated Islet Cells for Type 1 Diabetes
Meeting Abstracts

1295-P: Learning from Immune Privileged Tissue Stem Cells to Generate Hypoimmunogenic Islets

JUDITH AGUDO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1295-P
https://doi.org/10.2337/db22-1295-P
Published: 01 June 2022
View article titled, 1295-P: Learning from Immune Privileged Tissue Stem Cells to Generate Hypoimmunogenic Islets
Meeting Abstracts

305-OR: Quiescence Abrogates Stress-Induced Senescence-Associated Secretion Phenotype in Adipose-Derived Stem Cells and May Enhance Their Therapeutic Effects on Diabetic Complications

MAKOTO FUNAKI, AKIKO HATA, MITSUTERU YOSHIDA, NAOKI MIYAMOTO, TAKAHISA IKUTA, YUTA UEMURA, MINATO AKIZUKI, AKIRA TANGOKU, HIROMICHI YUMOTO, HIROHISA OGAWA, TAKESHI OYA
Journal: Diabetes
Diabetes 2022;71(Supplement_1):305-OR
https://doi.org/10.2337/db22-305-OR
Published: 01 June 2022
View article titled, 305-OR: Quiescence Abrogates Stress-Induced Senescence-Associated Secretion Phenotype in Adipose-Derived Stem Cells and May Enhance Their Therapeutic Effects on Diabetic Complications
Journal Articles

Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells

Yao Xie, Yongli Ji, Yunrui Lu, Yuankun Ma, Hui Ni, Jian Shen, Hong Ma, Chunna Jin, Yuwen Chen, Yan Lin, Meixiang Xiang
Journal: Diabetes
Diabetes 2022;71(2):321–328
https://doi.org/10.2337/db20-1129
Published: 09 November 2021
View article titled, Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells
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Journal Articles

Heal Thyself: SGLT2 Inhibition Limits Regenerative Cell Exhaustion and Heals Damaged Vessels

David A. Hess, Daniella C. Terenzi, Subodh Verma
Journal: Diabetes
Diabetes 2021;70(8):1620–1622
https://doi.org/10.2337/dbi21-0025
Published: 13 August 2021
View article titled, Heal Thyself: SGLT2 Inhibition Limits Regenerative Cell Exhaustion and Heals Damaged Vessels
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Journal Articles

ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro

Fiona M. Docherty, Kent A. Riemondy, Roberto Castro-Gutierrez, JaeAnn M. Dwulet, Ali H. Shilleh, Maria S. Hansen, Shane P.M. Williams, Lucas H. Armitage, Katherine E. Santostefano, Mark A. Wallet, Clayton E. Mathews, Taylor M. Triolo, Richard K.P. Benninger, Holger A. Russ
Journal: Diabetes
Diabetes 2021;70(11):2554–2567
https://doi.org/10.2337/db20-0873
Published: 11 August 2021
View article titled, ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro
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Journal Articles

Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes

Diane Yang, Sanjeet Patel, Wojciech J. Szlachcic, Jolanta Chmielowiec, Diane Scaduto, Nagireddy Putluri, Arun Sreekumar, James Suliburk, Michael Metzker, Ashok Balasubramanyam, Malgorzata Borowiak
Journal: Diabetes
Diabetes 2021;70(10):2419–2429
https://doi.org/10.2337/db20-1293
Published: 03 August 2021
View article titled, Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes
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Meeting Abstracts

1242-P: Defining the Nkx6.1 Interactome in Beta Cells Reveals a Novel Interaction with Pdx1

CONNOR C. LITTLEFIELD, NATHANAEL C. JENSEN, JONATHON T. HILL, JOHN C. PRICE, JEFFERY S. TESSEM
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1242-P
https://doi.org/10.2337/db21-1242-P
Published: 01 June 2021
View article titled, 1242-P: Defining the Nkx6.1 Interactome in Beta Cells Reveals a Novel Interaction with Pdx1
Meeting Abstracts

196-LB: Stem Cell–Derived Islet Replacement Therapy (VC-02) Demonstrates Production of C-Peptide in Patients with Type 1 Diabetes (T1D) and Hypoglycemia Unawareness

BART KEYMEULEN, DANIEL JACOBS-TULLENEERS-THEVISSEN, SR., EVERT J. KROON, MANASI S. JAIMAN, MARK DANIELS, RICHARD WANG, DANIEL PIPELEERS, KEVIN D’AMOUR, HOWARD L. FOYT
Journal: Diabetes
Diabetes 2021;70(Supplement_1):196-LB
https://doi.org/10.2337/db21-196-LB
Published: 01 June 2021
View article titled, 196-LB: Stem Cell–Derived Islet Replacement Therapy (VC-02) Demonstrates Production of C-Peptide in Patients with Type 1 Diabetes (T1D) and Hypoglycemia Unawareness
Meeting Abstracts

177-OR: The Swi/Snf Chromatin Remodeling Complex Controls the Specification, Expansion, and Differentiation of Pancreatic Endocrine Progenitor Cells

JASON SPAETH, REBECCA K. DAVIDSON, NOLAN CASEY
Journal: Diabetes
Diabetes 2021;70(Supplement_1):177-OR
https://doi.org/10.2337/db21-177-OR
Published: 01 June 2021
View article titled, 177-OR: The Swi/Snf Chromatin Remodeling Complex Controls the Specification, Expansion, and Differentiation of Pancreatic Endocrine Progenitor Cells
Journal Articles

Deciphering the Complex Communication Networks That Orchestrate Pancreatic Islet Function

Jonathan Weitz, Danusa Menegaz, Alejandro Caicedo
Journal: Diabetes
Diabetes 2021;70(1):17–26
https://doi.org/10.2337/dbi19-0033
Published: 15 December 2020
View article titled, Deciphering the Complex Communication Networks That Orchestrate Pancreatic Islet Function
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Meeting Abstracts

1682-P: Cotransplantation of Islets with Adipose-Derived Stem Cells Synergistically Reduced Blood Glucose in STZ-Induced Diabetic Rats

XIAO-DONG CHEN, SHENGXIAN LI, HANZHOU WANG
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1682-P
https://doi.org/10.2337/db20-1682-P
Published: 01 June 2020
View article titled, 1682-P: Cotransplantation of Islets with Adipose-Derived Stem Cells Synergistically Reduced Blood Glucose in STZ-Induced Diabetic Rats